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Retrospective comparison of flot and modified dcf as first-line chemotherapy in metastatic gastric adenocarcinoma
BACKGROUND/AIM: The aim of our study was to compare the efficacy and the safety of the FLOT and the modified DCF (mDCF) regimens in patients with metastatic gastric (GC) and gastroesophageal junction (GEJ) adenocarcinoma as first-line treatment. MATERIALS AND METHODS: The medical records of 72 patie...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Scientific and Technological Research Council of Turkey (TUBITAK)
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395706/ https://www.ncbi.nlm.nih.gov/pubmed/36422493 http://dx.doi.org/10.55730/1300-0144.5496 |
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author | GÜRLER, Fatih GÜVEN, Deniz Can AYDEMİR, Ergin SÜTÇÜOĞLU, Osman KURT İNCİ, Bediz ARIK, Zafer YALÇIN, Şuayib ÖZDEMİR, Nuriye ÖZET, Ahmet YAZICI, Ozan |
author_facet | GÜRLER, Fatih GÜVEN, Deniz Can AYDEMİR, Ergin SÜTÇÜOĞLU, Osman KURT İNCİ, Bediz ARIK, Zafer YALÇIN, Şuayib ÖZDEMİR, Nuriye ÖZET, Ahmet YAZICI, Ozan |
author_sort | GÜRLER, Fatih |
collection | PubMed |
description | BACKGROUND/AIM: The aim of our study was to compare the efficacy and the safety of the FLOT and the modified DCF (mDCF) regimens in patients with metastatic gastric (GC) and gastroesophageal junction (GEJ) adenocarcinoma as first-line treatment. MATERIALS AND METHODS: The medical records of 72 patients were retrospectively reviewed. Survivals and hematological adverse events of the patients were examined. Factors affecting survivals were analyzed in univariate analysis. A multivariate analysis was performed with the factors contributing to survivals in univariate analysis. RESULTS: The median PFS (mPFS) was 10.1 months (95% CI, 6.8–13.4) in the FLOT arm (n = 33) and 7.4 months (95% CI, 9.1–21.6) in the mDCF arm (n = 39) (p = 0.041). The median OS (mOS) was 12.9 months (95% CI, 9.7–16.1) in the FLOT arm and 15.4 months (95% CI, 9.1–21.6) in the mDCF arm (p = 0.622). It was found that all grade neutropenia was 51.3% vs. 72.7% (p = 0.063), febrile neutropenia was 8.3% vs. 6.3% (p = 0.743), and thrombocytopenia was 48.7% vs. 51.5% (p = 0.813) in the FLOT and mDCF arms, respectively. Anemia was 59% in the FLOT arm and 100% in the mDCF arm (p < 0.001). Grade 3–4 anemia was 7.7% in the FLOT arm and 24.2% in the mDCF arm (p = 0.052). CONCLUSION: It was shown that the mPFS was significantly increased in the FLOT arm compared to the mDCF arm as the first-line treatment in patients with metastatic GC and GEJC. Hematological adverse events were more favorable in the FLOT arm than in the mDCF arm. |
format | Online Article Text |
id | pubmed-10395706 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Scientific and Technological Research Council of Turkey (TUBITAK) |
record_format | MEDLINE/PubMed |
spelling | pubmed-103957062023-08-03 Retrospective comparison of flot and modified dcf as first-line chemotherapy in metastatic gastric adenocarcinoma GÜRLER, Fatih GÜVEN, Deniz Can AYDEMİR, Ergin SÜTÇÜOĞLU, Osman KURT İNCİ, Bediz ARIK, Zafer YALÇIN, Şuayib ÖZDEMİR, Nuriye ÖZET, Ahmet YAZICI, Ozan Turk J Med Sci Research Article BACKGROUND/AIM: The aim of our study was to compare the efficacy and the safety of the FLOT and the modified DCF (mDCF) regimens in patients with metastatic gastric (GC) and gastroesophageal junction (GEJ) adenocarcinoma as first-line treatment. MATERIALS AND METHODS: The medical records of 72 patients were retrospectively reviewed. Survivals and hematological adverse events of the patients were examined. Factors affecting survivals were analyzed in univariate analysis. A multivariate analysis was performed with the factors contributing to survivals in univariate analysis. RESULTS: The median PFS (mPFS) was 10.1 months (95% CI, 6.8–13.4) in the FLOT arm (n = 33) and 7.4 months (95% CI, 9.1–21.6) in the mDCF arm (n = 39) (p = 0.041). The median OS (mOS) was 12.9 months (95% CI, 9.7–16.1) in the FLOT arm and 15.4 months (95% CI, 9.1–21.6) in the mDCF arm (p = 0.622). It was found that all grade neutropenia was 51.3% vs. 72.7% (p = 0.063), febrile neutropenia was 8.3% vs. 6.3% (p = 0.743), and thrombocytopenia was 48.7% vs. 51.5% (p = 0.813) in the FLOT and mDCF arms, respectively. Anemia was 59% in the FLOT arm and 100% in the mDCF arm (p < 0.001). Grade 3–4 anemia was 7.7% in the FLOT arm and 24.2% in the mDCF arm (p = 0.052). CONCLUSION: It was shown that the mPFS was significantly increased in the FLOT arm compared to the mDCF arm as the first-line treatment in patients with metastatic GC and GEJC. Hematological adverse events were more favorable in the FLOT arm than in the mDCF arm. Scientific and Technological Research Council of Turkey (TUBITAK) 2022-07-28 /pmc/articles/PMC10395706/ /pubmed/36422493 http://dx.doi.org/10.55730/1300-0144.5496 Text en © TÜBİTAK https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License. |
spellingShingle | Research Article GÜRLER, Fatih GÜVEN, Deniz Can AYDEMİR, Ergin SÜTÇÜOĞLU, Osman KURT İNCİ, Bediz ARIK, Zafer YALÇIN, Şuayib ÖZDEMİR, Nuriye ÖZET, Ahmet YAZICI, Ozan Retrospective comparison of flot and modified dcf as first-line chemotherapy in metastatic gastric adenocarcinoma |
title | Retrospective comparison of flot and modified dcf as first-line chemotherapy in metastatic gastric adenocarcinoma |
title_full | Retrospective comparison of flot and modified dcf as first-line chemotherapy in metastatic gastric adenocarcinoma |
title_fullStr | Retrospective comparison of flot and modified dcf as first-line chemotherapy in metastatic gastric adenocarcinoma |
title_full_unstemmed | Retrospective comparison of flot and modified dcf as first-line chemotherapy in metastatic gastric adenocarcinoma |
title_short | Retrospective comparison of flot and modified dcf as first-line chemotherapy in metastatic gastric adenocarcinoma |
title_sort | retrospective comparison of flot and modified dcf as first-line chemotherapy in metastatic gastric adenocarcinoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395706/ https://www.ncbi.nlm.nih.gov/pubmed/36422493 http://dx.doi.org/10.55730/1300-0144.5496 |
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