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Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients

BACKGROUND/AIM: This study aims to investigate the diagnostic utility of new erythrocytes, leukocytes, and reticulocytes parameters for the identification of subclinical iron deficiency (ID) in children under 6 years with nonsevere acute infection in pediatric outpatients. MATERIALS AND METHODS: The...

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Autores principales: KARAKAŞ, Nazmi Mutlu, KİRKİZ, Serap, KAYA, Zühre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Scientific and Technological Research Council of Turkey (TUBITAK) 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395708/
https://www.ncbi.nlm.nih.gov/pubmed/36422508
http://dx.doi.org/10.55730/1300-0144.5509
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author KARAKAŞ, Nazmi Mutlu
KİRKİZ, Serap
KAYA, Zühre
author_facet KARAKAŞ, Nazmi Mutlu
KİRKİZ, Serap
KAYA, Zühre
author_sort KARAKAŞ, Nazmi Mutlu
collection PubMed
description BACKGROUND/AIM: This study aims to investigate the diagnostic utility of new erythrocytes, leukocytes, and reticulocytes parameters for the identification of subclinical iron deficiency (ID) in children under 6 years with nonsevere acute infection in pediatric outpatients. MATERIALS AND METHODS: The study included 102 children with acute infections and 31 true ID. Traditional and new hematology parameters were measured in a Sysmex-XN(®), along with C-reactive protein level, and iron parameters. Participants’ ID were categorized as: the ferritin < 100 ng/mL, transferrin saturation < 20% was defined as “subclinical or functional ID (FID) in Group 1”; ferritin < 30 ng/mL, transferrin saturation < 20%, as “absolute-ID (AID)” in Group 2; ferritin < 12 ng/mL without anemia and infection, as “true ID” in Group 3. RESULTS: The frequencies of FID and AID among the 102 children with acute infection were 24% and 76%, respectively. Compared with the Group 2 patients, Group 1 had a significantly higher mean percentage of hypochromic erythrocytes (Hypo-He), and significantly lower levels of hemoglobin (Hb) and Hb content of reticulocytes (RET-He) (p < 0.05 for all). Compared with Group 2 and Group 3 patients, Group 1 had a significantly higher mean percentage of immature reticulocyte fraction (IRF) and immature granulocyte (IG) values (p < 0.05 for all). The RET-He, IRF%, Hypo-He%, and IG% cut-off values for predicting FID during infection were 27.0 pg, 10.6%, 2.5%, and 0.35% respectively. CONCLUSION: The RET-He, Hypo-He, IRF, and IG may be useful parameters for identifying subclinical ID in small children with nonsevere acute infection in pediatric outpatients.
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spelling pubmed-103957082023-08-03 Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients KARAKAŞ, Nazmi Mutlu KİRKİZ, Serap KAYA, Zühre Turk J Med Sci Research Article BACKGROUND/AIM: This study aims to investigate the diagnostic utility of new erythrocytes, leukocytes, and reticulocytes parameters for the identification of subclinical iron deficiency (ID) in children under 6 years with nonsevere acute infection in pediatric outpatients. MATERIALS AND METHODS: The study included 102 children with acute infections and 31 true ID. Traditional and new hematology parameters were measured in a Sysmex-XN(®), along with C-reactive protein level, and iron parameters. Participants’ ID were categorized as: the ferritin < 100 ng/mL, transferrin saturation < 20% was defined as “subclinical or functional ID (FID) in Group 1”; ferritin < 30 ng/mL, transferrin saturation < 20%, as “absolute-ID (AID)” in Group 2; ferritin < 12 ng/mL without anemia and infection, as “true ID” in Group 3. RESULTS: The frequencies of FID and AID among the 102 children with acute infection were 24% and 76%, respectively. Compared with the Group 2 patients, Group 1 had a significantly higher mean percentage of hypochromic erythrocytes (Hypo-He), and significantly lower levels of hemoglobin (Hb) and Hb content of reticulocytes (RET-He) (p < 0.05 for all). Compared with Group 2 and Group 3 patients, Group 1 had a significantly higher mean percentage of immature reticulocyte fraction (IRF) and immature granulocyte (IG) values (p < 0.05 for all). The RET-He, IRF%, Hypo-He%, and IG% cut-off values for predicting FID during infection were 27.0 pg, 10.6%, 2.5%, and 0.35% respectively. CONCLUSION: The RET-He, Hypo-He, IRF, and IG may be useful parameters for identifying subclinical ID in small children with nonsevere acute infection in pediatric outpatients. Scientific and Technological Research Council of Turkey (TUBITAK) 2022-05-29 /pmc/articles/PMC10395708/ /pubmed/36422508 http://dx.doi.org/10.55730/1300-0144.5509 Text en © TÜBİTAK https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License.
spellingShingle Research Article
KARAKAŞ, Nazmi Mutlu
KİRKİZ, Serap
KAYA, Zühre
Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients
title Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients
title_full Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients
title_fullStr Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients
title_full_unstemmed Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients
title_short Identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients
title_sort identification of subclinical iron deficiency using new erythrocytes, leukocytes, and reticulocytes parameters during nonsevere acute infection in pediatric outpatients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395708/
https://www.ncbi.nlm.nih.gov/pubmed/36422508
http://dx.doi.org/10.55730/1300-0144.5509
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