Characterisation of putative class 1A DHODH-like proteins from Mucorales and dematiaceous mould species

Olorofim is a new antifungal in clinical development which has a novel mechanism of action against dihydroorotate dehydrogenase (DHODH). DHODH form a ubiquitous family of enzymes in the de novo pyrimidine biosynthetic pathway and are split into class 1A, class 1B and class 2. Olorofim specifically t...

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Detalles Bibliográficos
Autores principales: Pinder, Corinne, Lebedinec, Ressa, Levine, Tim P., Birch, Mike, Oliver, Jason D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395836/
https://www.ncbi.nlm.nih.gov/pubmed/37531380
http://dx.doi.org/10.1371/journal.pone.0289441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395836/
https://www.ncbi.nlm.nih.gov/pubmed/37531380
http://dx.doi.org/10.1371/journal.pone.0289441

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