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Neoplasia sólida pseudopapilar. Reporte de tres casos y revisión de la literatura

BACKGROUND: Solid pseudopapillary neoplasm, or Frantz-Gruber tumor, is a diagnostic challenge for the surgical pathologist. It is classified by the WHO as a malignant epithelial tumor of the pancreas, its prevalence is low, it occurs in only 1 to 2% of all malignant tumors of the pancreas, it usuall...

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Autores principales: Baltazar-Ramos, Javier Iván, Martínez-Reyes, Gabriela, Pérez-Corro, Miguel Ángel, Denis-Rodríguez, Edmundo, Melo-Santiesteban, Guadalupe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Mexicano del Seguro Social 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395929/
https://www.ncbi.nlm.nih.gov/pubmed/37207324
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author Baltazar-Ramos, Javier Iván
Martínez-Reyes, Gabriela
Pérez-Corro, Miguel Ángel
Denis-Rodríguez, Edmundo
Melo-Santiesteban, Guadalupe
author_facet Baltazar-Ramos, Javier Iván
Martínez-Reyes, Gabriela
Pérez-Corro, Miguel Ángel
Denis-Rodríguez, Edmundo
Melo-Santiesteban, Guadalupe
author_sort Baltazar-Ramos, Javier Iván
collection PubMed
description BACKGROUND: Solid pseudopapillary neoplasm, or Frantz-Gruber tumor, is a diagnostic challenge for the surgical pathologist. It is classified by the WHO as a malignant epithelial tumor of the pancreas, its prevalence is low, it occurs in only 1 to 2% of all malignant tumors of the pancreas, it usually affects mainly young women, its origin is still unclear, it is generally It presents as a solitary, encapsulated lesion, without invasion of peripancreatic tissues with rare cases of metastasis, which is why it is considered a low-grade malignant tumor by the WHO. The objective of this article is to present three clinical cases and to evaluate the epidemiology, clinical manifestations, morphology and immunohistochemical expression of the tumor in a review of the bibliography, as well as to compare it with the cases already reported on the subject. CLINICAL CASE: Three cases of Frantz tumor were diagnosed by the pathology department of a tertiary hospital are presented, which correspond to two women aged 17 and 34, as well as a 52-year-old man whose presentation by age and sex is rare. CONCLUSIONS: After the bibliographical review and the analysis of the cases presented, we verified the difficulty to make a correct diagnosis, since its presence is rare in the daily practice of the surgical pathologist. The morphological patterns of the solid pseudopapillary tumor are varied and can often be reminiscent of neuroendocrine tumors of the pancreas, whose presentation rate is higher.
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spelling pubmed-103959292023-08-04 Neoplasia sólida pseudopapilar. Reporte de tres casos y revisión de la literatura Baltazar-Ramos, Javier Iván Martínez-Reyes, Gabriela Pérez-Corro, Miguel Ángel Denis-Rodríguez, Edmundo Melo-Santiesteban, Guadalupe Rev Med Inst Mex Seguro Soc Casos Clínicos BACKGROUND: Solid pseudopapillary neoplasm, or Frantz-Gruber tumor, is a diagnostic challenge for the surgical pathologist. It is classified by the WHO as a malignant epithelial tumor of the pancreas, its prevalence is low, it occurs in only 1 to 2% of all malignant tumors of the pancreas, it usually affects mainly young women, its origin is still unclear, it is generally It presents as a solitary, encapsulated lesion, without invasion of peripancreatic tissues with rare cases of metastasis, which is why it is considered a low-grade malignant tumor by the WHO. The objective of this article is to present three clinical cases and to evaluate the epidemiology, clinical manifestations, morphology and immunohistochemical expression of the tumor in a review of the bibliography, as well as to compare it with the cases already reported on the subject. CLINICAL CASE: Three cases of Frantz tumor were diagnosed by the pathology department of a tertiary hospital are presented, which correspond to two women aged 17 and 34, as well as a 52-year-old man whose presentation by age and sex is rare. CONCLUSIONS: After the bibliographical review and the analysis of the cases presented, we verified the difficulty to make a correct diagnosis, since its presence is rare in the daily practice of the surgical pathologist. The morphological patterns of the solid pseudopapillary tumor are varied and can often be reminiscent of neuroendocrine tumors of the pancreas, whose presentation rate is higher. Instituto Mexicano del Seguro Social 2023 /pmc/articles/PMC10395929/ /pubmed/37207324 Text en © 2023 Revista Medica del Instituto Mexicano del Seguro Social. https://creativecommons.org/licenses/by-nc-nd/4.0/Esta obra está bajo una Licencia Creative Commons Atribución-NoComercial-SinDerivar 4.0 Internacional.
spellingShingle Casos Clínicos
Baltazar-Ramos, Javier Iván
Martínez-Reyes, Gabriela
Pérez-Corro, Miguel Ángel
Denis-Rodríguez, Edmundo
Melo-Santiesteban, Guadalupe
Neoplasia sólida pseudopapilar. Reporte de tres casos y revisión de la literatura
title Neoplasia sólida pseudopapilar. Reporte de tres casos y revisión de la literatura
title_full Neoplasia sólida pseudopapilar. Reporte de tres casos y revisión de la literatura
title_fullStr Neoplasia sólida pseudopapilar. Reporte de tres casos y revisión de la literatura
title_full_unstemmed Neoplasia sólida pseudopapilar. Reporte de tres casos y revisión de la literatura
title_short Neoplasia sólida pseudopapilar. Reporte de tres casos y revisión de la literatura
title_sort neoplasia sólida pseudopapilar. reporte de tres casos y revisión de la literatura
topic Casos Clínicos
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395929/
https://www.ncbi.nlm.nih.gov/pubmed/37207324
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