Cargando…
Activación de sensores del estrés del retículo endoplásmico por dietas asociadas a enfermedades metabólicas y covid-19
The endoplasmic reticulum is an abundant, dynamic and energy-sensing organelle. Its abundant membranes, rough and smooth, are distributed in different proportions depending on the cell lineage and requirement. Its function is to carry out protein and lipid synthesis, and it is the main intracellular...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto Mexicano del Seguro Social
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395978/ https://www.ncbi.nlm.nih.gov/pubmed/35759643 |
_version_ | 1785083700792262656 |
---|---|
author | Cortés-Ginez, María del Carmen Baiza-Gutman, Luis Arturo Manuel-Apolinar, Leticia Cruz-López, Miguel Ibáñez-Hernández, Miguel Ángel Díaz-Flores, Margarita |
author_facet | Cortés-Ginez, María del Carmen Baiza-Gutman, Luis Arturo Manuel-Apolinar, Leticia Cruz-López, Miguel Ibáñez-Hernández, Miguel Ángel Díaz-Flores, Margarita |
author_sort | Cortés-Ginez, María del Carmen |
collection | PubMed |
description | The endoplasmic reticulum is an abundant, dynamic and energy-sensing organelle. Its abundant membranes, rough and smooth, are distributed in different proportions depending on the cell lineage and requirement. Its function is to carry out protein and lipid synthesis, and it is the main intracellular Ca2+ store. Caloric overload and glycolipotoxicity generated by hypercaloric diets cause alteration of the endoplasmic reticulum, activating the Unfolded Protein Response (UPR) as a reaction to cellular stress related to the endoplasmic reticulum and whose objective is to restore the homeostasis of the organelle by decreasing oxidative stress, protein synthesis and Ca2+ leakage. However, during chronic stress, the UPR induces reactive oxygen species formation, inflammation and apoptosis, exacerbating the state of the endoplasmic reticulum and propagating a deleterious effect on the other organelles. This is why endoplasmic reticulum stress has been considered an inducer of the onset and development of metabolic diseases, including the aggravation of COVID-19. So far, few strategies exist to reestablish endoplasmic reticulum homeostasis, which are targeted to sensors that trigger UPR. Therefore, the identification of new mechanisms and novel therapies related to mitigating the impact of endoplasmic reticulum stress and associated complications is urgently warranted. |
format | Online Article Text |
id | pubmed-10395978 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Instituto Mexicano del Seguro Social |
record_format | MEDLINE/PubMed |
spelling | pubmed-103959782023-08-04 Activación de sensores del estrés del retículo endoplásmico por dietas asociadas a enfermedades metabólicas y covid-19 Cortés-Ginez, María del Carmen Baiza-Gutman, Luis Arturo Manuel-Apolinar, Leticia Cruz-López, Miguel Ibáñez-Hernández, Miguel Ángel Díaz-Flores, Margarita Rev Med Inst Mex Seguro Soc Artículo De Revisión The endoplasmic reticulum is an abundant, dynamic and energy-sensing organelle. Its abundant membranes, rough and smooth, are distributed in different proportions depending on the cell lineage and requirement. Its function is to carry out protein and lipid synthesis, and it is the main intracellular Ca2+ store. Caloric overload and glycolipotoxicity generated by hypercaloric diets cause alteration of the endoplasmic reticulum, activating the Unfolded Protein Response (UPR) as a reaction to cellular stress related to the endoplasmic reticulum and whose objective is to restore the homeostasis of the organelle by decreasing oxidative stress, protein synthesis and Ca2+ leakage. However, during chronic stress, the UPR induces reactive oxygen species formation, inflammation and apoptosis, exacerbating the state of the endoplasmic reticulum and propagating a deleterious effect on the other organelles. This is why endoplasmic reticulum stress has been considered an inducer of the onset and development of metabolic diseases, including the aggravation of COVID-19. So far, few strategies exist to reestablish endoplasmic reticulum homeostasis, which are targeted to sensors that trigger UPR. Therefore, the identification of new mechanisms and novel therapies related to mitigating the impact of endoplasmic reticulum stress and associated complications is urgently warranted. Instituto Mexicano del Seguro Social 2022 /pmc/articles/PMC10395978/ /pubmed/35759643 Text en © 2023 Revista Medica del Instituto Mexicano del Seguro Social. https://creativecommons.org/licenses/by-nc-nd/4.0/Esta obra está bajo una Licencia Creative Commons Atribución-NoComercial-SinDerivar 4.0 Internacional. |
spellingShingle | Artículo De Revisión Cortés-Ginez, María del Carmen Baiza-Gutman, Luis Arturo Manuel-Apolinar, Leticia Cruz-López, Miguel Ibáñez-Hernández, Miguel Ángel Díaz-Flores, Margarita Activación de sensores del estrés del retículo endoplásmico por dietas asociadas a enfermedades metabólicas y covid-19 |
title | Activación de sensores del estrés del retículo endoplásmico por dietas asociadas a enfermedades metabólicas y covid-19 |
title_full | Activación de sensores del estrés del retículo endoplásmico por dietas asociadas a enfermedades metabólicas y covid-19 |
title_fullStr | Activación de sensores del estrés del retículo endoplásmico por dietas asociadas a enfermedades metabólicas y covid-19 |
title_full_unstemmed | Activación de sensores del estrés del retículo endoplásmico por dietas asociadas a enfermedades metabólicas y covid-19 |
title_short | Activación de sensores del estrés del retículo endoplásmico por dietas asociadas a enfermedades metabólicas y covid-19 |
title_sort | activación de sensores del estrés del retículo endoplásmico por dietas asociadas a enfermedades metabólicas y covid-19 |
topic | Artículo De Revisión |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395978/ https://www.ncbi.nlm.nih.gov/pubmed/35759643 |
work_keys_str_mv | AT cortesginezmariadelcarmen activaciondesensoresdelestresdelreticuloendoplasmicopordietasasociadasaenfermedadesmetabolicasycovid19 AT baizagutmanluisarturo activaciondesensoresdelestresdelreticuloendoplasmicopordietasasociadasaenfermedadesmetabolicasycovid19 AT manuelapolinarleticia activaciondesensoresdelestresdelreticuloendoplasmicopordietasasociadasaenfermedadesmetabolicasycovid19 AT cruzlopezmiguel activaciondesensoresdelestresdelreticuloendoplasmicopordietasasociadasaenfermedadesmetabolicasycovid19 AT ibanezhernandezmiguelangel activaciondesensoresdelestresdelreticuloendoplasmicopordietasasociadasaenfermedadesmetabolicasycovid19 AT diazfloresmargarita activaciondesensoresdelestresdelreticuloendoplasmicopordietasasociadasaenfermedadesmetabolicasycovid19 |