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Asociando factores pronósticos con resultados clínicos en cáncer de mama localmente avanzado
BACKGROUND: Breast cancer is the most frequent malignant tumor in women. OBJECTIVE: To identify clinico-pathological and molecular markers as predictors of survival in patients with locally advanced breast cancer (LABC). METHODS: Retrospective and observational study. The clinical factors of clinico...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto Mexicano del Seguro Social
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395981/ https://www.ncbi.nlm.nih.gov/pubmed/36542781 |
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author | Ramírez-Torres, Nicolás Reyes-López, Alfonso Hernández-Valencia, Marcelino |
author_facet | Ramírez-Torres, Nicolás Reyes-López, Alfonso Hernández-Valencia, Marcelino |
author_sort | Ramírez-Torres, Nicolás |
collection | PubMed |
description | BACKGROUND: Breast cancer is the most frequent malignant tumor in women. OBJECTIVE: To identify clinico-pathological and molecular markers as predictors of survival in patients with locally advanced breast cancer (LABC). METHODS: Retrospective and observational study. The clinical factors of clinico-pathological and molecular predictors in relation with overall survival (OS) were assessed by the survival function, baseline hazard with smoothing and Cox regression. RESULTS: 126 patients were assessed. OS at five years was significantly superior in patients with clinical stage IIIA (87%; p < 0.001), grade 2 tumor (81%; p < 0.001), pathological node stage (ypN0: 90%; p < .001), low-risk Nottingham prognostic index (86%; p < 0.001) and luminal A subtype (88%; p = 0.022). Baseline hazard with smoothing exhibited an increase in the mortality rate at 50 months for the luminal B/ HER2+ subtype compared with other subtypes. The multivariate analysis ascertained that the stage ypN2-3 (hazard ratio [HR] = 7.3; 95% confidence interval [95% CI]: 2.2 to 23.9) and the HER2+ nonluminal (HR = 7.8; 95% CI: 2 to 29.6) and triple negative (HR = 5.4; 95% CI: 1.7 to 17.2) subtypes were associated with a poor OS. CONCLUSIONS: The comprehensive evaluation of the molecular marker and clinico-pathological factors provides more accurate predictive and prognostic information. The nodal stage and molecular subtype are suitable clinical parameters on survival for LABC patients. |
format | Online Article Text |
id | pubmed-10395981 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Instituto Mexicano del Seguro Social |
record_format | MEDLINE/PubMed |
spelling | pubmed-103959812023-08-04 Asociando factores pronósticos con resultados clínicos en cáncer de mama localmente avanzado Ramírez-Torres, Nicolás Reyes-López, Alfonso Hernández-Valencia, Marcelino Rev Med Inst Mex Seguro Soc Aportación Original BACKGROUND: Breast cancer is the most frequent malignant tumor in women. OBJECTIVE: To identify clinico-pathological and molecular markers as predictors of survival in patients with locally advanced breast cancer (LABC). METHODS: Retrospective and observational study. The clinical factors of clinico-pathological and molecular predictors in relation with overall survival (OS) were assessed by the survival function, baseline hazard with smoothing and Cox regression. RESULTS: 126 patients were assessed. OS at five years was significantly superior in patients with clinical stage IIIA (87%; p < 0.001), grade 2 tumor (81%; p < 0.001), pathological node stage (ypN0: 90%; p < .001), low-risk Nottingham prognostic index (86%; p < 0.001) and luminal A subtype (88%; p = 0.022). Baseline hazard with smoothing exhibited an increase in the mortality rate at 50 months for the luminal B/ HER2+ subtype compared with other subtypes. The multivariate analysis ascertained that the stage ypN2-3 (hazard ratio [HR] = 7.3; 95% confidence interval [95% CI]: 2.2 to 23.9) and the HER2+ nonluminal (HR = 7.8; 95% CI: 2 to 29.6) and triple negative (HR = 5.4; 95% CI: 1.7 to 17.2) subtypes were associated with a poor OS. CONCLUSIONS: The comprehensive evaluation of the molecular marker and clinico-pathological factors provides more accurate predictive and prognostic information. The nodal stage and molecular subtype are suitable clinical parameters on survival for LABC patients. Instituto Mexicano del Seguro Social 2023 /pmc/articles/PMC10395981/ /pubmed/36542781 Text en © 2023 Revista Médica del Instituto Mexicano del Seguro Social. https://creativecommons.org/licenses/by-nc-nd/4.0/Esta obra está bajo una Licencia Creative Commons Atribución-NoComercial-SinDerivar 4.0 Internacional. |
spellingShingle | Aportación Original Ramírez-Torres, Nicolás Reyes-López, Alfonso Hernández-Valencia, Marcelino Asociando factores pronósticos con resultados clínicos en cáncer de mama localmente avanzado |
title | Asociando factores pronósticos con resultados clínicos en cáncer de mama localmente avanzado |
title_full | Asociando factores pronósticos con resultados clínicos en cáncer de mama localmente avanzado |
title_fullStr | Asociando factores pronósticos con resultados clínicos en cáncer de mama localmente avanzado |
title_full_unstemmed | Asociando factores pronósticos con resultados clínicos en cáncer de mama localmente avanzado |
title_short | Asociando factores pronósticos con resultados clínicos en cáncer de mama localmente avanzado |
title_sort | asociando factores pronósticos con resultados clínicos en cáncer de mama localmente avanzado |
topic | Aportación Original |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395981/ https://www.ncbi.nlm.nih.gov/pubmed/36542781 |
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