Cargando…
Características clínicas asociadas a mortalidad por COVID-19 en cuidados intensivos
BACKGROUND: The COVID-19 pandemic caused hospital reconversion throughout Mexico and there was scarce information about its development in second-level intensive care units (ICU). OBJECTIVE: To determine the clinical characteristics related to COVID-19 mortality in a second-level ICU. MATERIAL AND M...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto Mexicano del Seguro Social
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10396017/ https://www.ncbi.nlm.nih.gov/pubmed/35759745 |
_version_ | 1785083710405607424 |
---|---|
author | López-Valdés, Josué Israel Ponce-Mendoza, Rubén Alejandro Solís-Barraza, Miguel Trevizo-Díaz, Juan Luis Nevarez-Campos, Jesús Roberto |
author_facet | López-Valdés, Josué Israel Ponce-Mendoza, Rubén Alejandro Solís-Barraza, Miguel Trevizo-Díaz, Juan Luis Nevarez-Campos, Jesús Roberto |
author_sort | López-Valdés, Josué Israel |
collection | PubMed |
description | BACKGROUND: The COVID-19 pandemic caused hospital reconversion throughout Mexico and there was scarce information about its development in second-level intensive care units (ICU). OBJECTIVE: To determine the clinical characteristics related to COVID-19 mortality in a second-level ICU. MATERIAL AND METHODS: Observational, cohort, retrospective, and analytical study. Demographic variables, medical history, as well as clinical, ventilatory and laboratory characteristics, and complications of patients admitted to ICU from March to November 2020 due to acute respiratory failure were recorded. Patients were divided into two groups: improvement or death. Lost data were imputed by normal multivariated regression. Descriptive statistics and inferencial analysis were made to determine the risk of significant variables against the death outcome with Cox regression. RESULTS: 60% of patients were male. In-hospital mortality was 55%. An older age (44.4 ± 12.1 vs. 50.7 ± 12.1, p = 0.01), higher APACHE II score (8 (10-13) vs. 15 (11-21), p < 0.001), larger onset-symptom time to ICU (10.1 ± 4.0 vs. 12.0 ± 5.3 days, p = 0.049) and a lower oxygen saturation (78.2 ± 16.%5 vs. 71.1 ± 17.9%, p = 0.017) were significantly asociated characteristics to mortality. Average of stay at ICU was 8 days. CONCLUSIONS: A higher age, more days from beginning of symptoms to hospital admission, and lower oxygenation at admission were pre-admission determining factors for risk of death, while cardiovascular, renal complications and hyperglycemia were the in-hospital determinants. |
format | Online Article Text |
id | pubmed-10396017 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Instituto Mexicano del Seguro Social |
record_format | MEDLINE/PubMed |
spelling | pubmed-103960172023-08-04 Características clínicas asociadas a mortalidad por COVID-19 en cuidados intensivos López-Valdés, Josué Israel Ponce-Mendoza, Rubén Alejandro Solís-Barraza, Miguel Trevizo-Díaz, Juan Luis Nevarez-Campos, Jesús Roberto Rev Med Inst Mex Seguro Soc Aportación Original BACKGROUND: The COVID-19 pandemic caused hospital reconversion throughout Mexico and there was scarce information about its development in second-level intensive care units (ICU). OBJECTIVE: To determine the clinical characteristics related to COVID-19 mortality in a second-level ICU. MATERIAL AND METHODS: Observational, cohort, retrospective, and analytical study. Demographic variables, medical history, as well as clinical, ventilatory and laboratory characteristics, and complications of patients admitted to ICU from March to November 2020 due to acute respiratory failure were recorded. Patients were divided into two groups: improvement or death. Lost data were imputed by normal multivariated regression. Descriptive statistics and inferencial analysis were made to determine the risk of significant variables against the death outcome with Cox regression. RESULTS: 60% of patients were male. In-hospital mortality was 55%. An older age (44.4 ± 12.1 vs. 50.7 ± 12.1, p = 0.01), higher APACHE II score (8 (10-13) vs. 15 (11-21), p < 0.001), larger onset-symptom time to ICU (10.1 ± 4.0 vs. 12.0 ± 5.3 days, p = 0.049) and a lower oxygen saturation (78.2 ± 16.%5 vs. 71.1 ± 17.9%, p = 0.017) were significantly asociated characteristics to mortality. Average of stay at ICU was 8 days. CONCLUSIONS: A higher age, more days from beginning of symptoms to hospital admission, and lower oxygenation at admission were pre-admission determining factors for risk of death, while cardiovascular, renal complications and hyperglycemia were the in-hospital determinants. Instituto Mexicano del Seguro Social 2022 /pmc/articles/PMC10396017/ /pubmed/35759745 Text en © 2023 Revista Medica del Instituto Mexicano del Seguro Social. https://creativecommons.org/licenses/by-nc-nd/4.0/Esta obra está bajo una Licencia Creative Commons Atribución-NoComercial-SinDerivar 4.0 Internacional. |
spellingShingle | Aportación Original López-Valdés, Josué Israel Ponce-Mendoza, Rubén Alejandro Solís-Barraza, Miguel Trevizo-Díaz, Juan Luis Nevarez-Campos, Jesús Roberto Características clínicas asociadas a mortalidad por COVID-19 en cuidados intensivos |
title | Características clínicas asociadas a mortalidad por COVID-19 en cuidados intensivos |
title_full | Características clínicas asociadas a mortalidad por COVID-19 en cuidados intensivos |
title_fullStr | Características clínicas asociadas a mortalidad por COVID-19 en cuidados intensivos |
title_full_unstemmed | Características clínicas asociadas a mortalidad por COVID-19 en cuidados intensivos |
title_short | Características clínicas asociadas a mortalidad por COVID-19 en cuidados intensivos |
title_sort | características clínicas asociadas a mortalidad por covid-19 en cuidados intensivos |
topic | Aportación Original |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10396017/ https://www.ncbi.nlm.nih.gov/pubmed/35759745 |
work_keys_str_mv | AT lopezvaldesjosueisrael caracteristicasclinicasasociadasamortalidadporcovid19encuidadosintensivos AT poncemendozarubenalejandro caracteristicasclinicasasociadasamortalidadporcovid19encuidadosintensivos AT solisbarrazamiguel caracteristicasclinicasasociadasamortalidadporcovid19encuidadosintensivos AT trevizodiazjuanluis caracteristicasclinicasasociadasamortalidadporcovid19encuidadosintensivos AT nevarezcamposjesusroberto caracteristicasclinicasasociadasamortalidadporcovid19encuidadosintensivos |