Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia

Pneumonia elicits the production of cytotoxic beta amyloid (Aβ) that contributes to end-organ dysfunction, yet the mechanism(s) linking infection to activation of the amyloidogenic pathway that produces cytotoxic Aβ is unknown. Here, we tested the hypothesis that gamma-secretase activating protein (...

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Detalles Bibliográficos
Autores principales: Gwin, Meredith S., Alexeyev, Mikhail F., Geurts, Aron M., Lee, Ji Young, Zhou, Chun, Yang, Xi-Ming, Cohen, Michael V., Downey, James M., Barrington, Robert A., Spadafora, Domenico, Audia, Jonathon P., Frank, Dara W., Voth, Sarah, Pastukh, Viktoriya V., Bell, Jessica, Ayers, Linn, Tambe, Dhananjay T., Nelson, Amy R., Balczon, Ron, Lin, Mike T., Stevens, Troy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10396227/
https://www.ncbi.nlm.nih.gov/pubmed/37366533
http://dx.doi.org/10.1152/ajplung.00018.2023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10396227/
https://www.ncbi.nlm.nih.gov/pubmed/37366533
http://dx.doi.org/10.1152/ajplung.00018.2023

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