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Clinicopathological characteristics and postoperative prognosis of patients with nuclear pedigree of esophageal squamous cell carcinoma

The aim of this work is to analyze the clinicopathological characteristics and prognostic factors of patients with nuclear pedigree of esophageal cancer. The clinicopathological data and follow-up information of 3,260 patients from different nuclear pedigree of esophageal cancer who underwent radica...

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Autores principales: Wei, Meng Xia, Song, Xin, Zhao, Xue Ke, Han, Wen Li, Bao, Qi De, Han, Xue Nan, Xu, Rui Hua, Li, Xin Min, Fan, Zong Min, Wang, Ran, Li, Xing Song, Hu, Jing Feng, Li, Jia, Li, Bei, Tan, Hui Fang, Gao, She Gan, Zhou, Fu You, Wang, Li Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10396289/
https://www.ncbi.nlm.nih.gov/pubmed/37538122
http://dx.doi.org/10.3389/fonc.2023.1190457
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author Wei, Meng Xia
Song, Xin
Zhao, Xue Ke
Han, Wen Li
Bao, Qi De
Han, Xue Nan
Xu, Rui Hua
Li, Xin Min
Fan, Zong Min
Wang, Ran
Li, Xing Song
Hu, Jing Feng
Li, Jia
Li, Bei
Tan, Hui Fang
Gao, She Gan
Zhou, Fu You
Wang, Li Dong
author_facet Wei, Meng Xia
Song, Xin
Zhao, Xue Ke
Han, Wen Li
Bao, Qi De
Han, Xue Nan
Xu, Rui Hua
Li, Xin Min
Fan, Zong Min
Wang, Ran
Li, Xing Song
Hu, Jing Feng
Li, Jia
Li, Bei
Tan, Hui Fang
Gao, She Gan
Zhou, Fu You
Wang, Li Dong
author_sort Wei, Meng Xia
collection PubMed
description The aim of this work is to analyze the clinicopathological characteristics and prognostic factors of patients with nuclear pedigree of esophageal cancer. The clinicopathological data and follow-up information of 3,260 patients from different nuclear pedigree of esophageal cancer who underwent radical resection of esophageal cancer were collected, and the clinicopathological characteristics and prognostic factors of the patients were analyzed. The male to female ratio of 3,260 patients with esophageal cancer was 1.7:1. The diagnosis age was ranged from 32 to 85 (60.2 ± 8.1) years old. About 53.8% of the patients were ≥ 60 years old; About 88.8% of the patients came from the high incidence area of esophageal cancer; About 82.5% of the tumors were located in the middle and lower segments of esophagus; Poor, moderate and well differentiation accounted for 26.6%, 61.9% and 11.5% respectively; The surgical margin accounted for 94.3%; 47.6% of the tumors were shorter than 4 cm in length; Clinicopathological TNM stage (0+I) accounted for 15.2%, and stage II, III and IV accounted for 54.5%, 29.9% and 0.4%, respectively. Cox analysis showed that male, diagnosed age ≥ 60 years, tumor located in neck and upper esophageal segments, poor differentiation, tumor length ≥ 4 cm, and advanced TNM were independent risk factors for the prognosis of patients in nuclear pedigree with esophageal cancer. Gender, diagnosis age, tumor location, degree of differentiation, tumor length and TNM stage are the influencing factors for the prognosis of patients with nuclear pedigree of esophageal cancer, which will provide important data for the future study of esophageal cancer family aggregation.
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spelling pubmed-103962892023-08-03 Clinicopathological characteristics and postoperative prognosis of patients with nuclear pedigree of esophageal squamous cell carcinoma Wei, Meng Xia Song, Xin Zhao, Xue Ke Han, Wen Li Bao, Qi De Han, Xue Nan Xu, Rui Hua Li, Xin Min Fan, Zong Min Wang, Ran Li, Xing Song Hu, Jing Feng Li, Jia Li, Bei Tan, Hui Fang Gao, She Gan Zhou, Fu You Wang, Li Dong Front Oncol Oncology The aim of this work is to analyze the clinicopathological characteristics and prognostic factors of patients with nuclear pedigree of esophageal cancer. The clinicopathological data and follow-up information of 3,260 patients from different nuclear pedigree of esophageal cancer who underwent radical resection of esophageal cancer were collected, and the clinicopathological characteristics and prognostic factors of the patients were analyzed. The male to female ratio of 3,260 patients with esophageal cancer was 1.7:1. The diagnosis age was ranged from 32 to 85 (60.2 ± 8.1) years old. About 53.8% of the patients were ≥ 60 years old; About 88.8% of the patients came from the high incidence area of esophageal cancer; About 82.5% of the tumors were located in the middle and lower segments of esophagus; Poor, moderate and well differentiation accounted for 26.6%, 61.9% and 11.5% respectively; The surgical margin accounted for 94.3%; 47.6% of the tumors were shorter than 4 cm in length; Clinicopathological TNM stage (0+I) accounted for 15.2%, and stage II, III and IV accounted for 54.5%, 29.9% and 0.4%, respectively. Cox analysis showed that male, diagnosed age ≥ 60 years, tumor located in neck and upper esophageal segments, poor differentiation, tumor length ≥ 4 cm, and advanced TNM were independent risk factors for the prognosis of patients in nuclear pedigree with esophageal cancer. Gender, diagnosis age, tumor location, degree of differentiation, tumor length and TNM stage are the influencing factors for the prognosis of patients with nuclear pedigree of esophageal cancer, which will provide important data for the future study of esophageal cancer family aggregation. Frontiers Media S.A. 2023-07-19 /pmc/articles/PMC10396289/ /pubmed/37538122 http://dx.doi.org/10.3389/fonc.2023.1190457 Text en Copyright © 2023 Wei, Song, Zhao, Han, Bao, Han, Xu, Li, Fan, Wang, Li, Hu, Li, Li, Tan, Gao, Zhou and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wei, Meng Xia
Song, Xin
Zhao, Xue Ke
Han, Wen Li
Bao, Qi De
Han, Xue Nan
Xu, Rui Hua
Li, Xin Min
Fan, Zong Min
Wang, Ran
Li, Xing Song
Hu, Jing Feng
Li, Jia
Li, Bei
Tan, Hui Fang
Gao, She Gan
Zhou, Fu You
Wang, Li Dong
Clinicopathological characteristics and postoperative prognosis of patients with nuclear pedigree of esophageal squamous cell carcinoma
title Clinicopathological characteristics and postoperative prognosis of patients with nuclear pedigree of esophageal squamous cell carcinoma
title_full Clinicopathological characteristics and postoperative prognosis of patients with nuclear pedigree of esophageal squamous cell carcinoma
title_fullStr Clinicopathological characteristics and postoperative prognosis of patients with nuclear pedigree of esophageal squamous cell carcinoma
title_full_unstemmed Clinicopathological characteristics and postoperative prognosis of patients with nuclear pedigree of esophageal squamous cell carcinoma
title_short Clinicopathological characteristics and postoperative prognosis of patients with nuclear pedigree of esophageal squamous cell carcinoma
title_sort clinicopathological characteristics and postoperative prognosis of patients with nuclear pedigree of esophageal squamous cell carcinoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10396289/
https://www.ncbi.nlm.nih.gov/pubmed/37538122
http://dx.doi.org/10.3389/fonc.2023.1190457
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