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A succinate/SUCNR1-brush cell defense program in the tracheal epithelium

Host-derived succinate accumulates in the airways during bacterial infection. Here, we show that luminal succinate activates murine tracheal brush (tuft) cells through a signaling cascade involving the succinate receptor 1 (SUCNR1), phospholipase Cβ2, and the cation channel transient receptor potent...

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Detalles Bibliográficos
Autores principales:	Perniss, Alexander, Boonen, Brett, Tonack, Sarah, Thiel, Moritz, Poharkar, Krupali, Alnouri, Mohamad Wessam, Keshavarz, Maryam, Papadakis, Tamara, Wiegand, Silke, Pfeil, Uwe, Richter, Katrin, Althaus, Mike, Oberwinkler, Johannes, Schütz, Burkhard, Boehm, Ulrich, Offermanns, Stefan, Leinders-Zufall, Trese, Zufall, Frank, Kummer, Wolfgang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10396310/ https://www.ncbi.nlm.nih.gov/pubmed/37531421 http://dx.doi.org/10.1126/sciadv.adg8842

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