The opioid tramadol blocks the cardiac sodium channel Na(v)1.5 in HEK293 cells

AIMS: Opioids are associated with increased risk of sudden cardiac death. This may be due to their effects on the cardiac sodium channel (Na(v)1.5) current. In the present study, we aim to establish whether tramadol, fentanyl, or codeine affects Na(v)1.5 current. METHODS AND RESULTS: Using whole-cel...

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Detalles Bibliográficos
Autores principales: Jia, Lixia, Veldkamp, Marieke W, Verkerk, Arie O, Tan, Hanno L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10396326/
https://www.ncbi.nlm.nih.gov/pubmed/37433113
http://dx.doi.org/10.1093/europace/euad209

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