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Establishing a single-sex controlled human Schistosoma mansoni infection model for Uganda: protocol for safety and dose-finding trial

Control of schistosomiasis depends on a single drug, praziquantel, with variable cure rates, high reinfection rates, and risk of drug resistance. A vaccine could transform schistosomiasis control. Preclinical data show that vaccine development is possible, but conventional vaccine efficacy trials re...

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Detalles Bibliográficos
Autores principales:	Abaasa, Andrew, Egesa, Moses, Driciru, Emmanuella, Koopman, Jan Pieter R, Kiyemba, Ronald, Sanya, Richard E, Nassuuna, Jacent, Ssali, Agnes, Kimbugwe, Geofrey, Wajja, Anne, van Dam, Govert J, Corstjens, Paul L A M, Cose, Stephen, Seeley, Janet, Kamuya, Dorcas, Webb, Emily L, Yazdanbakhsh, Maria, Kaleebu, Pontiano, Siddiqui, Afzal A, Kabatereine, Narcis, Tukahebwa, Edridah, Roestenberg, Meta, Elliott, Alison M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Human Challenge Models
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10396375/ https://www.ncbi.nlm.nih.gov/pubmed/37538934 http://dx.doi.org/10.1093/immadv/ltad010

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