An empirical investigation into the impact of winner’s curse on estimates from Mendelian randomization

INTRODUCTION: Genetic associations for variants identified through genome-wide association studies (GWASs) tend to be overestimated in the original discovery data set as, if the association was underestimated, the variant may not have been detected. This bias, known as winner’s curse, can affect Men...

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Detalles Bibliográficos
Autores principales: Jiang, Tao, Gill, Dipender, Butterworth, Adam S, Burgess, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10396423/
https://www.ncbi.nlm.nih.gov/pubmed/36573802
http://dx.doi.org/10.1093/ije/dyac233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10396423/
https://www.ncbi.nlm.nih.gov/pubmed/36573802
http://dx.doi.org/10.1093/ije/dyac233

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