A case of squamous cell carcinoma of the breast achieved a pathological complete response after dose-dense AC + dose-dense PTX

BACKGROUND: Squamous cell carcinoma (SCC) of the breast is a rare form of breast cancer, accounting for approximately 0.1% of all breast cancers. It is known for its rapid tumor growth and poor prognosis with no established treatment. CASE PRESENTATION: A 56-year-old woman was diagnosed with breast...

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Detalles Bibliográficos
Autores principales: Araki, Misato, Matsui, Koshi, Takagi, Kohji, Kanaya, Emi, Sekine, Shinichi, Nagasawa, Shiho, Watanabe, Toru, Miwa, Takeshi, Hirano, Katsuhisa, Igarashi, Takamichi, Tanaka, Haruyoshi, Shibuya, Kazuto, Hashimoto, Isaya, Hojo, Shozo, Yoshioka, Isaku, Okumura, Tomoyuki, Hirabayashi, Kenichi, Fujii, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397160/
https://www.ncbi.nlm.nih.gov/pubmed/37530896
http://dx.doi.org/10.1186/s40792-023-01719-3
Descripción
Sumario:BACKGROUND: Squamous cell carcinoma (SCC) of the breast is a rare form of breast cancer, accounting for approximately 0.1% of all breast cancers. It is known for its rapid tumor growth and poor prognosis with no established treatment. CASE PRESENTATION: A 56-year-old woman was diagnosed with breast SCC with axillary, supraclavicular and internal thoracic lymph node metastases. She received neoadjuvant chemotherapy (NAC) with dose-dense doxorubicin and cyclophosphamide (AC) followed by dose-dense paclitaxel (PTX). This treatment resulted in a pathological complete response (pCR) after breast-conserving surgery. The patient was then treated with radiotherapy. She remained free of recurrence for three years postoperatively. CONCLUSIONS: We report a rare case of breast SCC treated with preoperative dose-dense chemotherapy, resulting in pCR and allowing breast-conserving surgery.

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