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A case of squamous cell carcinoma of the breast achieved a pathological complete response after dose-dense AC + dose-dense PTX
BACKGROUND: Squamous cell carcinoma (SCC) of the breast is a rare form of breast cancer, accounting for approximately 0.1% of all breast cancers. It is known for its rapid tumor growth and poor prognosis with no established treatment. CASE PRESENTATION: A 56-year-old woman was diagnosed with breast...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Berlin Heidelberg
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397160/ https://www.ncbi.nlm.nih.gov/pubmed/37530896 http://dx.doi.org/10.1186/s40792-023-01719-3 |
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| author | Araki, Misato Matsui, Koshi Takagi, Kohji Kanaya, Emi Sekine, Shinichi Nagasawa, Shiho Watanabe, Toru Miwa, Takeshi Hirano, Katsuhisa Igarashi, Takamichi Tanaka, Haruyoshi Shibuya, Kazuto Hashimoto, Isaya Hojo, Shozo Yoshioka, Isaku Okumura, Tomoyuki Hirabayashi, Kenichi Fujii, Tsutomu |
| author_facet | Araki, Misato Matsui, Koshi Takagi, Kohji Kanaya, Emi Sekine, Shinichi Nagasawa, Shiho Watanabe, Toru Miwa, Takeshi Hirano, Katsuhisa Igarashi, Takamichi Tanaka, Haruyoshi Shibuya, Kazuto Hashimoto, Isaya Hojo, Shozo Yoshioka, Isaku Okumura, Tomoyuki Hirabayashi, Kenichi Fujii, Tsutomu |
| author_sort | Araki, Misato |
| collection | PubMed |
| description | BACKGROUND: Squamous cell carcinoma (SCC) of the breast is a rare form of breast cancer, accounting for approximately 0.1% of all breast cancers. It is known for its rapid tumor growth and poor prognosis with no established treatment. CASE PRESENTATION: A 56-year-old woman was diagnosed with breast SCC with axillary, supraclavicular and internal thoracic lymph node metastases. She received neoadjuvant chemotherapy (NAC) with dose-dense doxorubicin and cyclophosphamide (AC) followed by dose-dense paclitaxel (PTX). This treatment resulted in a pathological complete response (pCR) after breast-conserving surgery. The patient was then treated with radiotherapy. She remained free of recurrence for three years postoperatively. CONCLUSIONS: We report a rare case of breast SCC treated with preoperative dose-dense chemotherapy, resulting in pCR and allowing breast-conserving surgery. |
| format | Online Article Text |
| id | pubmed-10397160 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Springer Berlin Heidelberg |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-103971602023-08-04 A case of squamous cell carcinoma of the breast achieved a pathological complete response after dose-dense AC + dose-dense PTX Araki, Misato Matsui, Koshi Takagi, Kohji Kanaya, Emi Sekine, Shinichi Nagasawa, Shiho Watanabe, Toru Miwa, Takeshi Hirano, Katsuhisa Igarashi, Takamichi Tanaka, Haruyoshi Shibuya, Kazuto Hashimoto, Isaya Hojo, Shozo Yoshioka, Isaku Okumura, Tomoyuki Hirabayashi, Kenichi Fujii, Tsutomu Surg Case Rep Case Report BACKGROUND: Squamous cell carcinoma (SCC) of the breast is a rare form of breast cancer, accounting for approximately 0.1% of all breast cancers. It is known for its rapid tumor growth and poor prognosis with no established treatment. CASE PRESENTATION: A 56-year-old woman was diagnosed with breast SCC with axillary, supraclavicular and internal thoracic lymph node metastases. She received neoadjuvant chemotherapy (NAC) with dose-dense doxorubicin and cyclophosphamide (AC) followed by dose-dense paclitaxel (PTX). This treatment resulted in a pathological complete response (pCR) after breast-conserving surgery. The patient was then treated with radiotherapy. She remained free of recurrence for three years postoperatively. CONCLUSIONS: We report a rare case of breast SCC treated with preoperative dose-dense chemotherapy, resulting in pCR and allowing breast-conserving surgery. Springer Berlin Heidelberg 2023-08-02 /pmc/articles/PMC10397160/ /pubmed/37530896 http://dx.doi.org/10.1186/s40792-023-01719-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Case Report Araki, Misato Matsui, Koshi Takagi, Kohji Kanaya, Emi Sekine, Shinichi Nagasawa, Shiho Watanabe, Toru Miwa, Takeshi Hirano, Katsuhisa Igarashi, Takamichi Tanaka, Haruyoshi Shibuya, Kazuto Hashimoto, Isaya Hojo, Shozo Yoshioka, Isaku Okumura, Tomoyuki Hirabayashi, Kenichi Fujii, Tsutomu A case of squamous cell carcinoma of the breast achieved a pathological complete response after dose-dense AC + dose-dense PTX |
| title | A case of squamous cell carcinoma of the breast achieved a pathological complete response after dose-dense AC + dose-dense PTX |
| title_full | A case of squamous cell carcinoma of the breast achieved a pathological complete response after dose-dense AC + dose-dense PTX |
| title_fullStr | A case of squamous cell carcinoma of the breast achieved a pathological complete response after dose-dense AC + dose-dense PTX |
| title_full_unstemmed | A case of squamous cell carcinoma of the breast achieved a pathological complete response after dose-dense AC + dose-dense PTX |
| title_short | A case of squamous cell carcinoma of the breast achieved a pathological complete response after dose-dense AC + dose-dense PTX |
| title_sort | case of squamous cell carcinoma of the breast achieved a pathological complete response after dose-dense ac + dose-dense ptx |
| topic | Case Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397160/ https://www.ncbi.nlm.nih.gov/pubmed/37530896 http://dx.doi.org/10.1186/s40792-023-01719-3 |
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