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Role of dendritic cells in MYD88-mediated immune recognition and osteoinduction initiated by the implantation of biomaterials

Bone substitute material implantation has become an important treatment strategy for the repair of oral and maxillofacial bone defects. Recent studies have shown that appropriate inflammatory and immune cells are essential factors in the process of osteoinduction of bone substitute materials. Previo...

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Autores principales: Zhao, Zifan, Zhao, Qin, Chen, Hu, Chen, Fanfan, Wang, Feifei, Tang, Hua, Xia, Haibin, Zhou, Yongsheng, Sun, Yuchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397189/
https://www.ncbi.nlm.nih.gov/pubmed/37532700
http://dx.doi.org/10.1038/s41368-023-00234-3
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author Zhao, Zifan
Zhao, Qin
Chen, Hu
Chen, Fanfan
Wang, Feifei
Tang, Hua
Xia, Haibin
Zhou, Yongsheng
Sun, Yuchun
author_facet Zhao, Zifan
Zhao, Qin
Chen, Hu
Chen, Fanfan
Wang, Feifei
Tang, Hua
Xia, Haibin
Zhou, Yongsheng
Sun, Yuchun
author_sort Zhao, Zifan
collection PubMed
description Bone substitute material implantation has become an important treatment strategy for the repair of oral and maxillofacial bone defects. Recent studies have shown that appropriate inflammatory and immune cells are essential factors in the process of osteoinduction of bone substitute materials. Previous studies have mainly focused on innate immune cells such as macrophages. In our previous work, we found that T lymphocytes, as adaptive immune cells, are also essential in the osteoinduction procedure. As the most important antigen-presenting cell, whether dendritic cells (DCs) can recognize non-antigen biomaterials and participate in osteoinduction was still unclear. In this study, we found that surgical trauma associated with materials implantation induces necrocytosis, and this causes the release of high mobility group protein-1 (HMGB1), which is adsorbed on the surface of bone substitute materials. Subsequently, HMGB1-adsorbed materials were recognized by the TLR4-MYD88-NFκB signal axis of dendritic cells, and the inflammatory response was activated. Finally, activated DCs release regeneration-related chemokines, recruit mesenchymal stem cells, and initiate the osteoinduction process. This study sheds light on the immune-regeneration process after bone substitute materials implantation, points out a potential direction for the development of bone substitute materials, and provides guidance for the development of clinical surgical methods.
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spelling pubmed-103971892023-08-04 Role of dendritic cells in MYD88-mediated immune recognition and osteoinduction initiated by the implantation of biomaterials Zhao, Zifan Zhao, Qin Chen, Hu Chen, Fanfan Wang, Feifei Tang, Hua Xia, Haibin Zhou, Yongsheng Sun, Yuchun Int J Oral Sci Article Bone substitute material implantation has become an important treatment strategy for the repair of oral and maxillofacial bone defects. Recent studies have shown that appropriate inflammatory and immune cells are essential factors in the process of osteoinduction of bone substitute materials. Previous studies have mainly focused on innate immune cells such as macrophages. In our previous work, we found that T lymphocytes, as adaptive immune cells, are also essential in the osteoinduction procedure. As the most important antigen-presenting cell, whether dendritic cells (DCs) can recognize non-antigen biomaterials and participate in osteoinduction was still unclear. In this study, we found that surgical trauma associated with materials implantation induces necrocytosis, and this causes the release of high mobility group protein-1 (HMGB1), which is adsorbed on the surface of bone substitute materials. Subsequently, HMGB1-adsorbed materials were recognized by the TLR4-MYD88-NFκB signal axis of dendritic cells, and the inflammatory response was activated. Finally, activated DCs release regeneration-related chemokines, recruit mesenchymal stem cells, and initiate the osteoinduction process. This study sheds light on the immune-regeneration process after bone substitute materials implantation, points out a potential direction for the development of bone substitute materials, and provides guidance for the development of clinical surgical methods. Nature Publishing Group UK 2023-08-02 /pmc/articles/PMC10397189/ /pubmed/37532700 http://dx.doi.org/10.1038/s41368-023-00234-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zhao, Zifan
Zhao, Qin
Chen, Hu
Chen, Fanfan
Wang, Feifei
Tang, Hua
Xia, Haibin
Zhou, Yongsheng
Sun, Yuchun
Role of dendritic cells in MYD88-mediated immune recognition and osteoinduction initiated by the implantation of biomaterials
title Role of dendritic cells in MYD88-mediated immune recognition and osteoinduction initiated by the implantation of biomaterials
title_full Role of dendritic cells in MYD88-mediated immune recognition and osteoinduction initiated by the implantation of biomaterials
title_fullStr Role of dendritic cells in MYD88-mediated immune recognition and osteoinduction initiated by the implantation of biomaterials
title_full_unstemmed Role of dendritic cells in MYD88-mediated immune recognition and osteoinduction initiated by the implantation of biomaterials
title_short Role of dendritic cells in MYD88-mediated immune recognition and osteoinduction initiated by the implantation of biomaterials
title_sort role of dendritic cells in myd88-mediated immune recognition and osteoinduction initiated by the implantation of biomaterials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397189/
https://www.ncbi.nlm.nih.gov/pubmed/37532700
http://dx.doi.org/10.1038/s41368-023-00234-3
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