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Site-selective superassembly of biomimetic nanorobots enabling deep penetration into tumor with stiff stroma

Chemotherapy remains as the first-choice treatment option for triple-negative breast cancer (TNBC). However, the limited tumor penetration and low cellular internalization efficiency of current nanocarrier-based systems impede the access of anticancer drugs to TNBC with dense stroma and thereby grea...

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Autores principales: Yan, Miao, Chen, Qing, Liu, Tianyi, Li, Xiaofeng, Pei, Peng, Zhou, Lei, Zhou, Shan, Zhang, Runhao, Liang, Kang, Dong, Jian, Wei, Xunbin, Wang, Jinqiang, Terasaki, Osamu, Chen, Pu, Gu, Zhen, Jiang, Libo, Kong, Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397308/
https://www.ncbi.nlm.nih.gov/pubmed/37532754
http://dx.doi.org/10.1038/s41467-023-40300-2
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author Yan, Miao
Chen, Qing
Liu, Tianyi
Li, Xiaofeng
Pei, Peng
Zhou, Lei
Zhou, Shan
Zhang, Runhao
Liang, Kang
Dong, Jian
Wei, Xunbin
Wang, Jinqiang
Terasaki, Osamu
Chen, Pu
Gu, Zhen
Jiang, Libo
Kong, Biao
author_facet Yan, Miao
Chen, Qing
Liu, Tianyi
Li, Xiaofeng
Pei, Peng
Zhou, Lei
Zhou, Shan
Zhang, Runhao
Liang, Kang
Dong, Jian
Wei, Xunbin
Wang, Jinqiang
Terasaki, Osamu
Chen, Pu
Gu, Zhen
Jiang, Libo
Kong, Biao
author_sort Yan, Miao
collection PubMed
description Chemotherapy remains as the first-choice treatment option for triple-negative breast cancer (TNBC). However, the limited tumor penetration and low cellular internalization efficiency of current nanocarrier-based systems impede the access of anticancer drugs to TNBC with dense stroma and thereby greatly restricts clinical therapeutic efficacy, especially for TNBC bone metastasis. In this work, biomimetic head/hollow tail nanorobots were designed through a site-selective superassembly strategy. We show that nanorobots enable efficient remodeling of the dense tumor stromal microenvironments (TSM) for deep tumor penetration. Furthermore, the self-movement ability and spiky head markedly promote interfacial cellular uptake efficacy, transvascular extravasation, and intratumoral penetration. These nanorobots, which integrate deep tumor penetration, active cellular internalization, near-infrared (NIR) light-responsive release, and photothermal therapy capacities into a single nanodevice efficiently suppress tumor growth in a bone metastasis female mouse model of TNBC and also demonstrate potent antitumor efficacy in three different subcutaneous tumor models.
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spelling pubmed-103973082023-08-04 Site-selective superassembly of biomimetic nanorobots enabling deep penetration into tumor with stiff stroma Yan, Miao Chen, Qing Liu, Tianyi Li, Xiaofeng Pei, Peng Zhou, Lei Zhou, Shan Zhang, Runhao Liang, Kang Dong, Jian Wei, Xunbin Wang, Jinqiang Terasaki, Osamu Chen, Pu Gu, Zhen Jiang, Libo Kong, Biao Nat Commun Article Chemotherapy remains as the first-choice treatment option for triple-negative breast cancer (TNBC). However, the limited tumor penetration and low cellular internalization efficiency of current nanocarrier-based systems impede the access of anticancer drugs to TNBC with dense stroma and thereby greatly restricts clinical therapeutic efficacy, especially for TNBC bone metastasis. In this work, biomimetic head/hollow tail nanorobots were designed through a site-selective superassembly strategy. We show that nanorobots enable efficient remodeling of the dense tumor stromal microenvironments (TSM) for deep tumor penetration. Furthermore, the self-movement ability and spiky head markedly promote interfacial cellular uptake efficacy, transvascular extravasation, and intratumoral penetration. These nanorobots, which integrate deep tumor penetration, active cellular internalization, near-infrared (NIR) light-responsive release, and photothermal therapy capacities into a single nanodevice efficiently suppress tumor growth in a bone metastasis female mouse model of TNBC and also demonstrate potent antitumor efficacy in three different subcutaneous tumor models. Nature Publishing Group UK 2023-08-02 /pmc/articles/PMC10397308/ /pubmed/37532754 http://dx.doi.org/10.1038/s41467-023-40300-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Yan, Miao
Chen, Qing
Liu, Tianyi
Li, Xiaofeng
Pei, Peng
Zhou, Lei
Zhou, Shan
Zhang, Runhao
Liang, Kang
Dong, Jian
Wei, Xunbin
Wang, Jinqiang
Terasaki, Osamu
Chen, Pu
Gu, Zhen
Jiang, Libo
Kong, Biao
Site-selective superassembly of biomimetic nanorobots enabling deep penetration into tumor with stiff stroma
title Site-selective superassembly of biomimetic nanorobots enabling deep penetration into tumor with stiff stroma
title_full Site-selective superassembly of biomimetic nanorobots enabling deep penetration into tumor with stiff stroma
title_fullStr Site-selective superassembly of biomimetic nanorobots enabling deep penetration into tumor with stiff stroma
title_full_unstemmed Site-selective superassembly of biomimetic nanorobots enabling deep penetration into tumor with stiff stroma
title_short Site-selective superassembly of biomimetic nanorobots enabling deep penetration into tumor with stiff stroma
title_sort site-selective superassembly of biomimetic nanorobots enabling deep penetration into tumor with stiff stroma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397308/
https://www.ncbi.nlm.nih.gov/pubmed/37532754
http://dx.doi.org/10.1038/s41467-023-40300-2
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