Targeted degradation of MERTK and other TAM receptor paralogs by heterobifunctional targeted protein degraders

TAM receptors (TYRO3, AXL, and MERTK) comprise a family of homologous receptor tyrosine kinases (RTK) that are expressed across a range of liquid and solid tumors where they contribute to both oncogenic signaling to promote tumor proliferation and survival, as well as expressed on myeloid and immune...

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Detalles Bibliográficos
Autores principales: Gadiyar, Varsha, Patel, Gopi, Chen, Jesse, Vigil, Dominico, Ji, Nan, Campbell, Veronica, Sharma, Kirti, Shi, Yatao, Weiss, Matthew M., Birge, Raymond B., Davra, Viralkumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397400/
https://www.ncbi.nlm.nih.gov/pubmed/37545504
http://dx.doi.org/10.3389/fimmu.2023.1135373

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