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The association between HIV infection and precancerous cervical lesion. A systematic review and meta‐analysis of case–control studies
BACKGROUND: The effect of human immunodeficiency virus (HIV) on precancerous cervical lesion is not consistent across studies. Besides to the variability in the presence of a significant association between HIV and precancerous cervical lesion, the reported strengths are inconsistent among studies t...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397473/ https://www.ncbi.nlm.nih.gov/pubmed/37547356 http://dx.doi.org/10.1002/hsr2.1485 |
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author | Geremew, Habtamu Tesfa, Hiwot Mengstie, Misganaw A. Gashu, Chalachew Kassa, Yoseph Negash, Abraham Dessie, Anteneh Mengist Geremew, Demeke |
author_facet | Geremew, Habtamu Tesfa, Hiwot Mengstie, Misganaw A. Gashu, Chalachew Kassa, Yoseph Negash, Abraham Dessie, Anteneh Mengist Geremew, Demeke |
author_sort | Geremew, Habtamu |
collection | PubMed |
description | BACKGROUND: The effect of human immunodeficiency virus (HIV) on precancerous cervical lesion is not consistent across studies. Besides to the variability in the presence of a significant association between HIV and precancerous cervical lesion, the reported strengths are inconsistent among studies that report a significant association. Therefore, we sought to determine the impact of HIV on women's risk of precancerous cervical lesion by conducting a systematic review and meta‐analysis of case–control studies in Ethiopia. METHODS: Relevant articles were systematically searched on African Journals Online, Cochrane Library, Science Direct, Google Scholar, and PubMed from January 1, 2023, to February 20, 2023. After critical appraisal, pertinent data were extracted into an Excel spreadsheet and then exported to STATA 14 for further statistical analysis. The pooled effect size was estimated using the random‐effect model. The Egger's regression test and I (2) statistics were employed to assess publication bias and heterogeneity among included studies, respectively. RESULTS: Ten case–control studies with a total of 3035 participants (992 cases and 2043 controls) were involved in this meta‐analysis. According to our analysis, HIV‐infected women were 2.86 times more likely to develop precancerous cervical lesion as compared with their counterparts (odds ratio: 2.86, 95% confidence interval: 1.79, 4.58). CONCLUSION: We found that HIV‐infected women have a higher risk of precancerous cervical lesion. Thus, targeted screening programs should be considered to reduce the burden of cervical cancer among HIV‐infected women in Ethiopia. |
format | Online Article Text |
id | pubmed-10397473 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103974732023-08-04 The association between HIV infection and precancerous cervical lesion. A systematic review and meta‐analysis of case–control studies Geremew, Habtamu Tesfa, Hiwot Mengstie, Misganaw A. Gashu, Chalachew Kassa, Yoseph Negash, Abraham Dessie, Anteneh Mengist Geremew, Demeke Health Sci Rep Narrative Review BACKGROUND: The effect of human immunodeficiency virus (HIV) on precancerous cervical lesion is not consistent across studies. Besides to the variability in the presence of a significant association between HIV and precancerous cervical lesion, the reported strengths are inconsistent among studies that report a significant association. Therefore, we sought to determine the impact of HIV on women's risk of precancerous cervical lesion by conducting a systematic review and meta‐analysis of case–control studies in Ethiopia. METHODS: Relevant articles were systematically searched on African Journals Online, Cochrane Library, Science Direct, Google Scholar, and PubMed from January 1, 2023, to February 20, 2023. After critical appraisal, pertinent data were extracted into an Excel spreadsheet and then exported to STATA 14 for further statistical analysis. The pooled effect size was estimated using the random‐effect model. The Egger's regression test and I (2) statistics were employed to assess publication bias and heterogeneity among included studies, respectively. RESULTS: Ten case–control studies with a total of 3035 participants (992 cases and 2043 controls) were involved in this meta‐analysis. According to our analysis, HIV‐infected women were 2.86 times more likely to develop precancerous cervical lesion as compared with their counterparts (odds ratio: 2.86, 95% confidence interval: 1.79, 4.58). CONCLUSION: We found that HIV‐infected women have a higher risk of precancerous cervical lesion. Thus, targeted screening programs should be considered to reduce the burden of cervical cancer among HIV‐infected women in Ethiopia. John Wiley and Sons Inc. 2023-08-02 /pmc/articles/PMC10397473/ /pubmed/37547356 http://dx.doi.org/10.1002/hsr2.1485 Text en © 2023 The Authors. Health Science Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Narrative Review Geremew, Habtamu Tesfa, Hiwot Mengstie, Misganaw A. Gashu, Chalachew Kassa, Yoseph Negash, Abraham Dessie, Anteneh Mengist Geremew, Demeke The association between HIV infection and precancerous cervical lesion. A systematic review and meta‐analysis of case–control studies |
title | The association between HIV infection and precancerous cervical lesion. A systematic review and meta‐analysis of case–control studies |
title_full | The association between HIV infection and precancerous cervical lesion. A systematic review and meta‐analysis of case–control studies |
title_fullStr | The association between HIV infection and precancerous cervical lesion. A systematic review and meta‐analysis of case–control studies |
title_full_unstemmed | The association between HIV infection and precancerous cervical lesion. A systematic review and meta‐analysis of case–control studies |
title_short | The association between HIV infection and precancerous cervical lesion. A systematic review and meta‐analysis of case–control studies |
title_sort | association between hiv infection and precancerous cervical lesion. a systematic review and meta‐analysis of case–control studies |
topic | Narrative Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397473/ https://www.ncbi.nlm.nih.gov/pubmed/37547356 http://dx.doi.org/10.1002/hsr2.1485 |
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