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The association between HIV infection and precancerous cervical lesion. A systematic review and meta‐analysis of case–control studies

BACKGROUND: The effect of human immunodeficiency virus (HIV) on precancerous cervical lesion is not consistent across studies. Besides to the variability in the presence of a significant association between HIV and precancerous cervical lesion, the reported strengths are inconsistent among studies t...

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Autores principales: Geremew, Habtamu, Tesfa, Hiwot, Mengstie, Misganaw A., Gashu, Chalachew, Kassa, Yoseph, Negash, Abraham, Dessie, Anteneh Mengist, Geremew, Demeke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397473/
https://www.ncbi.nlm.nih.gov/pubmed/37547356
http://dx.doi.org/10.1002/hsr2.1485
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author Geremew, Habtamu
Tesfa, Hiwot
Mengstie, Misganaw A.
Gashu, Chalachew
Kassa, Yoseph
Negash, Abraham
Dessie, Anteneh Mengist
Geremew, Demeke
author_facet Geremew, Habtamu
Tesfa, Hiwot
Mengstie, Misganaw A.
Gashu, Chalachew
Kassa, Yoseph
Negash, Abraham
Dessie, Anteneh Mengist
Geremew, Demeke
author_sort Geremew, Habtamu
collection PubMed
description BACKGROUND: The effect of human immunodeficiency virus (HIV) on precancerous cervical lesion is not consistent across studies. Besides to the variability in the presence of a significant association between HIV and precancerous cervical lesion, the reported strengths are inconsistent among studies that report a significant association. Therefore, we sought to determine the impact of HIV on women's risk of precancerous cervical lesion by conducting a systematic review and meta‐analysis of case–control studies in Ethiopia. METHODS: Relevant articles were systematically searched on African Journals Online, Cochrane Library, Science Direct, Google Scholar, and PubMed from January 1, 2023, to February 20, 2023. After critical appraisal, pertinent data were extracted into an Excel spreadsheet and then exported to STATA 14 for further statistical analysis. The pooled effect size was estimated using the random‐effect model. The Egger's regression test and I (2) statistics were employed to assess publication bias and heterogeneity among included studies, respectively. RESULTS: Ten case–control studies with a total of 3035 participants (992 cases and 2043 controls) were involved in this meta‐analysis. According to our analysis, HIV‐infected women were 2.86 times more likely to develop precancerous cervical lesion as compared with their counterparts (odds ratio: 2.86, 95% confidence interval: 1.79, 4.58). CONCLUSION: We found that HIV‐infected women have a higher risk of precancerous cervical lesion. Thus, targeted screening programs should be considered to reduce the burden of cervical cancer among HIV‐infected women in Ethiopia.
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spelling pubmed-103974732023-08-04 The association between HIV infection and precancerous cervical lesion. A systematic review and meta‐analysis of case–control studies Geremew, Habtamu Tesfa, Hiwot Mengstie, Misganaw A. Gashu, Chalachew Kassa, Yoseph Negash, Abraham Dessie, Anteneh Mengist Geremew, Demeke Health Sci Rep Narrative Review BACKGROUND: The effect of human immunodeficiency virus (HIV) on precancerous cervical lesion is not consistent across studies. Besides to the variability in the presence of a significant association between HIV and precancerous cervical lesion, the reported strengths are inconsistent among studies that report a significant association. Therefore, we sought to determine the impact of HIV on women's risk of precancerous cervical lesion by conducting a systematic review and meta‐analysis of case–control studies in Ethiopia. METHODS: Relevant articles were systematically searched on African Journals Online, Cochrane Library, Science Direct, Google Scholar, and PubMed from January 1, 2023, to February 20, 2023. After critical appraisal, pertinent data were extracted into an Excel spreadsheet and then exported to STATA 14 for further statistical analysis. The pooled effect size was estimated using the random‐effect model. The Egger's regression test and I (2) statistics were employed to assess publication bias and heterogeneity among included studies, respectively. RESULTS: Ten case–control studies with a total of 3035 participants (992 cases and 2043 controls) were involved in this meta‐analysis. According to our analysis, HIV‐infected women were 2.86 times more likely to develop precancerous cervical lesion as compared with their counterparts (odds ratio: 2.86, 95% confidence interval: 1.79, 4.58). CONCLUSION: We found that HIV‐infected women have a higher risk of precancerous cervical lesion. Thus, targeted screening programs should be considered to reduce the burden of cervical cancer among HIV‐infected women in Ethiopia. John Wiley and Sons Inc. 2023-08-02 /pmc/articles/PMC10397473/ /pubmed/37547356 http://dx.doi.org/10.1002/hsr2.1485 Text en © 2023 The Authors. Health Science Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Narrative Review
Geremew, Habtamu
Tesfa, Hiwot
Mengstie, Misganaw A.
Gashu, Chalachew
Kassa, Yoseph
Negash, Abraham
Dessie, Anteneh Mengist
Geremew, Demeke
The association between HIV infection and precancerous cervical lesion. A systematic review and meta‐analysis of case–control studies
title The association between HIV infection and precancerous cervical lesion. A systematic review and meta‐analysis of case–control studies
title_full The association between HIV infection and precancerous cervical lesion. A systematic review and meta‐analysis of case–control studies
title_fullStr The association between HIV infection and precancerous cervical lesion. A systematic review and meta‐analysis of case–control studies
title_full_unstemmed The association between HIV infection and precancerous cervical lesion. A systematic review and meta‐analysis of case–control studies
title_short The association between HIV infection and precancerous cervical lesion. A systematic review and meta‐analysis of case–control studies
title_sort association between hiv infection and precancerous cervical lesion. a systematic review and meta‐analysis of case–control studies
topic Narrative Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397473/
https://www.ncbi.nlm.nih.gov/pubmed/37547356
http://dx.doi.org/10.1002/hsr2.1485
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