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Epigenetic reprogramming during the maternal‐to‐zygotic transition

After fertilization, sperm and oocyte fused and gave rise to a zygote which is the beginning of a new life. Then the embryonic development is monitored and regulated precisely from the transition of oocyte to the embryo at the early stage of embryogenesis, and this process is termed maternal‐to‐zygo...

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Autores principales: Chen, Yurong, Wang, Luyao, Guo, Fucheng, Dai, Xiangpeng, Zhang, Xiaoling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397483/
https://www.ncbi.nlm.nih.gov/pubmed/37547174
http://dx.doi.org/10.1002/mco2.331
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author Chen, Yurong
Wang, Luyao
Guo, Fucheng
Dai, Xiangpeng
Zhang, Xiaoling
author_facet Chen, Yurong
Wang, Luyao
Guo, Fucheng
Dai, Xiangpeng
Zhang, Xiaoling
author_sort Chen, Yurong
collection PubMed
description After fertilization, sperm and oocyte fused and gave rise to a zygote which is the beginning of a new life. Then the embryonic development is monitored and regulated precisely from the transition of oocyte to the embryo at the early stage of embryogenesis, and this process is termed maternal‐to‐zygotic transition (MZT). MZT involves two major events that are maternal components degradation and zygotic genome activation. The epigenetic reprogramming plays crucial roles in regulating the process of MZT and supervising the normal development of early development of embryos. In recent years, benefited from the rapid development of low‐input epigenome profiling technologies, new epigenetic modifications are found to be reprogrammed dramatically and may play different roles during MZT whose dysregulation will cause an abnormal development of embryos even abortion at various stages. In this review, we summarized and discussed the important novel findings on epigenetic reprogramming and the underlying molecular mechanisms regulating MZT in mammalian embryos. Our work provided comprehensive and detailed references for the in deep understanding of epigenetic regulatory network in this key biological process and also shed light on the critical roles for epigenetic reprogramming on embryonic failure during artificial reproductive technology and nature fertilization.
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spelling pubmed-103974832023-08-04 Epigenetic reprogramming during the maternal‐to‐zygotic transition Chen, Yurong Wang, Luyao Guo, Fucheng Dai, Xiangpeng Zhang, Xiaoling MedComm (2020) Reviews After fertilization, sperm and oocyte fused and gave rise to a zygote which is the beginning of a new life. Then the embryonic development is monitored and regulated precisely from the transition of oocyte to the embryo at the early stage of embryogenesis, and this process is termed maternal‐to‐zygotic transition (MZT). MZT involves two major events that are maternal components degradation and zygotic genome activation. The epigenetic reprogramming plays crucial roles in regulating the process of MZT and supervising the normal development of early development of embryos. In recent years, benefited from the rapid development of low‐input epigenome profiling technologies, new epigenetic modifications are found to be reprogrammed dramatically and may play different roles during MZT whose dysregulation will cause an abnormal development of embryos even abortion at various stages. In this review, we summarized and discussed the important novel findings on epigenetic reprogramming and the underlying molecular mechanisms regulating MZT in mammalian embryos. Our work provided comprehensive and detailed references for the in deep understanding of epigenetic regulatory network in this key biological process and also shed light on the critical roles for epigenetic reprogramming on embryonic failure during artificial reproductive technology and nature fertilization. John Wiley and Sons Inc. 2023-08-02 /pmc/articles/PMC10397483/ /pubmed/37547174 http://dx.doi.org/10.1002/mco2.331 Text en © 2023 The Authors. MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Chen, Yurong
Wang, Luyao
Guo, Fucheng
Dai, Xiangpeng
Zhang, Xiaoling
Epigenetic reprogramming during the maternal‐to‐zygotic transition
title Epigenetic reprogramming during the maternal‐to‐zygotic transition
title_full Epigenetic reprogramming during the maternal‐to‐zygotic transition
title_fullStr Epigenetic reprogramming during the maternal‐to‐zygotic transition
title_full_unstemmed Epigenetic reprogramming during the maternal‐to‐zygotic transition
title_short Epigenetic reprogramming during the maternal‐to‐zygotic transition
title_sort epigenetic reprogramming during the maternal‐to‐zygotic transition
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397483/
https://www.ncbi.nlm.nih.gov/pubmed/37547174
http://dx.doi.org/10.1002/mco2.331
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