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Differential expression of GABA(A) receptor subunits δ and α6 mediates tonic inhibition in parvalbumin and somatostatin interneurons in the mouse hippocampus

Inhibitory γ-aminobutyric acid (GABA)-ergic interneurons mediate inhibition in neuronal circuitry and support normal brain function. Consequently, dysregulation of inhibition is implicated in various brain disorders. Parvalbumin (PV) and somatostatin (SST) interneurons, the two major types of GABAer...

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Autores principales: Huang, Tzu-Hsuan, Lin, Yi-Sian, Hsiao, Chiao-Wan, Wang, Liang-Yun, Ajibola, Musa Iyiola, Abdulmajeed, Wahab Imam, Lin, Yu-Ling, Li, Yu-Jui, Chen, Cho-Yi, Lien, Cheng-Chang, Chiu, Cheng-Di, Cheng, Irene Han-Juo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397515/
https://www.ncbi.nlm.nih.gov/pubmed/37545878
http://dx.doi.org/10.3389/fncel.2023.1146278
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author Huang, Tzu-Hsuan
Lin, Yi-Sian
Hsiao, Chiao-Wan
Wang, Liang-Yun
Ajibola, Musa Iyiola
Abdulmajeed, Wahab Imam
Lin, Yu-Ling
Li, Yu-Jui
Chen, Cho-Yi
Lien, Cheng-Chang
Chiu, Cheng-Di
Cheng, Irene Han-Juo
author_facet Huang, Tzu-Hsuan
Lin, Yi-Sian
Hsiao, Chiao-Wan
Wang, Liang-Yun
Ajibola, Musa Iyiola
Abdulmajeed, Wahab Imam
Lin, Yu-Ling
Li, Yu-Jui
Chen, Cho-Yi
Lien, Cheng-Chang
Chiu, Cheng-Di
Cheng, Irene Han-Juo
author_sort Huang, Tzu-Hsuan
collection PubMed
description Inhibitory γ-aminobutyric acid (GABA)-ergic interneurons mediate inhibition in neuronal circuitry and support normal brain function. Consequently, dysregulation of inhibition is implicated in various brain disorders. Parvalbumin (PV) and somatostatin (SST) interneurons, the two major types of GABAergic inhibitory interneurons in the hippocampus, exhibit distinct morpho-physiological properties and coordinate information processing and memory formation. However, the molecular mechanisms underlying the specialized properties of PV and SST interneurons remain unclear. This study aimed to compare the transcriptomic differences between these two classes of interneurons in the hippocampus using the ribosome tagging approach. The results revealed distinct expressions of genes such as voltage-gated ion channels and GABA(A) receptor subunits between PV and SST interneurons. Gabrd and Gabra6 were identified as contributors to the contrasting tonic GABAergic inhibition observed in PV and SST interneurons. Moreover, some of the differentially expressed genes were associated with schizophrenia and epilepsy. In conclusion, our results provide molecular insights into the distinct roles of PV and SST interneurons in health and disease.
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spelling pubmed-103975152023-08-04 Differential expression of GABA(A) receptor subunits δ and α6 mediates tonic inhibition in parvalbumin and somatostatin interneurons in the mouse hippocampus Huang, Tzu-Hsuan Lin, Yi-Sian Hsiao, Chiao-Wan Wang, Liang-Yun Ajibola, Musa Iyiola Abdulmajeed, Wahab Imam Lin, Yu-Ling Li, Yu-Jui Chen, Cho-Yi Lien, Cheng-Chang Chiu, Cheng-Di Cheng, Irene Han-Juo Front Cell Neurosci Neuroscience Inhibitory γ-aminobutyric acid (GABA)-ergic interneurons mediate inhibition in neuronal circuitry and support normal brain function. Consequently, dysregulation of inhibition is implicated in various brain disorders. Parvalbumin (PV) and somatostatin (SST) interneurons, the two major types of GABAergic inhibitory interneurons in the hippocampus, exhibit distinct morpho-physiological properties and coordinate information processing and memory formation. However, the molecular mechanisms underlying the specialized properties of PV and SST interneurons remain unclear. This study aimed to compare the transcriptomic differences between these two classes of interneurons in the hippocampus using the ribosome tagging approach. The results revealed distinct expressions of genes such as voltage-gated ion channels and GABA(A) receptor subunits between PV and SST interneurons. Gabrd and Gabra6 were identified as contributors to the contrasting tonic GABAergic inhibition observed in PV and SST interneurons. Moreover, some of the differentially expressed genes were associated with schizophrenia and epilepsy. In conclusion, our results provide molecular insights into the distinct roles of PV and SST interneurons in health and disease. Frontiers Media S.A. 2023-07-20 /pmc/articles/PMC10397515/ /pubmed/37545878 http://dx.doi.org/10.3389/fncel.2023.1146278 Text en Copyright © 2023 Huang, Lin, Hsiao, Wang, Ajibola, Abdulmajeed, Lin, Li, Chen, Lien, Chiu and Cheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Huang, Tzu-Hsuan
Lin, Yi-Sian
Hsiao, Chiao-Wan
Wang, Liang-Yun
Ajibola, Musa Iyiola
Abdulmajeed, Wahab Imam
Lin, Yu-Ling
Li, Yu-Jui
Chen, Cho-Yi
Lien, Cheng-Chang
Chiu, Cheng-Di
Cheng, Irene Han-Juo
Differential expression of GABA(A) receptor subunits δ and α6 mediates tonic inhibition in parvalbumin and somatostatin interneurons in the mouse hippocampus
title Differential expression of GABA(A) receptor subunits δ and α6 mediates tonic inhibition in parvalbumin and somatostatin interneurons in the mouse hippocampus
title_full Differential expression of GABA(A) receptor subunits δ and α6 mediates tonic inhibition in parvalbumin and somatostatin interneurons in the mouse hippocampus
title_fullStr Differential expression of GABA(A) receptor subunits δ and α6 mediates tonic inhibition in parvalbumin and somatostatin interneurons in the mouse hippocampus
title_full_unstemmed Differential expression of GABA(A) receptor subunits δ and α6 mediates tonic inhibition in parvalbumin and somatostatin interneurons in the mouse hippocampus
title_short Differential expression of GABA(A) receptor subunits δ and α6 mediates tonic inhibition in parvalbumin and somatostatin interneurons in the mouse hippocampus
title_sort differential expression of gaba(a) receptor subunits δ and α6 mediates tonic inhibition in parvalbumin and somatostatin interneurons in the mouse hippocampus
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10397515/
https://www.ncbi.nlm.nih.gov/pubmed/37545878
http://dx.doi.org/10.3389/fncel.2023.1146278
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