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Predicting Acute Exacerbations in Chronic Obstructive Pulmonary Disease

BACKGROUND: With increasing health care costs that have outpaced those of other industries, payers of health care are moving from a fee-for-service payment model to one in which reimbursement is tied to outcomes. Chronic obstructive pulmonary disease (COPD) is a disease where this payment model has...

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Autores principales: Samp, Jennifer C., Joo, Min J., Schumock, Glen T., Calip, Gregory S., Pickard, A. Simon, Lee, Todd A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academy of Managed Care Pharmacy 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398113/
https://www.ncbi.nlm.nih.gov/pubmed/29485951
http://dx.doi.org/10.18553/jmcp.2018.24.3.265
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author Samp, Jennifer C.
Joo, Min J.
Schumock, Glen T.
Calip, Gregory S.
Pickard, A. Simon
Lee, Todd A.
author_facet Samp, Jennifer C.
Joo, Min J.
Schumock, Glen T.
Calip, Gregory S.
Pickard, A. Simon
Lee, Todd A.
author_sort Samp, Jennifer C.
collection PubMed
description BACKGROUND: With increasing health care costs that have outpaced those of other industries, payers of health care are moving from a fee-for-service payment model to one in which reimbursement is tied to outcomes. Chronic obstructive pulmonary disease (COPD) is a disease where this payment model has been implemented by some payers, and COPD exacerbations are a quality metric that is used. Under an outcomes-based payment model, it is important for health systems to be able to identify patients at risk for poor outcomes so that they can target interventions to improve outcomes. OBJECTIVE: To develop and evaluate predictive models that could be used to identify patients at high risk for COPD exacerbations. METHODS: This study was retrospective and observational and included COPD patients treated with a bronchodilator-based combination therapy. We used health insurance claims data to obtain demographics, enrollment information, comorbidities, medication use, and health care resource utilization for each patient over a 6-month baseline period. Exacerbations were examined over a 6-month outcome period and included inpatient (primary discharge diagnosis for COPD), outpatient, and emergency department (outpatient/emergency department visits with a COPD diagnosis plus an acute prescription for an antibiotic or corticosteroid within 5 days) exacerbations. The cohort was split into training (75%) and validation (25%) sets. Within the training cohort, stepwise logistic regression models were created to evaluate risk of exacerbations based on factors measured during the baseline period. Models were evaluated using sensitivity, specificity, and positive and negative predictive values. The base model included all confounding or effect modifier covariates. Several other models were explored using different sets of observations and variables to determine the best predictive model. RESULTS: There were 478,772 patients included in the analytic sample, of which 40.5% had exacerbations during the outcome period. Patients with exacerbations had slightly more comorbidities, medication use, and health care resource utilization compared with patients without exacerbations. In the base model, sensitivity was 41.6% and specificity was 85.5%. Positive and negative predictive values were 66.2% and 68.2%, respectively. Other models that were evaluated resulted in similar test characteristics as the base model. CONCLUSIONS: In this study, we were not able to predict COPD exacerbations with a high level of accuracy using health insurance claims data from COPD patients treated with bronchodilator-based combination therapy. Future studies should be done to explore predictive models for exacerbations.
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spelling pubmed-103981132023-08-04 Predicting Acute Exacerbations in Chronic Obstructive Pulmonary Disease Samp, Jennifer C. Joo, Min J. Schumock, Glen T. Calip, Gregory S. Pickard, A. Simon Lee, Todd A. J Manag Care Spec Pharm Research BACKGROUND: With increasing health care costs that have outpaced those of other industries, payers of health care are moving from a fee-for-service payment model to one in which reimbursement is tied to outcomes. Chronic obstructive pulmonary disease (COPD) is a disease where this payment model has been implemented by some payers, and COPD exacerbations are a quality metric that is used. Under an outcomes-based payment model, it is important for health systems to be able to identify patients at risk for poor outcomes so that they can target interventions to improve outcomes. OBJECTIVE: To develop and evaluate predictive models that could be used to identify patients at high risk for COPD exacerbations. METHODS: This study was retrospective and observational and included COPD patients treated with a bronchodilator-based combination therapy. We used health insurance claims data to obtain demographics, enrollment information, comorbidities, medication use, and health care resource utilization for each patient over a 6-month baseline period. Exacerbations were examined over a 6-month outcome period and included inpatient (primary discharge diagnosis for COPD), outpatient, and emergency department (outpatient/emergency department visits with a COPD diagnosis plus an acute prescription for an antibiotic or corticosteroid within 5 days) exacerbations. The cohort was split into training (75%) and validation (25%) sets. Within the training cohort, stepwise logistic regression models were created to evaluate risk of exacerbations based on factors measured during the baseline period. Models were evaluated using sensitivity, specificity, and positive and negative predictive values. The base model included all confounding or effect modifier covariates. Several other models were explored using different sets of observations and variables to determine the best predictive model. RESULTS: There were 478,772 patients included in the analytic sample, of which 40.5% had exacerbations during the outcome period. Patients with exacerbations had slightly more comorbidities, medication use, and health care resource utilization compared with patients without exacerbations. In the base model, sensitivity was 41.6% and specificity was 85.5%. Positive and negative predictive values were 66.2% and 68.2%, respectively. Other models that were evaluated resulted in similar test characteristics as the base model. CONCLUSIONS: In this study, we were not able to predict COPD exacerbations with a high level of accuracy using health insurance claims data from COPD patients treated with bronchodilator-based combination therapy. Future studies should be done to explore predictive models for exacerbations. Academy of Managed Care Pharmacy 2018-03 /pmc/articles/PMC10398113/ /pubmed/29485951 http://dx.doi.org/10.18553/jmcp.2018.24.3.265 Text en Copyright © 2018, Academy of Managed Care Pharmacy. All rights reserved. https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research
Samp, Jennifer C.
Joo, Min J.
Schumock, Glen T.
Calip, Gregory S.
Pickard, A. Simon
Lee, Todd A.
Predicting Acute Exacerbations in Chronic Obstructive Pulmonary Disease
title Predicting Acute Exacerbations in Chronic Obstructive Pulmonary Disease
title_full Predicting Acute Exacerbations in Chronic Obstructive Pulmonary Disease
title_fullStr Predicting Acute Exacerbations in Chronic Obstructive Pulmonary Disease
title_full_unstemmed Predicting Acute Exacerbations in Chronic Obstructive Pulmonary Disease
title_short Predicting Acute Exacerbations in Chronic Obstructive Pulmonary Disease
title_sort predicting acute exacerbations in chronic obstructive pulmonary disease
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398113/
https://www.ncbi.nlm.nih.gov/pubmed/29485951
http://dx.doi.org/10.18553/jmcp.2018.24.3.265
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