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Disturbed lipid profile in common variable immunodeficiency – a pathogenic loop of inflammation and metabolic disturbances
The relationship between metabolic and inflammatory pathways play a pathogenic role in various cardiometabolic disorders and is potentially also involved in the pathogenesis of other disorders such as cancer, autoimmunity and infectious diseases. Common variable immunodeficiency (CVID) is the most c...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398391/ https://www.ncbi.nlm.nih.gov/pubmed/37545531 http://dx.doi.org/10.3389/fimmu.2023.1199727 |
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author | Jorgensen, Silje F. Macpherson, Magnhild E. Skarpengland, Tonje Berge, Rolf K. Fevang, Børre Halvorsen, Bente Aukrust, Pål |
author_facet | Jorgensen, Silje F. Macpherson, Magnhild E. Skarpengland, Tonje Berge, Rolf K. Fevang, Børre Halvorsen, Bente Aukrust, Pål |
author_sort | Jorgensen, Silje F. |
collection | PubMed |
description | The relationship between metabolic and inflammatory pathways play a pathogenic role in various cardiometabolic disorders and is potentially also involved in the pathogenesis of other disorders such as cancer, autoimmunity and infectious diseases. Common variable immunodeficiency (CVID) is the most common primary immunodeficiency in adults, characterized by increased frequency of airway infections with capsulated bacteria. In addition, a large proportion of CVID patients have autoimmune and inflammatory complications associated with systemic inflammation. We summarize the evidence that support a role of a bidirectional pathogenic interaction between inflammation and metabolic disturbances in CVID. This include low levels and function of high-density lipoprotein (HDL), high levels of triglycerides (TG) and its major lipoprotein very low-density lipoprotein (VLDL), and an unfavorable fatty acid (FA) profile. The dysregulation of TG, VLDL and FA were linked to disturbed gut microbiota profile, and TG and VLDL levels were strongly associated with lipopolysaccharides (LPS), a marker of gut leakage in blood. Of note, the disturbed lipid profile in CVID did not include total cholesterol levels or high low-density lipoprotein levels. Furthermore, increased VLDL and TG levels in blood were not associated with diet, high body mass index and liver steatosis, suggesting a different phenotype than in patients with traditional cardiovascular risk such as metabolic syndrome. We hypothesize that these metabolic disturbances are linked to inflammation in a bidirectional manner with disturbed gut microbiota as a potential contributing factor. |
format | Online Article Text |
id | pubmed-10398391 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103983912023-08-04 Disturbed lipid profile in common variable immunodeficiency – a pathogenic loop of inflammation and metabolic disturbances Jorgensen, Silje F. Macpherson, Magnhild E. Skarpengland, Tonje Berge, Rolf K. Fevang, Børre Halvorsen, Bente Aukrust, Pål Front Immunol Immunology The relationship between metabolic and inflammatory pathways play a pathogenic role in various cardiometabolic disorders and is potentially also involved in the pathogenesis of other disorders such as cancer, autoimmunity and infectious diseases. Common variable immunodeficiency (CVID) is the most common primary immunodeficiency in adults, characterized by increased frequency of airway infections with capsulated bacteria. In addition, a large proportion of CVID patients have autoimmune and inflammatory complications associated with systemic inflammation. We summarize the evidence that support a role of a bidirectional pathogenic interaction between inflammation and metabolic disturbances in CVID. This include low levels and function of high-density lipoprotein (HDL), high levels of triglycerides (TG) and its major lipoprotein very low-density lipoprotein (VLDL), and an unfavorable fatty acid (FA) profile. The dysregulation of TG, VLDL and FA were linked to disturbed gut microbiota profile, and TG and VLDL levels were strongly associated with lipopolysaccharides (LPS), a marker of gut leakage in blood. Of note, the disturbed lipid profile in CVID did not include total cholesterol levels or high low-density lipoprotein levels. Furthermore, increased VLDL and TG levels in blood were not associated with diet, high body mass index and liver steatosis, suggesting a different phenotype than in patients with traditional cardiovascular risk such as metabolic syndrome. We hypothesize that these metabolic disturbances are linked to inflammation in a bidirectional manner with disturbed gut microbiota as a potential contributing factor. Frontiers Media S.A. 2023-07-20 /pmc/articles/PMC10398391/ /pubmed/37545531 http://dx.doi.org/10.3389/fimmu.2023.1199727 Text en Copyright © 2023 Jorgensen, Macpherson, Skarpengland, Berge, Fevang, Halvorsen and Aukrust https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Jorgensen, Silje F. Macpherson, Magnhild E. Skarpengland, Tonje Berge, Rolf K. Fevang, Børre Halvorsen, Bente Aukrust, Pål Disturbed lipid profile in common variable immunodeficiency – a pathogenic loop of inflammation and metabolic disturbances |
title | Disturbed lipid profile in common variable immunodeficiency – a pathogenic loop of inflammation and metabolic disturbances |
title_full | Disturbed lipid profile in common variable immunodeficiency – a pathogenic loop of inflammation and metabolic disturbances |
title_fullStr | Disturbed lipid profile in common variable immunodeficiency – a pathogenic loop of inflammation and metabolic disturbances |
title_full_unstemmed | Disturbed lipid profile in common variable immunodeficiency – a pathogenic loop of inflammation and metabolic disturbances |
title_short | Disturbed lipid profile in common variable immunodeficiency – a pathogenic loop of inflammation and metabolic disturbances |
title_sort | disturbed lipid profile in common variable immunodeficiency – a pathogenic loop of inflammation and metabolic disturbances |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398391/ https://www.ncbi.nlm.nih.gov/pubmed/37545531 http://dx.doi.org/10.3389/fimmu.2023.1199727 |
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