Clopidogrel-induced thrombotic thrombocytopenic purpura: a case report

Thrombotic thrombocytopenic purpura (TTP) is a rare variant of thrombotic microangiopathy. We report a case of TTP in a Nigerian chronic kidney disease (CKD) patient who was previously on clopidogrel. The features of TTP resolved soon after clopidogrel was withdrawn. Clopidogrel is a cardio-protecti...

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Autores principales: Ndulue, Chidozie N, Jisieike-Onuigbo, Nonyelum N, Okwesa, Nwabueze J, Anyanor, Arinze, Ozuemba, Bartholomew C, Osakwe, Nwamaka, Oguejiofor, Fidelis, Eze, Hyacinth, Kalu, Anya Ofia, Odenigbo, Charles U
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Makerere Medical School 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398446/
https://www.ncbi.nlm.nih.gov/pubmed/37545947
http://dx.doi.org/10.4314/ahs.v23i1.62
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author Ndulue, Chidozie N
Jisieike-Onuigbo, Nonyelum N
Okwesa, Nwabueze J
Anyanor, Arinze
Ozuemba, Bartholomew C
Osakwe, Nwamaka
Oguejiofor, Fidelis
Eze, Hyacinth
Kalu, Anya Ofia
Odenigbo, Charles U
author_facet Ndulue, Chidozie N
Jisieike-Onuigbo, Nonyelum N
Okwesa, Nwabueze J
Anyanor, Arinze
Ozuemba, Bartholomew C
Osakwe, Nwamaka
Oguejiofor, Fidelis
Eze, Hyacinth
Kalu, Anya Ofia
Odenigbo, Charles U
author_sort Ndulue, Chidozie N
collection PubMed
description Thrombotic thrombocytopenic purpura (TTP) is a rare variant of thrombotic microangiopathy. We report a case of TTP in a Nigerian chronic kidney disease (CKD) patient who was previously on clopidogrel. The features of TTP resolved soon after clopidogrel was withdrawn. Clopidogrel is a cardio-protective anti-platelet drug used in CKD patients at risk of dyspepsia. However, its potential to cause TTP should be recognized and considered in acute kidney injury (AKI) patients previously on clopidogrel.
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spelling pubmed-103984462023-08-04 Clopidogrel-induced thrombotic thrombocytopenic purpura: a case report Ndulue, Chidozie N Jisieike-Onuigbo, Nonyelum N Okwesa, Nwabueze J Anyanor, Arinze Ozuemba, Bartholomew C Osakwe, Nwamaka Oguejiofor, Fidelis Eze, Hyacinth Kalu, Anya Ofia Odenigbo, Charles U Afr Health Sci Articles Thrombotic thrombocytopenic purpura (TTP) is a rare variant of thrombotic microangiopathy. We report a case of TTP in a Nigerian chronic kidney disease (CKD) patient who was previously on clopidogrel. The features of TTP resolved soon after clopidogrel was withdrawn. Clopidogrel is a cardio-protective anti-platelet drug used in CKD patients at risk of dyspepsia. However, its potential to cause TTP should be recognized and considered in acute kidney injury (AKI) patients previously on clopidogrel. Makerere Medical School 2023-03 /pmc/articles/PMC10398446/ /pubmed/37545947 http://dx.doi.org/10.4314/ahs.v23i1.62 Text en © 2023 Ndulue CN et al. https://creativecommons.org/licenses/by/4.0/Licensee African Health Sciences. This is an Open Access article distributed under the terms of the Creative commons Attribution License (https://creativecommons.org/licenses/BY/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Ndulue, Chidozie N
Jisieike-Onuigbo, Nonyelum N
Okwesa, Nwabueze J
Anyanor, Arinze
Ozuemba, Bartholomew C
Osakwe, Nwamaka
Oguejiofor, Fidelis
Eze, Hyacinth
Kalu, Anya Ofia
Odenigbo, Charles U
Clopidogrel-induced thrombotic thrombocytopenic purpura: a case report
title Clopidogrel-induced thrombotic thrombocytopenic purpura: a case report
title_full Clopidogrel-induced thrombotic thrombocytopenic purpura: a case report
title_fullStr Clopidogrel-induced thrombotic thrombocytopenic purpura: a case report
title_full_unstemmed Clopidogrel-induced thrombotic thrombocytopenic purpura: a case report
title_short Clopidogrel-induced thrombotic thrombocytopenic purpura: a case report
title_sort clopidogrel-induced thrombotic thrombocytopenic purpura: a case report
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398446/
https://www.ncbi.nlm.nih.gov/pubmed/37545947
http://dx.doi.org/10.4314/ahs.v23i1.62
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