An evaluation of matrix metalloproteinase-9 (Mmp-9) and tissue inhibitor metalloproteinase-1 (Timp-1) Serum levels and the Mmp-9/Timp-1 Ratio in Covid-19 patients
BACKGROUND: The progression of COVID-19 has different clinical presentations, which raises a number of immunological questions. OBJECTIVES: This study aimed to investigate MMP-9 and TIMP-1 levels in patients diagnosed with COVID-19 and whether the MMP-9/TIMP-1 ratio is associated with lung involveme...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Makerere Medical School
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398462/ https://www.ncbi.nlm.nih.gov/pubmed/37545954 http://dx.doi.org/10.4314/ahs.v23i1.5 |
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author | Demir, Nazlim Aktug Kirik, Sema Yilmaz Sumer, Sua Ural, Onur Kiratlı, Hatice Esranur Vatansev, Husamettin Hayatsal, Esra Paydas Arslan, Ugur Cebeci, Hakan Demir, Lutfi Saltuk |
author_facet | Demir, Nazlim Aktug Kirik, Sema Yilmaz Sumer, Sua Ural, Onur Kiratlı, Hatice Esranur Vatansev, Husamettin Hayatsal, Esra Paydas Arslan, Ugur Cebeci, Hakan Demir, Lutfi Saltuk |
author_sort | Demir, Nazlim Aktug |
collection | PubMed |
description | BACKGROUND: The progression of COVID-19 has different clinical presentations, which raises a number of immunological questions. OBJECTIVES: This study aimed to investigate MMP-9 and TIMP-1 levels in patients diagnosed with COVID-19 and whether the MMP-9/TIMP-1 ratio is associated with lung involvement in COVID-19. METHODS: This study was conducted with 192 patients and 45 healthy controls. ELISA was used to measure the MMP-9 and TIMP-1. RESULTS: The MMP-9 and TIMP-1 levels of the patients were found to be higher than those of the controls. MMP-9 and TIMP-1 were detected more in patients with lung involvement on chest CT scans than in those with no lung involvement on chest CT scans. A comparison of lung involvement levels revealed no difference was found between the groups. The MMP-9/TIMP-1 ratio was 5.8 in the group with lung involvement on chest CT scans and 6.1 in the group without lung involvement on chest CT scans. No difference was found between the two groups. A comparison with respect to lung involvement levels showed that the MMP-9/TIMP-1 ratio difference was found between the groups. CONCLUSION: Diagnostic and treatment methods targeting MMP-9 activity or neutrophil activation may be important in predicting lung involvement in COVID-19 and directing clinical outcomes. |
format | Online Article Text |
id | pubmed-10398462 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Makerere Medical School |
record_format | MEDLINE/PubMed |
spelling | pubmed-103984622023-08-04 An evaluation of matrix metalloproteinase-9 (Mmp-9) and tissue inhibitor metalloproteinase-1 (Timp-1) Serum levels and the Mmp-9/Timp-1 Ratio in Covid-19 patients Demir, Nazlim Aktug Kirik, Sema Yilmaz Sumer, Sua Ural, Onur Kiratlı, Hatice Esranur Vatansev, Husamettin Hayatsal, Esra Paydas Arslan, Ugur Cebeci, Hakan Demir, Lutfi Saltuk Afr Health Sci Articles BACKGROUND: The progression of COVID-19 has different clinical presentations, which raises a number of immunological questions. OBJECTIVES: This study aimed to investigate MMP-9 and TIMP-1 levels in patients diagnosed with COVID-19 and whether the MMP-9/TIMP-1 ratio is associated with lung involvement in COVID-19. METHODS: This study was conducted with 192 patients and 45 healthy controls. ELISA was used to measure the MMP-9 and TIMP-1. RESULTS: The MMP-9 and TIMP-1 levels of the patients were found to be higher than those of the controls. MMP-9 and TIMP-1 were detected more in patients with lung involvement on chest CT scans than in those with no lung involvement on chest CT scans. A comparison of lung involvement levels revealed no difference was found between the groups. The MMP-9/TIMP-1 ratio was 5.8 in the group with lung involvement on chest CT scans and 6.1 in the group without lung involvement on chest CT scans. No difference was found between the two groups. A comparison with respect to lung involvement levels showed that the MMP-9/TIMP-1 ratio difference was found between the groups. CONCLUSION: Diagnostic and treatment methods targeting MMP-9 activity or neutrophil activation may be important in predicting lung involvement in COVID-19 and directing clinical outcomes. Makerere Medical School 2023-03 /pmc/articles/PMC10398462/ /pubmed/37545954 http://dx.doi.org/10.4314/ahs.v23i1.5 Text en © 2023 Demir NA et al. https://creativecommons.org/licenses/by/4.0/Licensee African Health Sciences. This is an Open Access article distributed under the terms of the Creative commons Attribution License (https://creativecommons.org/licenses/BY/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Demir, Nazlim Aktug Kirik, Sema Yilmaz Sumer, Sua Ural, Onur Kiratlı, Hatice Esranur Vatansev, Husamettin Hayatsal, Esra Paydas Arslan, Ugur Cebeci, Hakan Demir, Lutfi Saltuk An evaluation of matrix metalloproteinase-9 (Mmp-9) and tissue inhibitor metalloproteinase-1 (Timp-1) Serum levels and the Mmp-9/Timp-1 Ratio in Covid-19 patients |
title | An evaluation of matrix metalloproteinase-9 (Mmp-9) and tissue inhibitor metalloproteinase-1 (Timp-1) Serum levels and the Mmp-9/Timp-1 Ratio in Covid-19 patients |
title_full | An evaluation of matrix metalloproteinase-9 (Mmp-9) and tissue inhibitor metalloproteinase-1 (Timp-1) Serum levels and the Mmp-9/Timp-1 Ratio in Covid-19 patients |
title_fullStr | An evaluation of matrix metalloproteinase-9 (Mmp-9) and tissue inhibitor metalloproteinase-1 (Timp-1) Serum levels and the Mmp-9/Timp-1 Ratio in Covid-19 patients |
title_full_unstemmed | An evaluation of matrix metalloproteinase-9 (Mmp-9) and tissue inhibitor metalloproteinase-1 (Timp-1) Serum levels and the Mmp-9/Timp-1 Ratio in Covid-19 patients |
title_short | An evaluation of matrix metalloproteinase-9 (Mmp-9) and tissue inhibitor metalloproteinase-1 (Timp-1) Serum levels and the Mmp-9/Timp-1 Ratio in Covid-19 patients |
title_sort | evaluation of matrix metalloproteinase-9 (mmp-9) and tissue inhibitor metalloproteinase-1 (timp-1) serum levels and the mmp-9/timp-1 ratio in covid-19 patients |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398462/ https://www.ncbi.nlm.nih.gov/pubmed/37545954 http://dx.doi.org/10.4314/ahs.v23i1.5 |
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