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Case control study of CD4 cell count and some haematological parameters among hepatitis and non-hepatitis B patients in Oyo State, South-west, Nigeria
AIM: Hepatitis B virus HBV infection is a major cause of chronic liver disease worldwide. CD4 count and haematological parameters (HPs) could be used to monitor the health status of hepatitis B (HB) individuals. This study aimed at assessing levels of CD4 count and some HPs among sufferers of HB pat...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Makerere Medical School
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398485/ https://www.ncbi.nlm.nih.gov/pubmed/37545948 http://dx.doi.org/10.4314/ahs.v23i1.21 |
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author | Odusanya, Adebomi Funmilayo Makinde, Gabriel Ifeoluwa Idowu, Michael Oladimeji Adebayo, Ayodeji Matthew |
author_facet | Odusanya, Adebomi Funmilayo Makinde, Gabriel Ifeoluwa Idowu, Michael Oladimeji Adebayo, Ayodeji Matthew |
author_sort | Odusanya, Adebomi Funmilayo |
collection | PubMed |
description | AIM: Hepatitis B virus HBV infection is a major cause of chronic liver disease worldwide. CD4 count and haematological parameters (HPs) could be used to monitor the health status of hepatitis B (HB) individuals. This study aimed at assessing levels of CD4 count and some HPs among sufferers of HB patients and controls. METHODS: Fifty (50) HB patients as cases and 50 age-matched controls were recruited into the study. 5ml of whole blood sample was collected from all eligible participants of which 20µl and 10µl were used for CD4 count and HPs analysis respectively. Pearson correlation analysis was used to assess statistical difference within them using SPSS version 20. RESULTS: There was significant increase between the normal values of the CD4 count of both cases and controls (p<0.05). Significant correlations were found in some HPs such as HCT with WBC; HB and RBC with PLT; RBC, HCT and PLT with WBC. CONCLUSION: There were no significant differences between the values of the CD4 count and hematological parameters among HB subjects in this study. There is need for future studies to detect changes in CD4 count and other HPs in HB patients to increase options of screening for immunological changes during management. |
format | Online Article Text |
id | pubmed-10398485 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Makerere Medical School |
record_format | MEDLINE/PubMed |
spelling | pubmed-103984852023-08-04 Case control study of CD4 cell count and some haematological parameters among hepatitis and non-hepatitis B patients in Oyo State, South-west, Nigeria Odusanya, Adebomi Funmilayo Makinde, Gabriel Ifeoluwa Idowu, Michael Oladimeji Adebayo, Ayodeji Matthew Afr Health Sci Articles AIM: Hepatitis B virus HBV infection is a major cause of chronic liver disease worldwide. CD4 count and haematological parameters (HPs) could be used to monitor the health status of hepatitis B (HB) individuals. This study aimed at assessing levels of CD4 count and some HPs among sufferers of HB patients and controls. METHODS: Fifty (50) HB patients as cases and 50 age-matched controls were recruited into the study. 5ml of whole blood sample was collected from all eligible participants of which 20µl and 10µl were used for CD4 count and HPs analysis respectively. Pearson correlation analysis was used to assess statistical difference within them using SPSS version 20. RESULTS: There was significant increase between the normal values of the CD4 count of both cases and controls (p<0.05). Significant correlations were found in some HPs such as HCT with WBC; HB and RBC with PLT; RBC, HCT and PLT with WBC. CONCLUSION: There were no significant differences between the values of the CD4 count and hematological parameters among HB subjects in this study. There is need for future studies to detect changes in CD4 count and other HPs in HB patients to increase options of screening for immunological changes during management. Makerere Medical School 2023-03 /pmc/articles/PMC10398485/ /pubmed/37545948 http://dx.doi.org/10.4314/ahs.v23i1.21 Text en © 2023 Odusanya AF et al. https://creativecommons.org/licenses/by/4.0/Licensee African Health Sciences. This is an Open Access article distributed under the terms of the Creative commons Attribution License (https://creativecommons.org/licenses/BY/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Odusanya, Adebomi Funmilayo Makinde, Gabriel Ifeoluwa Idowu, Michael Oladimeji Adebayo, Ayodeji Matthew Case control study of CD4 cell count and some haematological parameters among hepatitis and non-hepatitis B patients in Oyo State, South-west, Nigeria |
title | Case control study of CD4 cell count and some haematological parameters among hepatitis and non-hepatitis B patients in Oyo State, South-west, Nigeria |
title_full | Case control study of CD4 cell count and some haematological parameters among hepatitis and non-hepatitis B patients in Oyo State, South-west, Nigeria |
title_fullStr | Case control study of CD4 cell count and some haematological parameters among hepatitis and non-hepatitis B patients in Oyo State, South-west, Nigeria |
title_full_unstemmed | Case control study of CD4 cell count and some haematological parameters among hepatitis and non-hepatitis B patients in Oyo State, South-west, Nigeria |
title_short | Case control study of CD4 cell count and some haematological parameters among hepatitis and non-hepatitis B patients in Oyo State, South-west, Nigeria |
title_sort | case control study of cd4 cell count and some haematological parameters among hepatitis and non-hepatitis b patients in oyo state, south-west, nigeria |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398485/ https://www.ncbi.nlm.nih.gov/pubmed/37545948 http://dx.doi.org/10.4314/ahs.v23i1.21 |
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