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C9orf72 protein quality control by UBR5‐mediated heterotypic ubiquitin chains

Hexanucleotide repeat expansions within C9orf72 are a frequent cause of amyotrophic lateral sclerosis and frontotemporal dementia. Haploinsufficiency leading to reduced C9orf72 protein contributes to disease pathogenesis. C9orf72 binds SMCR8 to form a robust complex that regulates small GTPases, lys...

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Detalles Bibliográficos
Autores principales:	Jülg, Julia, Edbauer, Dieter, Behrends, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398660/ https://www.ncbi.nlm.nih.gov/pubmed/37317656 http://dx.doi.org/10.15252/embr.202255895

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