Cargando…

Tracking of serum lipids in healthy children on a year-to-year basis

OBJECTIVES: To assess the stability of lipid profiles throughout childhood and evaluate their onset and dynamic. MATERIALS AND METHODS: Lipid markers were longitudinally measured in more than 1300 healthy children from the LIFE Child study (Germany) and categorized into normal, at-risk, or adverse....

Descripción completa

Detalles Bibliográficos
Autores principales: Maidowski, Ludwig, Kiess, Wieland, Baber, Ronny, Dathan-Stumpf, Anne, Ceglarek, Uta, Vogel, Mandy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398926/
https://www.ncbi.nlm.nih.gov/pubmed/37532994
http://dx.doi.org/10.1186/s12872-023-03391-9
_version_ 1785084136825815040
author Maidowski, Ludwig
Kiess, Wieland
Baber, Ronny
Dathan-Stumpf, Anne
Ceglarek, Uta
Vogel, Mandy
author_facet Maidowski, Ludwig
Kiess, Wieland
Baber, Ronny
Dathan-Stumpf, Anne
Ceglarek, Uta
Vogel, Mandy
author_sort Maidowski, Ludwig
collection PubMed
description OBJECTIVES: To assess the stability of lipid profiles throughout childhood and evaluate their onset and dynamic. MATERIALS AND METHODS: Lipid markers were longitudinally measured in more than 1300 healthy children from the LIFE Child study (Germany) and categorized into normal, at-risk, or adverse. Year-to-year intra-person persistence of the categories during follow-ups was examined and Pearson’s correlation coefficient was calculated. RESULTS: We found strong positive correlations for TC, LDL-C and ApoB (r > 0.75, p < 0.001) from the age of four years. Correlations were lowest during the first two years of life. Most children with normal levels also had normal levels the following year. Children with at-risk levels showed a tendency towards normal levels at the follow-up visit. Adverse levels of TC, LDL-C, ApoB (all ages), and HDL-C (from age 15) persisted in more than half of the affected children. Age-dependent patterns of stability were most pronounced and similar for TC, LDL-C, and ApoB. CONCLUSIONS: Normal levels of serum lipids show high stability and adverse levels stabilized in early childhood for TC, LDL, and ApoB. At-risk and adverse levels of TC, LDL-C or ApoB may warrant further or repeated diagnostic measurements with regards to preventing CVD in the long run. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12872-023-03391-9.
format Online
Article
Text
id pubmed-10398926
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-103989262023-08-04 Tracking of serum lipids in healthy children on a year-to-year basis Maidowski, Ludwig Kiess, Wieland Baber, Ronny Dathan-Stumpf, Anne Ceglarek, Uta Vogel, Mandy BMC Cardiovasc Disord Research OBJECTIVES: To assess the stability of lipid profiles throughout childhood and evaluate their onset and dynamic. MATERIALS AND METHODS: Lipid markers were longitudinally measured in more than 1300 healthy children from the LIFE Child study (Germany) and categorized into normal, at-risk, or adverse. Year-to-year intra-person persistence of the categories during follow-ups was examined and Pearson’s correlation coefficient was calculated. RESULTS: We found strong positive correlations for TC, LDL-C and ApoB (r > 0.75, p < 0.001) from the age of four years. Correlations were lowest during the first two years of life. Most children with normal levels also had normal levels the following year. Children with at-risk levels showed a tendency towards normal levels at the follow-up visit. Adverse levels of TC, LDL-C, ApoB (all ages), and HDL-C (from age 15) persisted in more than half of the affected children. Age-dependent patterns of stability were most pronounced and similar for TC, LDL-C, and ApoB. CONCLUSIONS: Normal levels of serum lipids show high stability and adverse levels stabilized in early childhood for TC, LDL, and ApoB. At-risk and adverse levels of TC, LDL-C or ApoB may warrant further or repeated diagnostic measurements with regards to preventing CVD in the long run. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12872-023-03391-9. BioMed Central 2023-08-02 /pmc/articles/PMC10398926/ /pubmed/37532994 http://dx.doi.org/10.1186/s12872-023-03391-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Maidowski, Ludwig
Kiess, Wieland
Baber, Ronny
Dathan-Stumpf, Anne
Ceglarek, Uta
Vogel, Mandy
Tracking of serum lipids in healthy children on a year-to-year basis
title Tracking of serum lipids in healthy children on a year-to-year basis
title_full Tracking of serum lipids in healthy children on a year-to-year basis
title_fullStr Tracking of serum lipids in healthy children on a year-to-year basis
title_full_unstemmed Tracking of serum lipids in healthy children on a year-to-year basis
title_short Tracking of serum lipids in healthy children on a year-to-year basis
title_sort tracking of serum lipids in healthy children on a year-to-year basis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398926/
https://www.ncbi.nlm.nih.gov/pubmed/37532994
http://dx.doi.org/10.1186/s12872-023-03391-9
work_keys_str_mv AT maidowskiludwig trackingofserumlipidsinhealthychildrenonayeartoyearbasis
AT kiesswieland trackingofserumlipidsinhealthychildrenonayeartoyearbasis
AT baberronny trackingofserumlipidsinhealthychildrenonayeartoyearbasis
AT dathanstumpfanne trackingofserumlipidsinhealthychildrenonayeartoyearbasis
AT ceglarekuta trackingofserumlipidsinhealthychildrenonayeartoyearbasis
AT vogelmandy trackingofserumlipidsinhealthychildrenonayeartoyearbasis