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Tracking of serum lipids in healthy children on a year-to-year basis
OBJECTIVES: To assess the stability of lipid profiles throughout childhood and evaluate their onset and dynamic. MATERIALS AND METHODS: Lipid markers were longitudinally measured in more than 1300 healthy children from the LIFE Child study (Germany) and categorized into normal, at-risk, or adverse....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398926/ https://www.ncbi.nlm.nih.gov/pubmed/37532994 http://dx.doi.org/10.1186/s12872-023-03391-9 |
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author | Maidowski, Ludwig Kiess, Wieland Baber, Ronny Dathan-Stumpf, Anne Ceglarek, Uta Vogel, Mandy |
author_facet | Maidowski, Ludwig Kiess, Wieland Baber, Ronny Dathan-Stumpf, Anne Ceglarek, Uta Vogel, Mandy |
author_sort | Maidowski, Ludwig |
collection | PubMed |
description | OBJECTIVES: To assess the stability of lipid profiles throughout childhood and evaluate their onset and dynamic. MATERIALS AND METHODS: Lipid markers were longitudinally measured in more than 1300 healthy children from the LIFE Child study (Germany) and categorized into normal, at-risk, or adverse. Year-to-year intra-person persistence of the categories during follow-ups was examined and Pearson’s correlation coefficient was calculated. RESULTS: We found strong positive correlations for TC, LDL-C and ApoB (r > 0.75, p < 0.001) from the age of four years. Correlations were lowest during the first two years of life. Most children with normal levels also had normal levels the following year. Children with at-risk levels showed a tendency towards normal levels at the follow-up visit. Adverse levels of TC, LDL-C, ApoB (all ages), and HDL-C (from age 15) persisted in more than half of the affected children. Age-dependent patterns of stability were most pronounced and similar for TC, LDL-C, and ApoB. CONCLUSIONS: Normal levels of serum lipids show high stability and adverse levels stabilized in early childhood for TC, LDL, and ApoB. At-risk and adverse levels of TC, LDL-C or ApoB may warrant further or repeated diagnostic measurements with regards to preventing CVD in the long run. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12872-023-03391-9. |
format | Online Article Text |
id | pubmed-10398926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-103989262023-08-04 Tracking of serum lipids in healthy children on a year-to-year basis Maidowski, Ludwig Kiess, Wieland Baber, Ronny Dathan-Stumpf, Anne Ceglarek, Uta Vogel, Mandy BMC Cardiovasc Disord Research OBJECTIVES: To assess the stability of lipid profiles throughout childhood and evaluate their onset and dynamic. MATERIALS AND METHODS: Lipid markers were longitudinally measured in more than 1300 healthy children from the LIFE Child study (Germany) and categorized into normal, at-risk, or adverse. Year-to-year intra-person persistence of the categories during follow-ups was examined and Pearson’s correlation coefficient was calculated. RESULTS: We found strong positive correlations for TC, LDL-C and ApoB (r > 0.75, p < 0.001) from the age of four years. Correlations were lowest during the first two years of life. Most children with normal levels also had normal levels the following year. Children with at-risk levels showed a tendency towards normal levels at the follow-up visit. Adverse levels of TC, LDL-C, ApoB (all ages), and HDL-C (from age 15) persisted in more than half of the affected children. Age-dependent patterns of stability were most pronounced and similar for TC, LDL-C, and ApoB. CONCLUSIONS: Normal levels of serum lipids show high stability and adverse levels stabilized in early childhood for TC, LDL, and ApoB. At-risk and adverse levels of TC, LDL-C or ApoB may warrant further or repeated diagnostic measurements with regards to preventing CVD in the long run. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12872-023-03391-9. BioMed Central 2023-08-02 /pmc/articles/PMC10398926/ /pubmed/37532994 http://dx.doi.org/10.1186/s12872-023-03391-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Maidowski, Ludwig Kiess, Wieland Baber, Ronny Dathan-Stumpf, Anne Ceglarek, Uta Vogel, Mandy Tracking of serum lipids in healthy children on a year-to-year basis |
title | Tracking of serum lipids in healthy children on a year-to-year basis |
title_full | Tracking of serum lipids in healthy children on a year-to-year basis |
title_fullStr | Tracking of serum lipids in healthy children on a year-to-year basis |
title_full_unstemmed | Tracking of serum lipids in healthy children on a year-to-year basis |
title_short | Tracking of serum lipids in healthy children on a year-to-year basis |
title_sort | tracking of serum lipids in healthy children on a year-to-year basis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398926/ https://www.ncbi.nlm.nih.gov/pubmed/37532994 http://dx.doi.org/10.1186/s12872-023-03391-9 |
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