Cargando…

Prmt5 deficiency inhibits CD4+ T-cell Klf2/S1pr1 expression and ameliorates EAE disease

BACKGROUND: Protein arginine methyltransferase 5 (Prmt5) is the main type II methyltransferase, catalyzes protein arginine residue symmetric dimethylation, and modulates normal cellular physiology and disease progression. Prmt5 inhibition or deletion in CD4+ T cells has been reported to ameliorate e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Yingxia, Chen, Zheyi, Zhou, Bingqian, Chen, Shiyu, Chen, Ningdai, Shen, Lisong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398933/ https://www.ncbi.nlm.nih.gov/pubmed/37533053 http://dx.doi.org/10.1186/s12974-023-02854-2

Ejemplares similares

PRMT5 Inhibition Promotes PD-L1 Expression and Immuno-Resistance in Lung Cancer
por: Hu, Rui, et al.
Publicado: (2022)

Interleukin 32 Promotes Foxp3(+) Treg Cell Development and CD8(+) T Cell Function in Human Esophageal Squamous Cell Carcinoma Microenvironment
por: Han, Li, et al.
Publicado: (2021)

PD-L1(+)CD8(+) T cells enrichment in lung cancer exerted regulatory function and tumor-promoting tolerance
por: Zheng, Yingxia, et al.
Publicado: (2022)

Klf4 methylated by Prmt1 restrains the commitment of primitive endoderm
por: Zuo, Zhen-yu, et al.
Publicado: (2022)

PRMT5 Promotes Cyclin E1 and Cell Cycle Progression in CD4 Th1 Cells and Correlates With EAE Severity
por: Amici, Stephanie A., et al.
Publicado: (2021)

PRMT1 loss sensitizes cells to PRMT5 inhibition
por: Gao, Guozhen, et al.
Publicado: (2019)

Oleanolic acid ameliorates intestinal alterations associated with EAE
por: Gutierrez, Beatriz, et al.
Publicado: (2020)

A novel small-molecule antagonizes PRMT5-mediated KLF4 methylation for targeted therapy
por: Zhou, Zhuan, et al.
Publicado: (2019)

Pro-inflammatory Effect of Downregulated CD73 Expression in EAE Astrocytes
por: Zhou, Shumin, et al.
Publicado: (2019)

MicroRNA-7 Deficiency Ameliorates the Pathologies of Acute Lung Injury through Elevating KLF4
por: Zhao, Juanjuan, et al.
Publicado: (2016)

Protein arginine methyltransferases PRMT1, PRMT4/CARM1 and PRMT5 have distinct functions in control of osteoblast differentiation
por: Dashti, Parisa, et al.
Publicado: (2023)

Knockout of KLF10 Ameliorated Diabetic Renal Fibrosis via Downregulation of DKK-1
por: Hsu, Yung-Chien, et al.
Publicado: (2022)

Immune suppressive landscape in the human esophageal squamous cell carcinoma microenvironment
por: Zheng, Yingxia, et al.
Publicado: (2020)

Hepatic PRMT1 ameliorates diet-induced hepatic steatosis via induction of PGC1α
por: Xu, Lu, et al.
Publicado: (2022)

CD19(+)CD24(hi)CD38(hi)Bregs involved in downregulate helper T cells and upregulate regulatory T cells in gastric cancer
por: Wang, Weiwei, et al.
Publicado: (2015)

CD226 Attenuates Treg Proliferation via Akt and Erk Signaling in an EAE Model
por: Wang, Ning, et al.
Publicado: (2020)

Differential effects of SARM1 inhibition in traumatic glaucoma and EAE optic neuropathies
por: Liu, Pingting, et al.
Publicado: (2023)

Alterations in CD200-CD200R1 System during EAE Already Manifest at Presymptomatic Stages
por: Valente, Tony, et al.
Publicado: (2017)

CSF1R Stimulation Promotes Increased Neuroprotection by CD11c+ Microglia in EAE
por: Wlodarczyk, Agnieszka, et al.
Publicado: (2019)

The Methyltransferases PRMT4/CARM1 and PRMT5 Control Differentially Myogenesis in Zebrafish
por: Batut, Julie, et al.
Publicado: (2011)

5-HMF attenuates inflammation and demyelination in experimental autoimmune encephalomyelitis mice by inhibiting the MIF-CD74 interaction: Role of 5-HMF in EAE mice
por: Guan, Dongsheng, et al.
Publicado: (2023)

Transmembrane protein CD69 acts as an S1PR1 agonist
por: Chen, Hongwen, et al.
Publicado: (2023)

Transmembrane protein CD69 acts as an S1PR1 agonist
por: Chen, Hongwen, et al.
Publicado: (2023)

Prmt1 upregulated by Hdc deficiency aggravates acute myocardial infarction via NETosis
por: Zhang, Zhiwei, et al.
Publicado: (2022)

PRMT5 regulates ovarian follicle development by facilitating Wt1 translation
por: Chen, Min, et al.
Publicado: (2021)

NFIL3 deficiency alleviates EAE through regulating different immune cell subsets
por: Chen, Zhigang, et al.
Publicado: (2021)

Structure, Activity, and Function of PRMT1
por: Thiebaut, Charlène, et al.
Publicado: (2021)

A feedback loop comprising PRMT7 and miR-24-2 interplays with Oct4, Nanog, Klf4 and c-Myc to regulate stemness
por: Lee, Sung-Hun, et al.
Publicado: (2016)

Induction of NTPDase1/CD39 by Reactive Microglia and Macrophages Is Associated With the Functional State During EAE
por: Jakovljevic, Marija, et al.
Publicado: (2019)

Epigallocatechin-3-gallate ameliorates erectile function in aged rats via regulation of PRMT1/DDAH/ADMA/NOS metabolism pathway
por: Chen, Dong, et al.
Publicado: (2017)

Rethinking EAE pathogenesis
por: Van Epps, Heather L.
Publicado: (2005)

PARing down EAE
por: Van Epps, Heather L.
Publicado: (2006)

PRMT1 inhibition induces differentiation of colon cancer cells
por: Plotnikov, Alexander, et al.
Publicado: (2020)

NAD(+) protects against EAE by regulating CD4(+) T-cell differentiation
por: Tullius, Stefan G., et al.
Publicado: (2014)

Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4)
por: Gunnell, Emma A., et al.
Publicado: (2020)

KLF5 inhibition potentiates anti-PD1 efficacy by enhancing CD8(+) T-cell-dependent antitumor immunity
por: Wu, Qi, et al.
Publicado: (2023)

PRMT5 disruption drives antitumor immunity in cervical cancer by reprogramming T cell-mediated response and regulating PD-L1 expression
por: Jiang, Yongshuai, et al.
Publicado: (2021)

TNFR1 inhibition with a Nanobody protects against EAE development in mice
por: Steeland, Sophie, et al.
Publicado: (2017)

Knockdown of KLF5 ameliorates renal fibrosis in MRL/lpr mice via inhibition of MX1 transcription
por: Tao, Shanshan, et al.
Publicado: (2023)

CD226 ligation protects against EAE by promoting IL-10 expression via regulation of CD4(+) T cell differentiation
por: Zhang, Rong, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_2svd91hi7emf771bmabdh881bi