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Prognostic value of triglyceride glucose index in population at high cardiovascular disease risk

BACKGROUND: Early identification of populations at high cardiovascular disease (CVD) risk and improvement of risk factors can significantly decrease the probability of CVD development and improve outcomes. Insulin resistance (IR) is a CVD risk factor. The triglyceride glucose (TyG) index is a simple...

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Autores principales: Cai, Xiao-ling, Xiang, Yi-fei, Chen, Xiao-fang, Lin, Xue-qin, Lin, Bi-ting, Zhou, Geng-yu, Yu, Lin, Guo, Yan-song, Lin, Kai-yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398968/
https://www.ncbi.nlm.nih.gov/pubmed/37537553
http://dx.doi.org/10.1186/s12933-023-01924-2
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author Cai, Xiao-ling
Xiang, Yi-fei
Chen, Xiao-fang
Lin, Xue-qin
Lin, Bi-ting
Zhou, Geng-yu
Yu, Lin
Guo, Yan-song
Lin, Kai-yang
author_facet Cai, Xiao-ling
Xiang, Yi-fei
Chen, Xiao-fang
Lin, Xue-qin
Lin, Bi-ting
Zhou, Geng-yu
Yu, Lin
Guo, Yan-song
Lin, Kai-yang
author_sort Cai, Xiao-ling
collection PubMed
description BACKGROUND: Early identification of populations at high cardiovascular disease (CVD) risk and improvement of risk factors can significantly decrease the probability of CVD development and improve outcomes. Insulin resistance (IR) is a CVD risk factor. The triglyceride glucose (TyG) index is a simple and reliable index for evaluating IR. However, no clinical studies on the prognostic value of the TyG index in a high risk CVD population have been conducted. This study evaluated the relationship between the TyG index and prognosis in a high risk CVD population. METHODS: This study enrolled 35,455 participants aged 35–75 years who were at high CVD risk and visited selected health centers and community service centers between 2017 and 2021. Their general clinical characteristics and baseline blood biochemical indicators were recorded. The TyG index was calculated as ln[fasting triglyceride (mg/dl)× fasting blood glucose (mg/dl)/2]. The endpoints were all-cause death and cardiovascular death during follow-up. Cox proportional hazard models and restricted cubic spline (RCS) analysis were used to evaluate the correlation between the TyG index and endpoints. RESULTS: In the overall study population, the mean age of all participants was 57.9 ± 9.6 years, 40.7% were male, and the mean TyG index was 8.9 ± 0.6. All participants were divided into two groups based on the results of the RCS analysis, with a cut-off value of 9.83. There were 551 all-cause deaths and 180 cardiovascular deaths during a median follow-up time of 3.4 years. In the multivariate Cox proportional hazard model, participants with a TyG index ≥ 9.83 had a higher risk of all-cause death (Hazard ratio [HR] 1.86, 95% Confdence intervals [CI] 1.37–2.51, P<0.001) and cardiovascular death (HR 2.41, 95%CI 1.47–3.96, P = 0.001) than those with a TyG index < 9.83. Subgroup analysis revealed that there was no interaction between the TyG index and variables in all subgroup analyses. CONCLUSIONS: The high TyG index was associated with an increased risk of all-cause death and cardiovascular death in people at high risk of CVD. This finding demonstrates the value of the TyG index in the primary prevention of CVD. TRIAL REGISTRATION: retrospectively registered, the registration number is K2022-01-005 and the date is 2022.01.30.
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spelling pubmed-103989682023-08-04 Prognostic value of triglyceride glucose index in population at high cardiovascular disease risk Cai, Xiao-ling Xiang, Yi-fei Chen, Xiao-fang Lin, Xue-qin Lin, Bi-ting Zhou, Geng-yu Yu, Lin Guo, Yan-song Lin, Kai-yang Cardiovasc Diabetol Research BACKGROUND: Early identification of populations at high cardiovascular disease (CVD) risk and improvement of risk factors can significantly decrease the probability of CVD development and improve outcomes. Insulin resistance (IR) is a CVD risk factor. The triglyceride glucose (TyG) index is a simple and reliable index for evaluating IR. However, no clinical studies on the prognostic value of the TyG index in a high risk CVD population have been conducted. This study evaluated the relationship between the TyG index and prognosis in a high risk CVD population. METHODS: This study enrolled 35,455 participants aged 35–75 years who were at high CVD risk and visited selected health centers and community service centers between 2017 and 2021. Their general clinical characteristics and baseline blood biochemical indicators were recorded. The TyG index was calculated as ln[fasting triglyceride (mg/dl)× fasting blood glucose (mg/dl)/2]. The endpoints were all-cause death and cardiovascular death during follow-up. Cox proportional hazard models and restricted cubic spline (RCS) analysis were used to evaluate the correlation between the TyG index and endpoints. RESULTS: In the overall study population, the mean age of all participants was 57.9 ± 9.6 years, 40.7% were male, and the mean TyG index was 8.9 ± 0.6. All participants were divided into two groups based on the results of the RCS analysis, with a cut-off value of 9.83. There were 551 all-cause deaths and 180 cardiovascular deaths during a median follow-up time of 3.4 years. In the multivariate Cox proportional hazard model, participants with a TyG index ≥ 9.83 had a higher risk of all-cause death (Hazard ratio [HR] 1.86, 95% Confdence intervals [CI] 1.37–2.51, P<0.001) and cardiovascular death (HR 2.41, 95%CI 1.47–3.96, P = 0.001) than those with a TyG index < 9.83. Subgroup analysis revealed that there was no interaction between the TyG index and variables in all subgroup analyses. CONCLUSIONS: The high TyG index was associated with an increased risk of all-cause death and cardiovascular death in people at high risk of CVD. This finding demonstrates the value of the TyG index in the primary prevention of CVD. TRIAL REGISTRATION: retrospectively registered, the registration number is K2022-01-005 and the date is 2022.01.30. BioMed Central 2023-08-03 /pmc/articles/PMC10398968/ /pubmed/37537553 http://dx.doi.org/10.1186/s12933-023-01924-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Cai, Xiao-ling
Xiang, Yi-fei
Chen, Xiao-fang
Lin, Xue-qin
Lin, Bi-ting
Zhou, Geng-yu
Yu, Lin
Guo, Yan-song
Lin, Kai-yang
Prognostic value of triglyceride glucose index in population at high cardiovascular disease risk
title Prognostic value of triglyceride glucose index in population at high cardiovascular disease risk
title_full Prognostic value of triglyceride glucose index in population at high cardiovascular disease risk
title_fullStr Prognostic value of triglyceride glucose index in population at high cardiovascular disease risk
title_full_unstemmed Prognostic value of triglyceride glucose index in population at high cardiovascular disease risk
title_short Prognostic value of triglyceride glucose index in population at high cardiovascular disease risk
title_sort prognostic value of triglyceride glucose index in population at high cardiovascular disease risk
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398968/
https://www.ncbi.nlm.nih.gov/pubmed/37537553
http://dx.doi.org/10.1186/s12933-023-01924-2
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