Enhancer RNAs: mechanisms in transcriptional regulation and functions in diseases

In recent years, increasingly more non-coding RNAs have been detected with the development of high-throughput sequencing technology, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), small nucleolar RNAs (snoRNAs), and piwi-interacting RNA (piRNAs). The discover...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Qianhui, Liu, Xin, Wen, Jingtao, Chen, Xi, Xie, Bumin, Zhao, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398997/
https://www.ncbi.nlm.nih.gov/pubmed/37537618
http://dx.doi.org/10.1186/s12964-023-01206-0
_version_ 1785084156662775808
author Li, Qianhui
Liu, Xin
Wen, Jingtao
Chen, Xi
Xie, Bumin
Zhao, Yang
author_facet Li, Qianhui
Liu, Xin
Wen, Jingtao
Chen, Xi
Xie, Bumin
Zhao, Yang
author_sort Li, Qianhui
collection PubMed
description In recent years, increasingly more non-coding RNAs have been detected with the development of high-throughput sequencing technology, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), small nucleolar RNAs (snoRNAs), and piwi-interacting RNA (piRNAs). The discovery of enhancer RNAs (eRNAs) in 2010 has further broadened the range of non-coding RNAs revealed. eRNAs are non-coding RNA molecules produced by the transcription of DNA cis-acting elements, enhancer fragments. Recent studies revealed that the transcription of eRNAs may be a biological marker responding to enhancer activity that can participate in the regulation of coding gene transcription. In this review, we discussed the biological characteristics of eRNAs, their functions in transcriptional regulation, the regulation factors of eRNAs production, and the research progress of eRNAs in different diseases. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01206-0.
format Online
Article
Text
id pubmed-10398997
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-103989972023-08-04 Enhancer RNAs: mechanisms in transcriptional regulation and functions in diseases Li, Qianhui Liu, Xin Wen, Jingtao Chen, Xi Xie, Bumin Zhao, Yang Cell Commun Signal Review In recent years, increasingly more non-coding RNAs have been detected with the development of high-throughput sequencing technology, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), small nucleolar RNAs (snoRNAs), and piwi-interacting RNA (piRNAs). The discovery of enhancer RNAs (eRNAs) in 2010 has further broadened the range of non-coding RNAs revealed. eRNAs are non-coding RNA molecules produced by the transcription of DNA cis-acting elements, enhancer fragments. Recent studies revealed that the transcription of eRNAs may be a biological marker responding to enhancer activity that can participate in the regulation of coding gene transcription. In this review, we discussed the biological characteristics of eRNAs, their functions in transcriptional regulation, the regulation factors of eRNAs production, and the research progress of eRNAs in different diseases. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01206-0. BioMed Central 2023-08-03 /pmc/articles/PMC10398997/ /pubmed/37537618 http://dx.doi.org/10.1186/s12964-023-01206-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Li, Qianhui
Liu, Xin
Wen, Jingtao
Chen, Xi
Xie, Bumin
Zhao, Yang
Enhancer RNAs: mechanisms in transcriptional regulation and functions in diseases
title Enhancer RNAs: mechanisms in transcriptional regulation and functions in diseases
title_full Enhancer RNAs: mechanisms in transcriptional regulation and functions in diseases
title_fullStr Enhancer RNAs: mechanisms in transcriptional regulation and functions in diseases
title_full_unstemmed Enhancer RNAs: mechanisms in transcriptional regulation and functions in diseases
title_short Enhancer RNAs: mechanisms in transcriptional regulation and functions in diseases
title_sort enhancer rnas: mechanisms in transcriptional regulation and functions in diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398997/
https://www.ncbi.nlm.nih.gov/pubmed/37537618
http://dx.doi.org/10.1186/s12964-023-01206-0
work_keys_str_mv AT liqianhui enhancerrnasmechanismsintranscriptionalregulationandfunctionsindiseases
AT liuxin enhancerrnasmechanismsintranscriptionalregulationandfunctionsindiseases
AT wenjingtao enhancerrnasmechanismsintranscriptionalregulationandfunctionsindiseases
AT chenxi enhancerrnasmechanismsintranscriptionalregulationandfunctionsindiseases
AT xiebumin enhancerrnasmechanismsintranscriptionalregulationandfunctionsindiseases
AT zhaoyang enhancerrnasmechanismsintranscriptionalregulationandfunctionsindiseases

Ejemplares similares