First Total Synthesis of Tanzawaic Acid B

[Image: see text] The first total synthesis of (+)-tanzawaic acid B, a natural polyketide bearing a pentadienoic ester and octalin moiety, has been accomplished. The synthetic improvement from previous synthetic conditions facilitated our gram-scale synthesis of the chiral octalin that possesses sev...

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Detalles Bibliográficos
Autores principales: Murata, Takatsugu, Tsutsui, Hisazumi, Yoshida, Takumi, Kubota, Hirokazu, Hiraishi, Shintaro, Natsukawa, Hiyo, Suzuki, Yuki, Hiraga, Daiki, Mori, Takahiro, Maekawa, Yutaro, Tateyama, Satoru, Toyoyama, Kiyotaka, Ito, Keiichi, Suzuki, Kyohei, Yonekura, Keita, Shibata, Natsumi, Sato, Teruyuki, Tasaki, Yasutaka, Inohana, Takehiko, Takano, Atsuhiro, Egashira, Naoki, Honda, Masaki, Umezaki, Yuma, Shiina, Isamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399178/
https://www.ncbi.nlm.nih.gov/pubmed/37546667
http://dx.doi.org/10.1021/acsomega.3c03634
Descripción
Sumario:[Image: see text] The first total synthesis of (+)-tanzawaic acid B, a natural polyketide bearing a pentadienoic ester and octalin moiety, has been accomplished. The synthetic improvement from previous synthetic conditions facilitated our gram-scale synthesis of the chiral octalin that possesses seven stereogenic centers and that is the core skeleton of almost all of the tanzawaic acid family.

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