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First Total Synthesis of Tanzawaic Acid B
[Image: see text] The first total synthesis of (+)-tanzawaic acid B, a natural polyketide bearing a pentadienoic ester and octalin moiety, has been accomplished. The synthetic improvement from previous synthetic conditions facilitated our gram-scale synthesis of the chiral octalin that possesses sev...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399178/ https://www.ncbi.nlm.nih.gov/pubmed/37546667 http://dx.doi.org/10.1021/acsomega.3c03634 |
| _version_ | 1785084213999960064 |
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| author | Murata, Takatsugu Tsutsui, Hisazumi Yoshida, Takumi Kubota, Hirokazu Hiraishi, Shintaro Natsukawa, Hiyo Suzuki, Yuki Hiraga, Daiki Mori, Takahiro Maekawa, Yutaro Tateyama, Satoru Toyoyama, Kiyotaka Ito, Keiichi Suzuki, Kyohei Yonekura, Keita Shibata, Natsumi Sato, Teruyuki Tasaki, Yasutaka Inohana, Takehiko Takano, Atsuhiro Egashira, Naoki Honda, Masaki Umezaki, Yuma Shiina, Isamu |
| author_facet | Murata, Takatsugu Tsutsui, Hisazumi Yoshida, Takumi Kubota, Hirokazu Hiraishi, Shintaro Natsukawa, Hiyo Suzuki, Yuki Hiraga, Daiki Mori, Takahiro Maekawa, Yutaro Tateyama, Satoru Toyoyama, Kiyotaka Ito, Keiichi Suzuki, Kyohei Yonekura, Keita Shibata, Natsumi Sato, Teruyuki Tasaki, Yasutaka Inohana, Takehiko Takano, Atsuhiro Egashira, Naoki Honda, Masaki Umezaki, Yuma Shiina, Isamu |
| author_sort | Murata, Takatsugu |
| collection | PubMed |
| description | [Image: see text] The first total synthesis of (+)-tanzawaic acid B, a natural polyketide bearing a pentadienoic ester and octalin moiety, has been accomplished. The synthetic improvement from previous synthetic conditions facilitated our gram-scale synthesis of the chiral octalin that possesses seven stereogenic centers and that is the core skeleton of almost all of the tanzawaic acid family. |
| format | Online Article Text |
| id | pubmed-10399178 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | American Chemical Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-103991782023-08-04 First Total Synthesis of Tanzawaic Acid B Murata, Takatsugu Tsutsui, Hisazumi Yoshida, Takumi Kubota, Hirokazu Hiraishi, Shintaro Natsukawa, Hiyo Suzuki, Yuki Hiraga, Daiki Mori, Takahiro Maekawa, Yutaro Tateyama, Satoru Toyoyama, Kiyotaka Ito, Keiichi Suzuki, Kyohei Yonekura, Keita Shibata, Natsumi Sato, Teruyuki Tasaki, Yasutaka Inohana, Takehiko Takano, Atsuhiro Egashira, Naoki Honda, Masaki Umezaki, Yuma Shiina, Isamu ACS Omega [Image: see text] The first total synthesis of (+)-tanzawaic acid B, a natural polyketide bearing a pentadienoic ester and octalin moiety, has been accomplished. The synthetic improvement from previous synthetic conditions facilitated our gram-scale synthesis of the chiral octalin that possesses seven stereogenic centers and that is the core skeleton of almost all of the tanzawaic acid family. American Chemical Society 2023-07-19 /pmc/articles/PMC10399178/ /pubmed/37546667 http://dx.doi.org/10.1021/acsomega.3c03634 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Murata, Takatsugu Tsutsui, Hisazumi Yoshida, Takumi Kubota, Hirokazu Hiraishi, Shintaro Natsukawa, Hiyo Suzuki, Yuki Hiraga, Daiki Mori, Takahiro Maekawa, Yutaro Tateyama, Satoru Toyoyama, Kiyotaka Ito, Keiichi Suzuki, Kyohei Yonekura, Keita Shibata, Natsumi Sato, Teruyuki Tasaki, Yasutaka Inohana, Takehiko Takano, Atsuhiro Egashira, Naoki Honda, Masaki Umezaki, Yuma Shiina, Isamu First Total Synthesis of Tanzawaic Acid B |
| title | First Total Synthesis
of Tanzawaic Acid B |
| title_full | First Total Synthesis
of Tanzawaic Acid B |
| title_fullStr | First Total Synthesis
of Tanzawaic Acid B |
| title_full_unstemmed | First Total Synthesis
of Tanzawaic Acid B |
| title_short | First Total Synthesis
of Tanzawaic Acid B |
| title_sort | first total synthesis
of tanzawaic acid b |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399178/ https://www.ncbi.nlm.nih.gov/pubmed/37546667 http://dx.doi.org/10.1021/acsomega.3c03634 |
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