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FRS2-independent GRB2 interaction with FGFR2 is not required for embryonic development
FGF activation is known to engage canonical signals, including ERK/MAPK and PI3K/AKT, through various effectors including FRS2 and GRB2. Fgfr2(FCPG/FCPG) mutants that abrogate canonical intracellular signaling exhibit a range of mild phenotypes but are viable, in contrast to embryonic lethal Fgfr2(−...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists Ltd
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399203/ https://www.ncbi.nlm.nih.gov/pubmed/37421147 http://dx.doi.org/10.1242/bio.059942 |