The critical role of Rap1-GAPs Rasa3 and Sipa1 in T cells for pulmonary transit and egress from the lymph nodes

Rap1-GTPase activates integrins and plays an indispensable role in lymphocyte trafficking, but the importance of Rap1 inactivation in this process remains unknown. Here we identified the Rap1-inactivating proteins Rasa3 and Sipa1 as critical regulators of lymphocyte trafficking. The loss of Rasa3 an...

Descripción completa

Detalles Bibliográficos
Autores principales: Horitani, Shunsuke, Ueda, Yoshihiro, Kamioka, Yuji, Kondo, Naoyuki, Ikeda, Yoshiki, Naganuma, Makoto, Kinashi, Tatsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399222/
https://www.ncbi.nlm.nih.gov/pubmed/37545505
http://dx.doi.org/10.3389/fimmu.2023.1234747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399222/
https://www.ncbi.nlm.nih.gov/pubmed/37545505
http://dx.doi.org/10.3389/fimmu.2023.1234747

Ejemplares similares