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Integrating In Vitro Data and Physiologically Based Kinetic Modeling to Predict and Compare Acute Neurotoxic Doses of Saxitoxin in Rats, Mice, and Humans

[Image: see text] Current climate trends are likely to expand the geographic distribution of the toxigenic microalgae and concomitant phycotoxins, making intoxications by such toxins a global phenomenon. Among various phycotoxins, saxitoxin (STX) acts as a neurotoxin that might cause severe neurolog...

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Detalles Bibliográficos
Autores principales:	Chen, Jiaqi, Noorlander, Annelies, Wesseling, Sebastiaan, Bouwmeester, Hans, Kramer, Nynke I., Rietjens, Ivonne M.C.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399293/ https://www.ncbi.nlm.nih.gov/pubmed/37478462 http://dx.doi.org/10.1021/acs.est.3c01987

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