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Human papillomavirus vaccine effectiveness by age at vaccination: A systematic review
Human papillomavirus (HPV) vaccines work by preventing infections prior to natural exposure. Thus, it is likely more effective at younger ages, and it is important to understand how effectiveness might be diminished when administered at older ages. We conducted a systematic review of HPV vaccine eff...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399474/ https://www.ncbi.nlm.nih.gov/pubmed/37529935 http://dx.doi.org/10.1080/21645515.2023.2239085 |
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author | Ellingson, Mallory K. Sheikha, Hassan Nyhan, Kate Oliveira, Carlos R. Niccolai, Linda M. |
author_facet | Ellingson, Mallory K. Sheikha, Hassan Nyhan, Kate Oliveira, Carlos R. Niccolai, Linda M. |
author_sort | Ellingson, Mallory K. |
collection | PubMed |
description | Human papillomavirus (HPV) vaccines work by preventing infections prior to natural exposure. Thus, it is likely more effective at younger ages, and it is important to understand how effectiveness might be diminished when administered at older ages. We conducted a systematic review of HPV vaccine effectiveness studies published between 2007 and 2022 that included an analysis of effectiveness against vaccine-type HPV infections, anogenital warts, cervical abnormalities and cervical cancer by age at vaccine initiation or completion. Searching multiple databases, 21 studies were included and results were summarized descriptively. Seventeen studies found the highest vaccine effectiveness in the youngest age group. Vaccine effectiveness estimates for younger adolescents ages 9–14 years ranged from approximately 74% to 93% and from 12% to 90% for adolescents ages 15–18 years. These results demonstrate that the HPV vaccine is most effective against HPV-related disease outcomes when given at younger ages, emphasizing the importance of on-time vaccination. |
format | Online Article Text |
id | pubmed-10399474 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-103994742023-08-04 Human papillomavirus vaccine effectiveness by age at vaccination: A systematic review Ellingson, Mallory K. Sheikha, Hassan Nyhan, Kate Oliveira, Carlos R. Niccolai, Linda M. Hum Vaccin Immunother HPV Human papillomavirus (HPV) vaccines work by preventing infections prior to natural exposure. Thus, it is likely more effective at younger ages, and it is important to understand how effectiveness might be diminished when administered at older ages. We conducted a systematic review of HPV vaccine effectiveness studies published between 2007 and 2022 that included an analysis of effectiveness against vaccine-type HPV infections, anogenital warts, cervical abnormalities and cervical cancer by age at vaccine initiation or completion. Searching multiple databases, 21 studies were included and results were summarized descriptively. Seventeen studies found the highest vaccine effectiveness in the youngest age group. Vaccine effectiveness estimates for younger adolescents ages 9–14 years ranged from approximately 74% to 93% and from 12% to 90% for adolescents ages 15–18 years. These results demonstrate that the HPV vaccine is most effective against HPV-related disease outcomes when given at younger ages, emphasizing the importance of on-time vaccination. Taylor & Francis 2023-08-02 /pmc/articles/PMC10399474/ /pubmed/37529935 http://dx.doi.org/10.1080/21645515.2023.2239085 Text en © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. |
spellingShingle | HPV Ellingson, Mallory K. Sheikha, Hassan Nyhan, Kate Oliveira, Carlos R. Niccolai, Linda M. Human papillomavirus vaccine effectiveness by age at vaccination: A systematic review |
title | Human papillomavirus vaccine effectiveness by age at vaccination: A systematic review |
title_full | Human papillomavirus vaccine effectiveness by age at vaccination: A systematic review |
title_fullStr | Human papillomavirus vaccine effectiveness by age at vaccination: A systematic review |
title_full_unstemmed | Human papillomavirus vaccine effectiveness by age at vaccination: A systematic review |
title_short | Human papillomavirus vaccine effectiveness by age at vaccination: A systematic review |
title_sort | human papillomavirus vaccine effectiveness by age at vaccination: a systematic review |
topic | HPV |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399474/ https://www.ncbi.nlm.nih.gov/pubmed/37529935 http://dx.doi.org/10.1080/21645515.2023.2239085 |
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