Research progress of LINE-1 in the diagnosis, prognosis, and treatment of gynecologic tumors

The retrotransposon known as long interspersed nuclear element-1 (LINE-1), which is currently the sole autonomously mobile transposon in the human genome, can result in insertional mutations, chromosomal rearrangements, and genomic instability. In recent years, numerous studies have shown that LINE-...

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Autores principales: Fu, Jiaojiao, Qin, Tiansheng, Li, Chaoming, Zhu, Jiaojiao, Ding, Yaoyao, Zhou, Meiying, Yang, Qing, Liu, Xiaofeng, Zhou, Juanhong, Chen, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399582/
https://www.ncbi.nlm.nih.gov/pubmed/37546391
http://dx.doi.org/10.3389/fonc.2023.1201568
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author Fu, Jiaojiao
Qin, Tiansheng
Li, Chaoming
Zhu, Jiaojiao
Ding, Yaoyao
Zhou, Meiying
Yang, Qing
Liu, Xiaofeng
Zhou, Juanhong
Chen, Fan
author_facet Fu, Jiaojiao
Qin, Tiansheng
Li, Chaoming
Zhu, Jiaojiao
Ding, Yaoyao
Zhou, Meiying
Yang, Qing
Liu, Xiaofeng
Zhou, Juanhong
Chen, Fan
author_sort Fu, Jiaojiao
collection PubMed
description The retrotransposon known as long interspersed nuclear element-1 (LINE-1), which is currently the sole autonomously mobile transposon in the human genome, can result in insertional mutations, chromosomal rearrangements, and genomic instability. In recent years, numerous studies have shown that LINE-1 is involved in the development of various diseases and also plays an important role in the immune regulation of the organism. The expression of LINE-1 in gynecologic tumors suggests that it is expected to be an independent indicator for early diagnosis and prognosis, and also, as a therapeutic target, LINE-1 is closely associated with gynecologic tumor prognosis. This article discusses the function of LINE-1 in the diagnosis, treatment, and prognosis of ovarian, cervical, and endometrial malignancies, as well as other gynecologic malignancies. It offers fresh perspectives on the early detection of tumors and the creation of novel anti-tumor medications.
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spelling pubmed-103995822023-08-04 Research progress of LINE-1 in the diagnosis, prognosis, and treatment of gynecologic tumors Fu, Jiaojiao Qin, Tiansheng Li, Chaoming Zhu, Jiaojiao Ding, Yaoyao Zhou, Meiying Yang, Qing Liu, Xiaofeng Zhou, Juanhong Chen, Fan Front Oncol Oncology The retrotransposon known as long interspersed nuclear element-1 (LINE-1), which is currently the sole autonomously mobile transposon in the human genome, can result in insertional mutations, chromosomal rearrangements, and genomic instability. In recent years, numerous studies have shown that LINE-1 is involved in the development of various diseases and also plays an important role in the immune regulation of the organism. The expression of LINE-1 in gynecologic tumors suggests that it is expected to be an independent indicator for early diagnosis and prognosis, and also, as a therapeutic target, LINE-1 is closely associated with gynecologic tumor prognosis. This article discusses the function of LINE-1 in the diagnosis, treatment, and prognosis of ovarian, cervical, and endometrial malignancies, as well as other gynecologic malignancies. It offers fresh perspectives on the early detection of tumors and the creation of novel anti-tumor medications. Frontiers Media S.A. 2023-07-20 /pmc/articles/PMC10399582/ /pubmed/37546391 http://dx.doi.org/10.3389/fonc.2023.1201568 Text en Copyright © 2023 Fu, Qin, Li, Zhu, Ding, Zhou, Yang, Liu, Zhou and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Fu, Jiaojiao
Qin, Tiansheng
Li, Chaoming
Zhu, Jiaojiao
Ding, Yaoyao
Zhou, Meiying
Yang, Qing
Liu, Xiaofeng
Zhou, Juanhong
Chen, Fan
Research progress of LINE-1 in the diagnosis, prognosis, and treatment of gynecologic tumors
title Research progress of LINE-1 in the diagnosis, prognosis, and treatment of gynecologic tumors
title_full Research progress of LINE-1 in the diagnosis, prognosis, and treatment of gynecologic tumors
title_fullStr Research progress of LINE-1 in the diagnosis, prognosis, and treatment of gynecologic tumors
title_full_unstemmed Research progress of LINE-1 in the diagnosis, prognosis, and treatment of gynecologic tumors
title_short Research progress of LINE-1 in the diagnosis, prognosis, and treatment of gynecologic tumors
title_sort research progress of line-1 in the diagnosis, prognosis, and treatment of gynecologic tumors
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399582/
https://www.ncbi.nlm.nih.gov/pubmed/37546391
http://dx.doi.org/10.3389/fonc.2023.1201568
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