EGFR-selective activation of CD27 co-stimulatory signaling by a bispecific antibody enhances anti-tumor activity of T cells

A higher density of tumor infiltrating lymphocytes (TILs) in the tumor microenvironment, particularly cytotoxic CD8(+) T cells, is associated with improved clinical outcome in various cancers. However, local inhibitory factors can suppress T cell activity and hinder anti-tumor immunity. Notably, TIL...

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Detalles Bibliográficos
Autores principales: Melo, Vinicio, Nelemans, Levi Collin, Vlaming, Martijn, Lourens, Harm Jan, Wiersma, Valerie R., Bilemjian, Vrouyr, Huls, Gerwin, de Bruyn, Marco, Bremer, Edwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399592/
https://www.ncbi.nlm.nih.gov/pubmed/37545491
http://dx.doi.org/10.3389/fimmu.2023.1191866

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