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Eye-tracking paradigms for the assessment of mild cognitive impairment: a systematic review

Mild cognitive impairment (MCI), representing the ‘transitional zone’ between normal cognition and dementia, has become a novel topic in clinical research. Although early detection is crucial, it remains logistically challenging at the same time. While traditional pen-and-paper tests require in-dept...

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Autores principales: Wolf, Alexandra, Tripanpitak, Kornkanok, Umeda, Satoshi, Otake-Matsuura, Mihoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399700/
https://www.ncbi.nlm.nih.gov/pubmed/37546488
http://dx.doi.org/10.3389/fpsyg.2023.1197567
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author Wolf, Alexandra
Tripanpitak, Kornkanok
Umeda, Satoshi
Otake-Matsuura, Mihoko
author_facet Wolf, Alexandra
Tripanpitak, Kornkanok
Umeda, Satoshi
Otake-Matsuura, Mihoko
author_sort Wolf, Alexandra
collection PubMed
description Mild cognitive impairment (MCI), representing the ‘transitional zone’ between normal cognition and dementia, has become a novel topic in clinical research. Although early detection is crucial, it remains logistically challenging at the same time. While traditional pen-and-paper tests require in-depth training to ensure standardized administration and accurate interpretation of findings, significant technological advancements are leading to the development of procedures for the early detection of Alzheimer’s disease (AD) and facilitating the diagnostic process. Some of the diagnostic protocols, however, show significant limitations that hamper their widespread adoption. Concerns about the social and economic implications of the increasing incidence of AD underline the need for reliable, non-invasive, cost-effective, and timely cognitive scoring methodologies. For instance, modern clinical studies report significant oculomotor impairments among patients with MCI, who perform poorly in visual paired-comparison tasks by ascribing less attentional resources to novel stimuli. To accelerate the Global Action Plan on the Public Health Response to Dementia 2017–2025, this work provides an overview of research on saccadic and exploratory eye-movement deficits among older adults with MCI. The review protocol was drafted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Electronic databases were systematically searched to identify peer-reviewed articles published between 2017 and 2022 that examined visual processing in older adults with MCI and reported gaze parameters as potential biomarkers. Moreover, following the contemporary trend for remote healthcare technologies, we reviewed studies that implemented non-commercial eye-tracking instrumentation in order to detect information processing impairments among the MCI population. Based on the gathered literature, eye-tracking-based paradigms may ameliorate the screening limitations of traditional cognitive assessments and contribute to early AD detection. However, in order to translate the findings pertaining to abnormal gaze behavior into clinical applications, it is imperative to conduct longitudinal investigations in both laboratory-based and ecologically valid settings.
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spelling pubmed-103997002023-08-04 Eye-tracking paradigms for the assessment of mild cognitive impairment: a systematic review Wolf, Alexandra Tripanpitak, Kornkanok Umeda, Satoshi Otake-Matsuura, Mihoko Front Psychol Psychology Mild cognitive impairment (MCI), representing the ‘transitional zone’ between normal cognition and dementia, has become a novel topic in clinical research. Although early detection is crucial, it remains logistically challenging at the same time. While traditional pen-and-paper tests require in-depth training to ensure standardized administration and accurate interpretation of findings, significant technological advancements are leading to the development of procedures for the early detection of Alzheimer’s disease (AD) and facilitating the diagnostic process. Some of the diagnostic protocols, however, show significant limitations that hamper their widespread adoption. Concerns about the social and economic implications of the increasing incidence of AD underline the need for reliable, non-invasive, cost-effective, and timely cognitive scoring methodologies. For instance, modern clinical studies report significant oculomotor impairments among patients with MCI, who perform poorly in visual paired-comparison tasks by ascribing less attentional resources to novel stimuli. To accelerate the Global Action Plan on the Public Health Response to Dementia 2017–2025, this work provides an overview of research on saccadic and exploratory eye-movement deficits among older adults with MCI. The review protocol was drafted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Electronic databases were systematically searched to identify peer-reviewed articles published between 2017 and 2022 that examined visual processing in older adults with MCI and reported gaze parameters as potential biomarkers. Moreover, following the contemporary trend for remote healthcare technologies, we reviewed studies that implemented non-commercial eye-tracking instrumentation in order to detect information processing impairments among the MCI population. Based on the gathered literature, eye-tracking-based paradigms may ameliorate the screening limitations of traditional cognitive assessments and contribute to early AD detection. However, in order to translate the findings pertaining to abnormal gaze behavior into clinical applications, it is imperative to conduct longitudinal investigations in both laboratory-based and ecologically valid settings. Frontiers Media S.A. 2023-07-20 /pmc/articles/PMC10399700/ /pubmed/37546488 http://dx.doi.org/10.3389/fpsyg.2023.1197567 Text en Copyright © 2023 Wolf, Tripanpitak, Umeda and Otake-Matsuura. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychology
Wolf, Alexandra
Tripanpitak, Kornkanok
Umeda, Satoshi
Otake-Matsuura, Mihoko
Eye-tracking paradigms for the assessment of mild cognitive impairment: a systematic review
title Eye-tracking paradigms for the assessment of mild cognitive impairment: a systematic review
title_full Eye-tracking paradigms for the assessment of mild cognitive impairment: a systematic review
title_fullStr Eye-tracking paradigms for the assessment of mild cognitive impairment: a systematic review
title_full_unstemmed Eye-tracking paradigms for the assessment of mild cognitive impairment: a systematic review
title_short Eye-tracking paradigms for the assessment of mild cognitive impairment: a systematic review
title_sort eye-tracking paradigms for the assessment of mild cognitive impairment: a systematic review
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399700/
https://www.ncbi.nlm.nih.gov/pubmed/37546488
http://dx.doi.org/10.3389/fpsyg.2023.1197567
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