Cargando…

Extracellular LGALS3BP: a potential disease marker and actionable target for antibody–drug conjugate therapy in glioblastoma

Glioblastoma multiforme (GBM) is a lethal disease characterized by an overall survival of about 1 year, making it one of the most aggressive tumours, with very limited therapeutic possibilities. Specific biomarkers for early diagnosis as well as innovative therapeutic strategies are urgently needed...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dufrusine, Beatrice, Capone, Emily, Ponziani, Sara, Lattanzio, Rossano, Lanuti, Paola, Giansanti, Francesco, De Laurenzi, Vincenzo, Iacobelli, Stefano, Ippoliti, Rodolfo, Mangiola, Annunziato, Trevisi, Gianluca, Sala, Gianluca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399712/ https://www.ncbi.nlm.nih.gov/pubmed/37195369 http://dx.doi.org/10.1002/1878-0261.13453

Ejemplares similares

Targeting Vesicular LGALS3BP by an Antibody-Drug Conjugate as Novel Therapeutic Strategy for Neuroblastoma
por: Capone, Emily, et al.
Publicado: (2020)

Prognostic relevance of LGALS3BP in human colorectal carcinoma
por: Piccolo, Enza, et al.
Publicado: (2015)

EV20-Sap, a novel anti-HER-3 antibody-drug conjugate, displays promising antitumor activity in melanoma
por: Capone, Emily, et al.
Publicado: (2017)

Current Knowledge about the Peritumoral Microenvironment in Glioblastoma
por: Trevisi, Gianluca, et al.
Publicado: (2023)

Antibody-Drug Conjugates: The New Frontier of Chemotherapy
por: Ponziani, Sara, et al.
Publicado: (2020)

EV20/NMS-P945, a Novel Thienoindole Based Antibody-Drug Conjugate Targeting HER-3 for Solid Tumors
por: Capone, Emily, et al.
Publicado: (2021)

HER-3 surface expression increases in advanced colorectal cancer representing a potential therapeutic target
por: Capone, Emily, et al.
Publicado: (2023)

Circulating Autoantibodies to LGALS3BP: A Novel Biomarker for Cancer
por: Grassadonia, Antonino, et al.
Publicado: (2013)

Generation of a novel Antibody-Drug Conjugate targeting endosialin: potent and durable antitumor response in sarcoma
por: Capone, Emily, et al.
Publicado: (2017)

The interference of Notch1 target Hes1 affects cell growth, differentiation and invasiveness of glioblastoma stem cells through modulation of multiple oncogenic targets
por: Cenciarelli, Carlo, et al.
Publicado: (2017)

Intraoperative thermal infrared imaging in neurosurgery: machine learning approaches for advanced segmentation of tumors
por: Cardone, Daniela, et al.
Publicado: (2023)

HER3 targeting with an antibody‐drug conjugate bypasses resistance to anti‐HER2 therapies
por: Gandullo‐Sánchez, Lucía, et al.
Publicado: (2020)

Immunohistochemical Characterization of Immune Infiltrate in Tumor Microenvironment of Glioblastoma
por: Rahimi Koshkaki, Hassan, et al.
Publicado: (2020)

Usefulness of Brain Positron Emission Tomography with Different Tracers in the Evaluation of Patients with Idiopathic Normal Pressure Hydrocephalous
por: Mattoli, Maria Vittoria, et al.
Publicado: (2020)

Role of galectin 3 binding protein in cancer progression: a potential novel therapeutic target
por: Capone, Emily, et al.
Publicado: (2021)

USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer
por: Rossi, Fabiana Alejandra, et al.
Publicado: (2021)

The Antiviral Activity of the Cellular Glycoprotein LGALS3BP/90K Is Species Specific
por: Lodermeyer, Veronika, et al.
Publicado: (2018)

Preclinical validation of 3-phosphoinositide-dependent protein kinase 1 inhibition in pancreatic cancer
por: Emmanouilidi, Aikaterini, et al.
Publicado: (2019)

90K/LGALS3BP expression is upregulated in COVID-19 but may not restrict SARS-CoV-2 infection
por: Bosquillon de Jarcy, Laure, et al.
Publicado: (2023)

Investigating LGALS3BP/90 K glycoprotein in the cerebrospinal fluid of patients with neurological diseases
por: Costa, Júlia, et al.
Publicado: (2020)

Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity
por: Kyrousi, Christina, et al.
Publicado: (2021)

LGALS3BP: A Potential Plasma Biomarker Associated with Diagnosis and Prognosis in Patients with Sepsis
por: Luo, Meiyan, et al.
Publicado: (2021)

Aptamer-Driven Toxin Gene Delivery in U87 Model Glioblastoma Cells
por: di Leandro, Luana, et al.
Publicado: (2021)

Visualizing Galectin-3 Binding Protein Expression with ImmunoPET
por: Keinänen, Outi, et al.
Publicado: (2023)

Antiplatelet/Anticoagulant Agents and Chronic Subdural Hematoma in the Elderly
por: De Bonis, Pasquale, et al.
Publicado: (2013)

Glioblastoma stem cells express non‐canonical proteins and exclusive mesenchymal‐like or non‐mesenchymal‐like protein signatures
por: Babačić, Haris, et al.
Publicado: (2023)

The lncRNA H19 positively affects the tumorigenic properties of glioblastoma cells and contributes to NKD1 repression through the recruitment of EZH2 on its promoter
por: Fazi, Barbara, et al.
Publicado: (2018)

BAG3 induces fibroblasts to release key cytokines involved in pancreatic cell migration
por: Dufrusine, Beatrice, et al.
Publicado: (2021)

Single‐cell profiling and zebrafish avatars reveal LGALS1 as immunomodulating target in glioblastoma
por: Finotto, Lise, et al.
Publicado: (2023)

Lgals3bp suppresses colon inflammation and tumorigenesis through the downregulation of TAK1-NF-κB signaling
por: Cho, Sang-Hee, et al.
Publicado: (2021)

LGALS3BP in Microglia Promotes Retinal Angiogenesis Through PI3K/AKT Pathway During Hypoxia
por: Zhao, Chenyang, et al.
Publicado: (2022)

ErbB-3 activation by NRG-1β sustains growth and promotes vemurafenib resistance in BRAF-V600E colon cancer stem cells (CSCs)
por: Prasetyanti, Pramudita R., et al.
Publicado: (2015)

Increased LGALS3 expression independently predicts shorter overall survival in patients with the proneural subtype of glioblastoma
por: He, Xia, et al.
Publicado: (2019)

Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex
por: Xu, Gang, et al.
Publicado: (2019)

Innovative Therapies against Human Glioblastoma Multiforme
por: Cimini, Annamaria, et al.
Publicado: (2011)

The Expression of the Chemokine CXCL14 Correlates with Several Aggressive Aspects of Glioblastoma and Promotes Key Properties of Glioblastoma Cells
por: Fazi, Barbara, et al.
Publicado: (2019)

Dual targeting of ErbB-2/ErbB-3 results in enhanced antitumor activity in preclinical models of pancreatic cancer
por: Ghasemi, R, et al.
Publicado: (2014)

CD276 and the gene signature composed of GATA3 and LGALS3 enable prognosis prediction of glioblastoma multiforme
por: Takashima, Yasuo, et al.
Publicado: (2019)

Validation of Salivary Markers, IL-1β, IL-8 and Lgals3bp for Detection of Oral Squamous Cell Carcinoma in an Indian Population
por: Singh, Prerana, et al.
Publicado: (2020)

Suppression of triple-negative breast cancer aggressiveness by LGALS3BP via inhibition of the TNF-α–TAK1–MMP9 axis
por: Sun, Eun-Gene, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_clgnl8gjig3mceecqjbu3aj2ss