Cargando…

Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis

Ulcerative colitis (UC) is presently considered a multifactorial pathology, which may lead to persistent inflammatory action of the gastrointestinal tract (GIT) because of an improperly managed immunological reactivity to the intestinal microbiota found in the GIT. The immune response to common comm...

Descripción completa

Detalles Bibliográficos
Autores principales: Ashique, Sumel, Mishra, Neeraj, Garg, Ashish, Sibuh, Belay Zeleke, Taneja, Pankaj, Rai, Gopal, Djearamane, Sinouvassane, Wong, Ling Shing, Al-Dayan, Noura, Roychoudhury, Shatabhisha, Kesari, Kavindra Kumar, Slama, Petr, Roychoudhury, Shubhadeep, Gupta, Piyush Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400011/
https://www.ncbi.nlm.nih.gov/pubmed/37545572
http://dx.doi.org/10.3389/fnut.2023.1126579
_version_ 1785084374134292480
author Ashique, Sumel
Mishra, Neeraj
Garg, Ashish
Sibuh, Belay Zeleke
Taneja, Pankaj
Rai, Gopal
Djearamane, Sinouvassane
Wong, Ling Shing
Al-Dayan, Noura
Roychoudhury, Shatabhisha
Kesari, Kavindra Kumar
Slama, Petr
Roychoudhury, Shubhadeep
Gupta, Piyush Kumar
author_facet Ashique, Sumel
Mishra, Neeraj
Garg, Ashish
Sibuh, Belay Zeleke
Taneja, Pankaj
Rai, Gopal
Djearamane, Sinouvassane
Wong, Ling Shing
Al-Dayan, Noura
Roychoudhury, Shatabhisha
Kesari, Kavindra Kumar
Slama, Petr
Roychoudhury, Shubhadeep
Gupta, Piyush Kumar
author_sort Ashique, Sumel
collection PubMed
description Ulcerative colitis (UC) is presently considered a multifactorial pathology, which may lead to persistent inflammatory action of the gastrointestinal tract (GIT) because of an improperly managed immunological reactivity to the intestinal microbiota found in the GIT. The immune response to common commensal microbes plays an essential role in intestinal inflammation related to UC synbiotics, and it is an important element in the optimal therapy of UC. Therefore, synbiotics, i.e., a mixture of prebiotics and probiotics, may help control the diseased state. Synbiotics alleviate the inflammation of the colon by lowering the reactive oxygen species (ROS) and improving the level of antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GPX), and superoxide dismutase (SOD). Prebiotic supplementation is not a common practice at the moment, despite numerous research findings proving that the benefits of both probiotics and prebiotics encourage their continued existence and positioning in the GIT, with positive effects on human health by managing the inflammatory response. However, the fact that there have been fewer studies on the treatment of UC with different probiotics coupled with selected prebiotics, i.e., synbiotics, and the outcomes of these studies have been very favorable. This evidence-based study explores the possible role of ROS, SOD, and synbiotics in managing the UC. The proposed review also focuses on the role of alteration of gut microbiota, antioxidant defense in the gastrointestinal tract, and the management of UC. Thus, the current article emphasizes oxidative stress signaling in the GI tract, oxidative stress-based pathomechanisms in UC patients, and UC therapies inhibiting oxidative stress’ effects.
format Online
Article
Text
id pubmed-10400011
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-104000112023-08-04 Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis Ashique, Sumel Mishra, Neeraj Garg, Ashish Sibuh, Belay Zeleke Taneja, Pankaj Rai, Gopal Djearamane, Sinouvassane Wong, Ling Shing Al-Dayan, Noura Roychoudhury, Shatabhisha Kesari, Kavindra Kumar Slama, Petr Roychoudhury, Shubhadeep Gupta, Piyush Kumar Front Nutr Nutrition Ulcerative colitis (UC) is presently considered a multifactorial pathology, which may lead to persistent inflammatory action of the gastrointestinal tract (GIT) because of an improperly managed immunological reactivity to the intestinal microbiota found in the GIT. The immune response to common commensal microbes plays an essential role in intestinal inflammation related to UC synbiotics, and it is an important element in the optimal therapy of UC. Therefore, synbiotics, i.e., a mixture of prebiotics and probiotics, may help control the diseased state. Synbiotics alleviate the inflammation of the colon by lowering the reactive oxygen species (ROS) and improving the level of antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GPX), and superoxide dismutase (SOD). Prebiotic supplementation is not a common practice at the moment, despite numerous research findings proving that the benefits of both probiotics and prebiotics encourage their continued existence and positioning in the GIT, with positive effects on human health by managing the inflammatory response. However, the fact that there have been fewer studies on the treatment of UC with different probiotics coupled with selected prebiotics, i.e., synbiotics, and the outcomes of these studies have been very favorable. This evidence-based study explores the possible role of ROS, SOD, and synbiotics in managing the UC. The proposed review also focuses on the role of alteration of gut microbiota, antioxidant defense in the gastrointestinal tract, and the management of UC. Thus, the current article emphasizes oxidative stress signaling in the GI tract, oxidative stress-based pathomechanisms in UC patients, and UC therapies inhibiting oxidative stress’ effects. Frontiers Media S.A. 2023-07-20 /pmc/articles/PMC10400011/ /pubmed/37545572 http://dx.doi.org/10.3389/fnut.2023.1126579 Text en Copyright © 2023 Ashique, Mishra, Garg, Sibuh, Taneja, Rai, Djearamane, Wong, Al-Dayan, Roychoudhury, Kesari, Slama, Roychoudhury and Gupta. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Ashique, Sumel
Mishra, Neeraj
Garg, Ashish
Sibuh, Belay Zeleke
Taneja, Pankaj
Rai, Gopal
Djearamane, Sinouvassane
Wong, Ling Shing
Al-Dayan, Noura
Roychoudhury, Shatabhisha
Kesari, Kavindra Kumar
Slama, Petr
Roychoudhury, Shubhadeep
Gupta, Piyush Kumar
Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis
title Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis
title_full Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis
title_fullStr Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis
title_full_unstemmed Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis
title_short Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis
title_sort recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400011/
https://www.ncbi.nlm.nih.gov/pubmed/37545572
http://dx.doi.org/10.3389/fnut.2023.1126579
work_keys_str_mv AT ashiquesumel recentupdatesoncorrelationbetweenreactiveoxygenspeciesandsynbioticsforeffectivemanagementofulcerativecolitis
AT mishraneeraj recentupdatesoncorrelationbetweenreactiveoxygenspeciesandsynbioticsforeffectivemanagementofulcerativecolitis
AT gargashish recentupdatesoncorrelationbetweenreactiveoxygenspeciesandsynbioticsforeffectivemanagementofulcerativecolitis
AT sibuhbelayzeleke recentupdatesoncorrelationbetweenreactiveoxygenspeciesandsynbioticsforeffectivemanagementofulcerativecolitis
AT tanejapankaj recentupdatesoncorrelationbetweenreactiveoxygenspeciesandsynbioticsforeffectivemanagementofulcerativecolitis
AT raigopal recentupdatesoncorrelationbetweenreactiveoxygenspeciesandsynbioticsforeffectivemanagementofulcerativecolitis
AT djearamanesinouvassane recentupdatesoncorrelationbetweenreactiveoxygenspeciesandsynbioticsforeffectivemanagementofulcerativecolitis
AT wonglingshing recentupdatesoncorrelationbetweenreactiveoxygenspeciesandsynbioticsforeffectivemanagementofulcerativecolitis
AT aldayannoura recentupdatesoncorrelationbetweenreactiveoxygenspeciesandsynbioticsforeffectivemanagementofulcerativecolitis
AT roychoudhuryshatabhisha recentupdatesoncorrelationbetweenreactiveoxygenspeciesandsynbioticsforeffectivemanagementofulcerativecolitis
AT kesarikavindrakumar recentupdatesoncorrelationbetweenreactiveoxygenspeciesandsynbioticsforeffectivemanagementofulcerativecolitis
AT slamapetr recentupdatesoncorrelationbetweenreactiveoxygenspeciesandsynbioticsforeffectivemanagementofulcerativecolitis
AT roychoudhuryshubhadeep recentupdatesoncorrelationbetweenreactiveoxygenspeciesandsynbioticsforeffectivemanagementofulcerativecolitis
AT guptapiyushkumar recentupdatesoncorrelationbetweenreactiveoxygenspeciesandsynbioticsforeffectivemanagementofulcerativecolitis