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Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis
Ulcerative colitis (UC) is presently considered a multifactorial pathology, which may lead to persistent inflammatory action of the gastrointestinal tract (GIT) because of an improperly managed immunological reactivity to the intestinal microbiota found in the GIT. The immune response to common comm...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400011/ https://www.ncbi.nlm.nih.gov/pubmed/37545572 http://dx.doi.org/10.3389/fnut.2023.1126579 |
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author | Ashique, Sumel Mishra, Neeraj Garg, Ashish Sibuh, Belay Zeleke Taneja, Pankaj Rai, Gopal Djearamane, Sinouvassane Wong, Ling Shing Al-Dayan, Noura Roychoudhury, Shatabhisha Kesari, Kavindra Kumar Slama, Petr Roychoudhury, Shubhadeep Gupta, Piyush Kumar |
author_facet | Ashique, Sumel Mishra, Neeraj Garg, Ashish Sibuh, Belay Zeleke Taneja, Pankaj Rai, Gopal Djearamane, Sinouvassane Wong, Ling Shing Al-Dayan, Noura Roychoudhury, Shatabhisha Kesari, Kavindra Kumar Slama, Petr Roychoudhury, Shubhadeep Gupta, Piyush Kumar |
author_sort | Ashique, Sumel |
collection | PubMed |
description | Ulcerative colitis (UC) is presently considered a multifactorial pathology, which may lead to persistent inflammatory action of the gastrointestinal tract (GIT) because of an improperly managed immunological reactivity to the intestinal microbiota found in the GIT. The immune response to common commensal microbes plays an essential role in intestinal inflammation related to UC synbiotics, and it is an important element in the optimal therapy of UC. Therefore, synbiotics, i.e., a mixture of prebiotics and probiotics, may help control the diseased state. Synbiotics alleviate the inflammation of the colon by lowering the reactive oxygen species (ROS) and improving the level of antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GPX), and superoxide dismutase (SOD). Prebiotic supplementation is not a common practice at the moment, despite numerous research findings proving that the benefits of both probiotics and prebiotics encourage their continued existence and positioning in the GIT, with positive effects on human health by managing the inflammatory response. However, the fact that there have been fewer studies on the treatment of UC with different probiotics coupled with selected prebiotics, i.e., synbiotics, and the outcomes of these studies have been very favorable. This evidence-based study explores the possible role of ROS, SOD, and synbiotics in managing the UC. The proposed review also focuses on the role of alteration of gut microbiota, antioxidant defense in the gastrointestinal tract, and the management of UC. Thus, the current article emphasizes oxidative stress signaling in the GI tract, oxidative stress-based pathomechanisms in UC patients, and UC therapies inhibiting oxidative stress’ effects. |
format | Online Article Text |
id | pubmed-10400011 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104000112023-08-04 Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis Ashique, Sumel Mishra, Neeraj Garg, Ashish Sibuh, Belay Zeleke Taneja, Pankaj Rai, Gopal Djearamane, Sinouvassane Wong, Ling Shing Al-Dayan, Noura Roychoudhury, Shatabhisha Kesari, Kavindra Kumar Slama, Petr Roychoudhury, Shubhadeep Gupta, Piyush Kumar Front Nutr Nutrition Ulcerative colitis (UC) is presently considered a multifactorial pathology, which may lead to persistent inflammatory action of the gastrointestinal tract (GIT) because of an improperly managed immunological reactivity to the intestinal microbiota found in the GIT. The immune response to common commensal microbes plays an essential role in intestinal inflammation related to UC synbiotics, and it is an important element in the optimal therapy of UC. Therefore, synbiotics, i.e., a mixture of prebiotics and probiotics, may help control the diseased state. Synbiotics alleviate the inflammation of the colon by lowering the reactive oxygen species (ROS) and improving the level of antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GPX), and superoxide dismutase (SOD). Prebiotic supplementation is not a common practice at the moment, despite numerous research findings proving that the benefits of both probiotics and prebiotics encourage their continued existence and positioning in the GIT, with positive effects on human health by managing the inflammatory response. However, the fact that there have been fewer studies on the treatment of UC with different probiotics coupled with selected prebiotics, i.e., synbiotics, and the outcomes of these studies have been very favorable. This evidence-based study explores the possible role of ROS, SOD, and synbiotics in managing the UC. The proposed review also focuses on the role of alteration of gut microbiota, antioxidant defense in the gastrointestinal tract, and the management of UC. Thus, the current article emphasizes oxidative stress signaling in the GI tract, oxidative stress-based pathomechanisms in UC patients, and UC therapies inhibiting oxidative stress’ effects. Frontiers Media S.A. 2023-07-20 /pmc/articles/PMC10400011/ /pubmed/37545572 http://dx.doi.org/10.3389/fnut.2023.1126579 Text en Copyright © 2023 Ashique, Mishra, Garg, Sibuh, Taneja, Rai, Djearamane, Wong, Al-Dayan, Roychoudhury, Kesari, Slama, Roychoudhury and Gupta. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Ashique, Sumel Mishra, Neeraj Garg, Ashish Sibuh, Belay Zeleke Taneja, Pankaj Rai, Gopal Djearamane, Sinouvassane Wong, Ling Shing Al-Dayan, Noura Roychoudhury, Shatabhisha Kesari, Kavindra Kumar Slama, Petr Roychoudhury, Shubhadeep Gupta, Piyush Kumar Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis |
title | Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis |
title_full | Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis |
title_fullStr | Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis |
title_full_unstemmed | Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis |
title_short | Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis |
title_sort | recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400011/ https://www.ncbi.nlm.nih.gov/pubmed/37545572 http://dx.doi.org/10.3389/fnut.2023.1126579 |
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