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Diagnosis and management of adult central nervous system leukemia

Central nervous system leukemia (CNSL) is a prominent infiltration reason for therapy failing in acute leukemia. Recurrence rates and the prognosis have alleviated with current prophylactic regimens. However, the accurate stratification of relapse risk and treatment regimens for relapsed or refracto...

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Autores principales: Liu, Siyu, Wang, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400053/
https://www.ncbi.nlm.nih.gov/pubmed/37546706
http://dx.doi.org/10.1097/BS9.0000000000000162
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author Liu, Siyu
Wang, Ying
author_facet Liu, Siyu
Wang, Ying
author_sort Liu, Siyu
collection PubMed
description Central nervous system leukemia (CNSL) is a prominent infiltration reason for therapy failing in acute leukemia. Recurrence rates and the prognosis have alleviated with current prophylactic regimens. However, the accurate stratification of relapse risk and treatment regimens for relapsed or refractory patients remain clinical challenges yet to be solved. Recently, with hematopoietic stem cell transplantation (HSCT) and chimeric antigen receptor-T (CAR-T) cellular therapy showing encouraging effects in some CNSL patients, advances in treating CNSL have already been reported. The development of molecular targeted agents as well as antibody-based drugs will provide patients with more personalized treatment. This article summarized recent research developments about risk factors, diagnosis, prevention, and treatment in adults with CNSL.
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spelling pubmed-104000532023-08-04 Diagnosis and management of adult central nervous system leukemia Liu, Siyu Wang, Ying Blood Sci Review Articles Central nervous system leukemia (CNSL) is a prominent infiltration reason for therapy failing in acute leukemia. Recurrence rates and the prognosis have alleviated with current prophylactic regimens. However, the accurate stratification of relapse risk and treatment regimens for relapsed or refractory patients remain clinical challenges yet to be solved. Recently, with hematopoietic stem cell transplantation (HSCT) and chimeric antigen receptor-T (CAR-T) cellular therapy showing encouraging effects in some CNSL patients, advances in treating CNSL have already been reported. The development of molecular targeted agents as well as antibody-based drugs will provide patients with more personalized treatment. This article summarized recent research developments about risk factors, diagnosis, prevention, and treatment in adults with CNSL. Lippincott Williams & Wilkins 2023-05-30 /pmc/articles/PMC10400053/ /pubmed/37546706 http://dx.doi.org/10.1097/BS9.0000000000000162 Text en Copyright © 2023 The Authors. Published by Wolters Kluwer Health Inc., on behalf of the Chinese Medical Association (CMA) and Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College (IHCAMS). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Review Articles
Liu, Siyu
Wang, Ying
Diagnosis and management of adult central nervous system leukemia
title Diagnosis and management of adult central nervous system leukemia
title_full Diagnosis and management of adult central nervous system leukemia
title_fullStr Diagnosis and management of adult central nervous system leukemia
title_full_unstemmed Diagnosis and management of adult central nervous system leukemia
title_short Diagnosis and management of adult central nervous system leukemia
title_sort diagnosis and management of adult central nervous system leukemia
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400053/
https://www.ncbi.nlm.nih.gov/pubmed/37546706
http://dx.doi.org/10.1097/BS9.0000000000000162
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