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Diagnosis and management of adult central nervous system leukemia
Central nervous system leukemia (CNSL) is a prominent infiltration reason for therapy failing in acute leukemia. Recurrence rates and the prognosis have alleviated with current prophylactic regimens. However, the accurate stratification of relapse risk and treatment regimens for relapsed or refracto...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400053/ https://www.ncbi.nlm.nih.gov/pubmed/37546706 http://dx.doi.org/10.1097/BS9.0000000000000162 |
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author | Liu, Siyu Wang, Ying |
author_facet | Liu, Siyu Wang, Ying |
author_sort | Liu, Siyu |
collection | PubMed |
description | Central nervous system leukemia (CNSL) is a prominent infiltration reason for therapy failing in acute leukemia. Recurrence rates and the prognosis have alleviated with current prophylactic regimens. However, the accurate stratification of relapse risk and treatment regimens for relapsed or refractory patients remain clinical challenges yet to be solved. Recently, with hematopoietic stem cell transplantation (HSCT) and chimeric antigen receptor-T (CAR-T) cellular therapy showing encouraging effects in some CNSL patients, advances in treating CNSL have already been reported. The development of molecular targeted agents as well as antibody-based drugs will provide patients with more personalized treatment. This article summarized recent research developments about risk factors, diagnosis, prevention, and treatment in adults with CNSL. |
format | Online Article Text |
id | pubmed-10400053 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-104000532023-08-04 Diagnosis and management of adult central nervous system leukemia Liu, Siyu Wang, Ying Blood Sci Review Articles Central nervous system leukemia (CNSL) is a prominent infiltration reason for therapy failing in acute leukemia. Recurrence rates and the prognosis have alleviated with current prophylactic regimens. However, the accurate stratification of relapse risk and treatment regimens for relapsed or refractory patients remain clinical challenges yet to be solved. Recently, with hematopoietic stem cell transplantation (HSCT) and chimeric antigen receptor-T (CAR-T) cellular therapy showing encouraging effects in some CNSL patients, advances in treating CNSL have already been reported. The development of molecular targeted agents as well as antibody-based drugs will provide patients with more personalized treatment. This article summarized recent research developments about risk factors, diagnosis, prevention, and treatment in adults with CNSL. Lippincott Williams & Wilkins 2023-05-30 /pmc/articles/PMC10400053/ /pubmed/37546706 http://dx.doi.org/10.1097/BS9.0000000000000162 Text en Copyright © 2023 The Authors. Published by Wolters Kluwer Health Inc., on behalf of the Chinese Medical Association (CMA) and Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College (IHCAMS). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Review Articles Liu, Siyu Wang, Ying Diagnosis and management of adult central nervous system leukemia |
title | Diagnosis and management of adult central nervous system leukemia |
title_full | Diagnosis and management of adult central nervous system leukemia |
title_fullStr | Diagnosis and management of adult central nervous system leukemia |
title_full_unstemmed | Diagnosis and management of adult central nervous system leukemia |
title_short | Diagnosis and management of adult central nervous system leukemia |
title_sort | diagnosis and management of adult central nervous system leukemia |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400053/ https://www.ncbi.nlm.nih.gov/pubmed/37546706 http://dx.doi.org/10.1097/BS9.0000000000000162 |
work_keys_str_mv | AT liusiyu diagnosisandmanagementofadultcentralnervoussystemleukemia AT wangying diagnosisandmanagementofadultcentralnervoussystemleukemia |