Cargando…

Promoting axon regeneration by inhibiting RNA N6-methyladenosine demethylase ALKBH5

A key limiting factor of successful axon regeneration is the intrinsic regenerative ability in both the peripheral nervous system (PNS) and central nervous system (CNS). Previous studies have identified intrinsic regenerative ability regulators that act on gene expression in injured neurons. However...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Dong, Zheng, Tiemei, Zhou, Songlin, Liu, Mingwen, Liu, Yaobo, Gu, Xiaosong, Mao, Susu, Yu, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400074/ https://www.ncbi.nlm.nih.gov/pubmed/37535403 http://dx.doi.org/10.7554/eLife.85309

Ejemplares similares

The N6-methyladenosine demethylase ALKBH5 regulates the hypoxic HBV transcriptome.
por: Tsukuda, Senko, et al.
Publicado: (2023)

N(6)-methyladenosine demethylases Alkbh5/Fto regulate cerebral ischemia-reperfusion injury
por: Xu, Kaiwei, et al.
Publicado: (2020)

N(6)-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5
por: Zou, Shui, et al.
Publicado: (2016)

N (6) -methyladenosine demethylase ALKBH5: a novel regulator of proliferation and differentiation of chicken preadipocytes : ALKBH5 regulated preadipocyte proliferation and differentiation
por: Zhang, Qi, et al.
Publicado: (2021)

The N(6)-methyladenosine demethylase ALKBH5 negatively regulates the osteogenic differentiation of mesenchymal stem cells through PRMT6
por: Li, Zhaofeng, et al.
Publicado: (2021)

N(6)-methyladenosine binding induces a metal-centered rearrangement that activates the human RNA demethylase Alkbh5
por: Purslow, Jeffrey A., et al.
Publicado: (2021)

N6‐methyladenosine demethylase ALKBH5 suppresses colorectal cancer progression potentially by decreasing PHF20 mRNA methylation
por: Zhang, Zhen, et al.
Publicado: (2022)

Mammalian ALKBH1 serves as an N(6)-mA demethylase of unpairing DNA
por: Zhang, Min, et al.
Publicado: (2020)

RSK1 promotes mammalian axon regeneration by inducing the synthesis of regeneration-related proteins
por: Mao, Susu, et al.
Publicado: (2022)

DNA N(6)-methyladenine demethylase ALKBH1 enhances osteogenic differentiation of human MSCs
por: Zhou, Chenchen, et al.
Publicado: (2016)

ALKBH5 controls the meiosis-coupled mRNA clearance in oocytes by removing the N (6)-methyladenosine methylation
por: Bai, Long, et al.
Publicado: (2023)

Roles of N6‐Methyladenosine Demethylase FTO in Malignant Tumors Progression
por: Zheng, Qing-Kang, et al.
Publicado: (2021)

The biological function of m6A demethylase ALKBH5 and its role in human disease
por: Wang, Jinyan, et al.
Publicado: (2020)

Mechanisms of substrate recognition and N(6)-methyladenosine demethylation revealed by crystal structures of ALKBH5–RNA complexes
por: Kaur, Simranjeet, et al.
Publicado: (2022)

Target genes of N6-methyladenosine regulatory protein ALKBH5 are associated with prognosis of patients with lung adenocarcinoma
por: Jiang, Long, et al.
Publicado: (2023)

ALKBH5 Stabilized N(6)-Methyladenosine—Modified LOC4191 to Suppress E. coli-Induced Apoptosis
por: Xu, Haojun, et al.
Publicado: (2023)

RNA m(6)A demethylase ALKBH5 regulates the development of γδ T cells
por: Ding, Chenbo, et al.
Publicado: (2022)

RNA demethylase ALKBH5 in cancer: from mechanisms to therapeutic potential
por: Qu, Jianwei, et al.
Publicado: (2022)

The emerging roles of N(6)-methyladenosine in osteoarthritis
por: Liu, Hui, et al.
Publicado: (2022)

AlkB RNA demethylase homologues and N (6) ‐methyladenosine are involved in Potyvirus infection
por: Yue, Jianying, et al.
Publicado: (2022)

Emerging Roles of N6-Methyladenosine Demethylases and Its Interaction with Environmental Toxicants in Digestive System Cancers
por: Liu, Caiping, et al.
Publicado: (2021)

Identification and Characterization of a Glucometabolic Prognostic Gene Signature in Neuroblastoma based on N6-methyladenosine Eraser ALKBH5
por: Tan, Kezhe, et al.
Publicado: (2022)

m(6)A demethylase ALKBH5 drives denervation‐induced muscle atrophy by targeting HDAC4 to activate FoxO3 signalling
por: Liu, Yuantong, et al.
Publicado: (2022)

Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase
por: Xia, Zhen, et al.
Publicado: (2021)

ALKBH5-mediated N(6)-methyladenosine modification of TRERNA1 promotes DLBCL proliferation via p21 downregulation
por: Song, Wei, et al.
Publicado: (2022)

m(6)A demethylase ALKBH5 is required for antibacterial innate defense by intrinsic motivation of neutrophil migration
por: Liu, Yang, et al.
Publicado: (2022)

Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification
por: Hu, Yiyang, et al.
Publicado: (2022)

Functional Characterization of a Putative RNA Demethylase ALKBH6 in Arabidopsis Growth and Abiotic Stress Responses
por: Huong, Trinh Thi, et al.
Publicado: (2020)

m(6)A demethylase ALKBH5 suppression contributes to esophageal squamous cell carcinoma progression
por: Xiao, Dong, et al.
Publicado: (2021)

m(6)A demethylase ALKBH5 controls CD4(+) T cell pathogenicity and promotes autoimmunity
por: Zhou, Jing, et al.
Publicado: (2021)

N6-methyladenosine demethylase FTO suppressed prostate cancer progression by maintaining CLIC4 mRNA stability
por: Zou, Libin, et al.
Publicado: (2022)

Nitric oxide inhibits FTO demethylase activity to regulate N(6)-methyladenosine mRNA methylation
por: Kuschman, Hannah Petraitis, et al.
Publicado: (2023)

Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer
por: Li, Yue, et al.
Publicado: (2019)

Structure of human RNA N(6)-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation
por: Aik, WeiShen, et al.
Publicado: (2014)

Deregulation of N6-Methyladenosine RNA Modification and Its Erasers FTO/ALKBH5 among the Main Renal Cell Tumor Subtypes
por: Guimarães-Teixeira, Catarina, et al.
Publicado: (2021)

DNA demethylase ALKBH1 promotes adipogenic differentiation via regulation of HIF-1 signaling
por: Liu, Yuting, et al.
Publicado: (2021)

RNA N6-Methyladenosine Modifications and Its Roles in Alzheimer’s Disease
por: Zhang, Runjiao, et al.
Publicado: (2022)

The DEAD-Box RNA Helicase DDX3 Interacts with m(6)A RNA Demethylase ALKBH5
por: Shah, Abdullah, et al.
Publicado: (2017)

Rational Design of Novel Anticancer Small-Molecule RNA m6A Demethylase ALKBH5 Inhibitors
por: Selberg, Simona, et al.
Publicado: (2021)

The m6A RNA Demethylase ALKBH5 Promotes Radioresistance and Invasion Capability of Glioma Stem Cells
por: Kowalski-Chauvel, Aline, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_nlqk96skjuoqh53gfnr3gfs0rr