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Long-range DNA end resection supports homologous recombination by checkpoint activation rather than extensive homology generation

Homologous recombination (HR), the high-fidelity mechanism for double-strand break (DSB) repair, relies on DNA end resection by nucleolytic degradation of the 5′-terminated ends. However, the role of long-range resection mediated by Exo1 and/or Sgs1-Dna2 in HR is not fully understood. Here, we show...

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Detalles Bibliográficos
Autores principales:	Kimble, Michael T, Johnson, Matthew J, Nester, Mattie R, Symington, Lorraine S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400078/ https://www.ncbi.nlm.nih.gov/pubmed/37387287 http://dx.doi.org/10.7554/eLife.84322

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