Cargando…

Mucormycosis: A Case Series

Mucormycosis is a potentially life-threatening invasive fungal infection caused by diverse fungal organisms in the order Mucorales. Traditional risk factors of mucormycosis include poorly controlled diabetes, hematological malignancies such as leukemia and lymphoma, and post-transplant patients, wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Yong, Jo Yen, Chong, Kai Li, Gan, Wee Fu, Zaidan, Nor Zaila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400303/
https://www.ncbi.nlm.nih.gov/pubmed/37546065
http://dx.doi.org/10.7759/cureus.41375
_version_ 1785084414203527168
author Yong, Jo Yen
Chong, Kai Li
Gan, Wee Fu
Zaidan, Nor Zaila
author_facet Yong, Jo Yen
Chong, Kai Li
Gan, Wee Fu
Zaidan, Nor Zaila
author_sort Yong, Jo Yen
collection PubMed
description Mucormycosis is a potentially life-threatening invasive fungal infection caused by diverse fungal organisms in the order Mucorales. Traditional risk factors of mucormycosis include poorly controlled diabetes, hematological malignancies such as leukemia and lymphoma, and post-transplant patients, with rhino-orbito-cerebral and pulmonary mucormycosis as common manifestations. We report four cases of mucormycosis precipitated by classical as well as atypical risk factors, with common sites of infection such as pulmonary and rhino-orbital to rare manifestations such as peritoneal mucormycosis. Diagnoses were confirmed by either a histopathological sample or a positive culture. Only one patient had concomitant positive culture and histopathology results. Low culture positivity rate has delayed the diagnosis of two cases. First-line antifungal therapy was limited to amphotericin B deoxycholate in three cases due to financial cost, but all patients responded to the treatment. There were two mortalities, but both were unrelated to disease progression. All cases had source control done, except for the patient with pulmonary mucormycosis, due to poor lung reserve which refrained him from surgery. With emerging evidence of local therapies for endobronchial lesions, they potentially serve as an alternative for patients who are not suitable for operation. This case series also aims to contribute to the local epidemiology of mucormycosis, highlights the importance of early diagnosis, and draws attention from stakeholders to the challenges faced in managing this life-threatening infection. 
format Online
Article
Text
id pubmed-10400303
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-104003032023-08-04 Mucormycosis: A Case Series Yong, Jo Yen Chong, Kai Li Gan, Wee Fu Zaidan, Nor Zaila Cureus Infectious Disease Mucormycosis is a potentially life-threatening invasive fungal infection caused by diverse fungal organisms in the order Mucorales. Traditional risk factors of mucormycosis include poorly controlled diabetes, hematological malignancies such as leukemia and lymphoma, and post-transplant patients, with rhino-orbito-cerebral and pulmonary mucormycosis as common manifestations. We report four cases of mucormycosis precipitated by classical as well as atypical risk factors, with common sites of infection such as pulmonary and rhino-orbital to rare manifestations such as peritoneal mucormycosis. Diagnoses were confirmed by either a histopathological sample or a positive culture. Only one patient had concomitant positive culture and histopathology results. Low culture positivity rate has delayed the diagnosis of two cases. First-line antifungal therapy was limited to amphotericin B deoxycholate in three cases due to financial cost, but all patients responded to the treatment. There were two mortalities, but both were unrelated to disease progression. All cases had source control done, except for the patient with pulmonary mucormycosis, due to poor lung reserve which refrained him from surgery. With emerging evidence of local therapies for endobronchial lesions, they potentially serve as an alternative for patients who are not suitable for operation. This case series also aims to contribute to the local epidemiology of mucormycosis, highlights the importance of early diagnosis, and draws attention from stakeholders to the challenges faced in managing this life-threatening infection.  Cureus 2023-07-04 /pmc/articles/PMC10400303/ /pubmed/37546065 http://dx.doi.org/10.7759/cureus.41375 Text en Copyright © 2023, Yong et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Infectious Disease
Yong, Jo Yen
Chong, Kai Li
Gan, Wee Fu
Zaidan, Nor Zaila
Mucormycosis: A Case Series
title Mucormycosis: A Case Series
title_full Mucormycosis: A Case Series
title_fullStr Mucormycosis: A Case Series
title_full_unstemmed Mucormycosis: A Case Series
title_short Mucormycosis: A Case Series
title_sort mucormycosis: a case series
topic Infectious Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400303/
https://www.ncbi.nlm.nih.gov/pubmed/37546065
http://dx.doi.org/10.7759/cureus.41375
work_keys_str_mv AT yongjoyen mucormycosisacaseseries
AT chongkaili mucormycosisacaseseries
AT ganweefu mucormycosisacaseseries
AT zaidannorzaila mucormycosisacaseseries