Cargando…
Mucormycosis: A Case Series
Mucormycosis is a potentially life-threatening invasive fungal infection caused by diverse fungal organisms in the order Mucorales. Traditional risk factors of mucormycosis include poorly controlled diabetes, hematological malignancies such as leukemia and lymphoma, and post-transplant patients, wit...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400303/ https://www.ncbi.nlm.nih.gov/pubmed/37546065 http://dx.doi.org/10.7759/cureus.41375 |
_version_ | 1785084414203527168 |
---|---|
author | Yong, Jo Yen Chong, Kai Li Gan, Wee Fu Zaidan, Nor Zaila |
author_facet | Yong, Jo Yen Chong, Kai Li Gan, Wee Fu Zaidan, Nor Zaila |
author_sort | Yong, Jo Yen |
collection | PubMed |
description | Mucormycosis is a potentially life-threatening invasive fungal infection caused by diverse fungal organisms in the order Mucorales. Traditional risk factors of mucormycosis include poorly controlled diabetes, hematological malignancies such as leukemia and lymphoma, and post-transplant patients, with rhino-orbito-cerebral and pulmonary mucormycosis as common manifestations. We report four cases of mucormycosis precipitated by classical as well as atypical risk factors, with common sites of infection such as pulmonary and rhino-orbital to rare manifestations such as peritoneal mucormycosis. Diagnoses were confirmed by either a histopathological sample or a positive culture. Only one patient had concomitant positive culture and histopathology results. Low culture positivity rate has delayed the diagnosis of two cases. First-line antifungal therapy was limited to amphotericin B deoxycholate in three cases due to financial cost, but all patients responded to the treatment. There were two mortalities, but both were unrelated to disease progression. All cases had source control done, except for the patient with pulmonary mucormycosis, due to poor lung reserve which refrained him from surgery. With emerging evidence of local therapies for endobronchial lesions, they potentially serve as an alternative for patients who are not suitable for operation. This case series also aims to contribute to the local epidemiology of mucormycosis, highlights the importance of early diagnosis, and draws attention from stakeholders to the challenges faced in managing this life-threatening infection. |
format | Online Article Text |
id | pubmed-10400303 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-104003032023-08-04 Mucormycosis: A Case Series Yong, Jo Yen Chong, Kai Li Gan, Wee Fu Zaidan, Nor Zaila Cureus Infectious Disease Mucormycosis is a potentially life-threatening invasive fungal infection caused by diverse fungal organisms in the order Mucorales. Traditional risk factors of mucormycosis include poorly controlled diabetes, hematological malignancies such as leukemia and lymphoma, and post-transplant patients, with rhino-orbito-cerebral and pulmonary mucormycosis as common manifestations. We report four cases of mucormycosis precipitated by classical as well as atypical risk factors, with common sites of infection such as pulmonary and rhino-orbital to rare manifestations such as peritoneal mucormycosis. Diagnoses were confirmed by either a histopathological sample or a positive culture. Only one patient had concomitant positive culture and histopathology results. Low culture positivity rate has delayed the diagnosis of two cases. First-line antifungal therapy was limited to amphotericin B deoxycholate in three cases due to financial cost, but all patients responded to the treatment. There were two mortalities, but both were unrelated to disease progression. All cases had source control done, except for the patient with pulmonary mucormycosis, due to poor lung reserve which refrained him from surgery. With emerging evidence of local therapies for endobronchial lesions, they potentially serve as an alternative for patients who are not suitable for operation. This case series also aims to contribute to the local epidemiology of mucormycosis, highlights the importance of early diagnosis, and draws attention from stakeholders to the challenges faced in managing this life-threatening infection. Cureus 2023-07-04 /pmc/articles/PMC10400303/ /pubmed/37546065 http://dx.doi.org/10.7759/cureus.41375 Text en Copyright © 2023, Yong et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Infectious Disease Yong, Jo Yen Chong, Kai Li Gan, Wee Fu Zaidan, Nor Zaila Mucormycosis: A Case Series |
title | Mucormycosis: A Case Series |
title_full | Mucormycosis: A Case Series |
title_fullStr | Mucormycosis: A Case Series |
title_full_unstemmed | Mucormycosis: A Case Series |
title_short | Mucormycosis: A Case Series |
title_sort | mucormycosis: a case series |
topic | Infectious Disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400303/ https://www.ncbi.nlm.nih.gov/pubmed/37546065 http://dx.doi.org/10.7759/cureus.41375 |
work_keys_str_mv | AT yongjoyen mucormycosisacaseseries AT chongkaili mucormycosisacaseseries AT ganweefu mucormycosisacaseseries AT zaidannorzaila mucormycosisacaseseries |