Cargando…

Tricuspid regurgitation: a hidden risk factor for atrial fibrillation related stroke?

BACKGROUND AND PURPOSE: Tricuspid regurgitation (TR) is a common but overlooked valvular disease, and its association with the etiologic subtypes of ischemic stroke is unclear. We explored the relationship between TR and atrial fibrillation (AF) in patients with acute ischemic stroke. METHODS: This...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Yong Soo, Jeong, Han-Gil, Hwang, In-Chang, Kim, Beom Joon, Kwon, Joon-Myung, Bae, Hee-Joon, Han, Moon-Ku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400321/
https://www.ncbi.nlm.nih.gov/pubmed/37547251
http://dx.doi.org/10.3389/fcvm.2023.1135069
_version_ 1785084417903951872
author Kim, Yong Soo
Jeong, Han-Gil
Hwang, In-Chang
Kim, Beom Joon
Kwon, Joon-Myung
Bae, Hee-Joon
Han, Moon-Ku
author_facet Kim, Yong Soo
Jeong, Han-Gil
Hwang, In-Chang
Kim, Beom Joon
Kwon, Joon-Myung
Bae, Hee-Joon
Han, Moon-Ku
author_sort Kim, Yong Soo
collection PubMed
description BACKGROUND AND PURPOSE: Tricuspid regurgitation (TR) is a common but overlooked valvular disease, and its association with the etiologic subtypes of ischemic stroke is unclear. We explored the relationship between TR and atrial fibrillation (AF) in patients with acute ischemic stroke. METHODS: This retrospective analysis of ongoing stroke registry assessed 6,886 consecutive acute ischemic stroke patients who underwent transthoracic echocardiography during their in-hospital care. Multivariable logistic regression models adjusted for age, sex, stroke characteristics, and echocardiographic indices were used to investigate the association between TR and total AF, and newly diagnosed AF during hospitalization and a 1-year follow-up period, respectively. RESULTS: TR was present in 877 (12.7%) patients (mild, 9.9%; moderate, 2.4%; severe, 0.5%). AF was identified in 24.1% (medical history, 11.1%; first detected in the emergency room, 6.6%; newly diagnosed after admission, 6.4%). TR was associated with AF [adjusted odds ratio (aOR) 4.87 (95% confidence interval (CI), 2.63–9.03)], compared with no/trivial TR. The association between TR and AF was consistent regardless of severity (aOR [95% CI], 4.57 [2.63–7.94] for mild and 7.05 [2.57–19.31] for moderate-to-severe TR) or subtype of TR (5.44 [2.91–10.14] for isolated and 3.81 [2.00–7.28] for non-isolated TR). Among the AF-naïve patients at admission, TR was associated with newly diagnosed AF during hospitalization and a 1-year follow-up period (aOR [95% CI], 2.68 [1.81–3.97]). CONCLUSIONS: TR is associated with AF in acute ischemic stroke patients regardless of severity and subtypes of TR. TR is also associated with newly diagnosed AF after stroke.
format Online
Article
Text
id pubmed-10400321
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-104003212023-08-04 Tricuspid regurgitation: a hidden risk factor for atrial fibrillation related stroke? Kim, Yong Soo Jeong, Han-Gil Hwang, In-Chang Kim, Beom Joon Kwon, Joon-Myung Bae, Hee-Joon Han, Moon-Ku Front Cardiovasc Med Cardiovascular Medicine BACKGROUND AND PURPOSE: Tricuspid regurgitation (TR) is a common but overlooked valvular disease, and its association with the etiologic subtypes of ischemic stroke is unclear. We explored the relationship between TR and atrial fibrillation (AF) in patients with acute ischemic stroke. METHODS: This retrospective analysis of ongoing stroke registry assessed 6,886 consecutive acute ischemic stroke patients who underwent transthoracic echocardiography during their in-hospital care. Multivariable logistic regression models adjusted for age, sex, stroke characteristics, and echocardiographic indices were used to investigate the association between TR and total AF, and newly diagnosed AF during hospitalization and a 1-year follow-up period, respectively. RESULTS: TR was present in 877 (12.7%) patients (mild, 9.9%; moderate, 2.4%; severe, 0.5%). AF was identified in 24.1% (medical history, 11.1%; first detected in the emergency room, 6.6%; newly diagnosed after admission, 6.4%). TR was associated with AF [adjusted odds ratio (aOR) 4.87 (95% confidence interval (CI), 2.63–9.03)], compared with no/trivial TR. The association between TR and AF was consistent regardless of severity (aOR [95% CI], 4.57 [2.63–7.94] for mild and 7.05 [2.57–19.31] for moderate-to-severe TR) or subtype of TR (5.44 [2.91–10.14] for isolated and 3.81 [2.00–7.28] for non-isolated TR). Among the AF-naïve patients at admission, TR was associated with newly diagnosed AF during hospitalization and a 1-year follow-up period (aOR [95% CI], 2.68 [1.81–3.97]). CONCLUSIONS: TR is associated with AF in acute ischemic stroke patients regardless of severity and subtypes of TR. TR is also associated with newly diagnosed AF after stroke. Frontiers Media S.A. 2023-07-18 /pmc/articles/PMC10400321/ /pubmed/37547251 http://dx.doi.org/10.3389/fcvm.2023.1135069 Text en © 2023 Kim, Jeong, Hwang, Kim, Kwon, Bae and Han. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Kim, Yong Soo
Jeong, Han-Gil
Hwang, In-Chang
Kim, Beom Joon
Kwon, Joon-Myung
Bae, Hee-Joon
Han, Moon-Ku
Tricuspid regurgitation: a hidden risk factor for atrial fibrillation related stroke?
title Tricuspid regurgitation: a hidden risk factor for atrial fibrillation related stroke?
title_full Tricuspid regurgitation: a hidden risk factor for atrial fibrillation related stroke?
title_fullStr Tricuspid regurgitation: a hidden risk factor for atrial fibrillation related stroke?
title_full_unstemmed Tricuspid regurgitation: a hidden risk factor for atrial fibrillation related stroke?
title_short Tricuspid regurgitation: a hidden risk factor for atrial fibrillation related stroke?
title_sort tricuspid regurgitation: a hidden risk factor for atrial fibrillation related stroke?
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400321/
https://www.ncbi.nlm.nih.gov/pubmed/37547251
http://dx.doi.org/10.3389/fcvm.2023.1135069
work_keys_str_mv AT kimyongsoo tricuspidregurgitationahiddenriskfactorforatrialfibrillationrelatedstroke
AT jeonghangil tricuspidregurgitationahiddenriskfactorforatrialfibrillationrelatedstroke
AT hwanginchang tricuspidregurgitationahiddenriskfactorforatrialfibrillationrelatedstroke
AT kimbeomjoon tricuspidregurgitationahiddenriskfactorforatrialfibrillationrelatedstroke
AT kwonjoonmyung tricuspidregurgitationahiddenriskfactorforatrialfibrillationrelatedstroke
AT baeheejoon tricuspidregurgitationahiddenriskfactorforatrialfibrillationrelatedstroke
AT hanmoonku tricuspidregurgitationahiddenriskfactorforatrialfibrillationrelatedstroke