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Helicobacter pylori-negative Gastric Adenocarcinoma Mimicking Verrucous Gastritis in the Antrum: A Case Report and Literature Review

A 46-year-old man was referred to our hospital for the examination of a flat elevated lesion with an erosion-like depression, located on the greater curvature of the antrum. Endoscopic submucosal dissection was performed. Histological findings of the resected specimen demonstrated a well-differentia...

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Autores principales: Murawaki, Yoshiyuki, Yashima, Kazuo, Horie, Satoshi, Miura, Masahiko, Kato, Jun, Hirai, Takayuki, Takeda, Kazuki, Kono, Michimori, Yoshida, Manabu, Isomoto, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400381/
https://www.ncbi.nlm.nih.gov/pubmed/36450460
http://dx.doi.org/10.2169/internalmedicine.0246-22
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author Murawaki, Yoshiyuki
Yashima, Kazuo
Horie, Satoshi
Miura, Masahiko
Kato, Jun
Hirai, Takayuki
Takeda, Kazuki
Kono, Michimori
Yoshida, Manabu
Isomoto, Hajime
author_facet Murawaki, Yoshiyuki
Yashima, Kazuo
Horie, Satoshi
Miura, Masahiko
Kato, Jun
Hirai, Takayuki
Takeda, Kazuki
Kono, Michimori
Yoshida, Manabu
Isomoto, Hajime
author_sort Murawaki, Yoshiyuki
collection PubMed
description A 46-year-old man was referred to our hospital for the examination of a flat elevated lesion with an erosion-like depression, located on the greater curvature of the antrum. Endoscopic submucosal dissection was performed. Histological findings of the resected specimen demonstrated a well-differentiated tubular adenocarcinoma with a diameter of 12 mm. No atrophy was observed in the tumor-adjacent mucosa. Serum Helicobacter pylori antibody estimation and (13)C-urea breath tests yielded negative results. Immunohistochemical staining was positive for both gastric mucin and intestinal mucin. The final diagnosis was well-differentiated tubular adenocarcinoma with a gastrointestinal phenotype that originated in mucosa uninfected by H. pylori.
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spelling pubmed-104003812023-08-05 Helicobacter pylori-negative Gastric Adenocarcinoma Mimicking Verrucous Gastritis in the Antrum: A Case Report and Literature Review Murawaki, Yoshiyuki Yashima, Kazuo Horie, Satoshi Miura, Masahiko Kato, Jun Hirai, Takayuki Takeda, Kazuki Kono, Michimori Yoshida, Manabu Isomoto, Hajime Intern Med Case Report A 46-year-old man was referred to our hospital for the examination of a flat elevated lesion with an erosion-like depression, located on the greater curvature of the antrum. Endoscopic submucosal dissection was performed. Histological findings of the resected specimen demonstrated a well-differentiated tubular adenocarcinoma with a diameter of 12 mm. No atrophy was observed in the tumor-adjacent mucosa. Serum Helicobacter pylori antibody estimation and (13)C-urea breath tests yielded negative results. Immunohistochemical staining was positive for both gastric mucin and intestinal mucin. The final diagnosis was well-differentiated tubular adenocarcinoma with a gastrointestinal phenotype that originated in mucosa uninfected by H. pylori. The Japanese Society of Internal Medicine 2022-11-30 2023-07-15 /pmc/articles/PMC10400381/ /pubmed/36450460 http://dx.doi.org/10.2169/internalmedicine.0246-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Murawaki, Yoshiyuki
Yashima, Kazuo
Horie, Satoshi
Miura, Masahiko
Kato, Jun
Hirai, Takayuki
Takeda, Kazuki
Kono, Michimori
Yoshida, Manabu
Isomoto, Hajime
Helicobacter pylori-negative Gastric Adenocarcinoma Mimicking Verrucous Gastritis in the Antrum: A Case Report and Literature Review
title Helicobacter pylori-negative Gastric Adenocarcinoma Mimicking Verrucous Gastritis in the Antrum: A Case Report and Literature Review
title_full Helicobacter pylori-negative Gastric Adenocarcinoma Mimicking Verrucous Gastritis in the Antrum: A Case Report and Literature Review
title_fullStr Helicobacter pylori-negative Gastric Adenocarcinoma Mimicking Verrucous Gastritis in the Antrum: A Case Report and Literature Review
title_full_unstemmed Helicobacter pylori-negative Gastric Adenocarcinoma Mimicking Verrucous Gastritis in the Antrum: A Case Report and Literature Review
title_short Helicobacter pylori-negative Gastric Adenocarcinoma Mimicking Verrucous Gastritis in the Antrum: A Case Report and Literature Review
title_sort helicobacter pylori-negative gastric adenocarcinoma mimicking verrucous gastritis in the antrum: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400381/
https://www.ncbi.nlm.nih.gov/pubmed/36450460
http://dx.doi.org/10.2169/internalmedicine.0246-22
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