A Patient with Severe Fever with Thrombocytopenia Syndrome, Activated Partial Thromboplastin Time Prolongation, and Transient Antiphospholipid Antibodies

A prolonged activated partial thromboplastin time (APTT) is observed in patients with severe fever with thrombocytopenia syndrome (SFTS) and is one of the risk factors for severe disease. The mechanism underlying a prolonged APTT is largely unknown. The presence of antiphospholipid (aPL) antibodies...

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Autores principales: Tsukamoto, Yutaka, Sugimoto, Takashi, Umeda, Masataka, Kato, Takeharu, Hiura, Yukari, Morita, Kouichi, Ariyoshi, Koya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400393/
https://www.ncbi.nlm.nih.gov/pubmed/36476549
http://dx.doi.org/10.2169/internalmedicine.0782-22
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author Tsukamoto, Yutaka
Sugimoto, Takashi
Umeda, Masataka
Kato, Takeharu
Hiura, Yukari
Morita, Kouichi
Ariyoshi, Koya
author_facet Tsukamoto, Yutaka
Sugimoto, Takashi
Umeda, Masataka
Kato, Takeharu
Hiura, Yukari
Morita, Kouichi
Ariyoshi, Koya
author_sort Tsukamoto, Yutaka
collection PubMed
description A prolonged activated partial thromboplastin time (APTT) is observed in patients with severe fever with thrombocytopenia syndrome (SFTS) and is one of the risk factors for severe disease. The mechanism underlying a prolonged APTT is largely unknown. The presence of antiphospholipid (aPL) antibodies in various viral infections has been documented but never reported in a patient with SFTS. We herein report the first SFTS patient with APTT prolongation and concurrent transiently positive aPL antibodies (lupus anticoagulants and anticardiolipin antibodies) with no coagulation factor deficiency.
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spelling pubmed-104003932023-08-05 A Patient with Severe Fever with Thrombocytopenia Syndrome, Activated Partial Thromboplastin Time Prolongation, and Transient Antiphospholipid Antibodies Tsukamoto, Yutaka Sugimoto, Takashi Umeda, Masataka Kato, Takeharu Hiura, Yukari Morita, Kouichi Ariyoshi, Koya Intern Med Case Report A prolonged activated partial thromboplastin time (APTT) is observed in patients with severe fever with thrombocytopenia syndrome (SFTS) and is one of the risk factors for severe disease. The mechanism underlying a prolonged APTT is largely unknown. The presence of antiphospholipid (aPL) antibodies in various viral infections has been documented but never reported in a patient with SFTS. We herein report the first SFTS patient with APTT prolongation and concurrent transiently positive aPL antibodies (lupus anticoagulants and anticardiolipin antibodies) with no coagulation factor deficiency. The Japanese Society of Internal Medicine 2022-12-07 2023-07-15 /pmc/articles/PMC10400393/ /pubmed/36476549 http://dx.doi.org/10.2169/internalmedicine.0782-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Tsukamoto, Yutaka
Sugimoto, Takashi
Umeda, Masataka
Kato, Takeharu
Hiura, Yukari
Morita, Kouichi
Ariyoshi, Koya
A Patient with Severe Fever with Thrombocytopenia Syndrome, Activated Partial Thromboplastin Time Prolongation, and Transient Antiphospholipid Antibodies
title A Patient with Severe Fever with Thrombocytopenia Syndrome, Activated Partial Thromboplastin Time Prolongation, and Transient Antiphospholipid Antibodies
title_full A Patient with Severe Fever with Thrombocytopenia Syndrome, Activated Partial Thromboplastin Time Prolongation, and Transient Antiphospholipid Antibodies
title_fullStr A Patient with Severe Fever with Thrombocytopenia Syndrome, Activated Partial Thromboplastin Time Prolongation, and Transient Antiphospholipid Antibodies
title_full_unstemmed A Patient with Severe Fever with Thrombocytopenia Syndrome, Activated Partial Thromboplastin Time Prolongation, and Transient Antiphospholipid Antibodies
title_short A Patient with Severe Fever with Thrombocytopenia Syndrome, Activated Partial Thromboplastin Time Prolongation, and Transient Antiphospholipid Antibodies
title_sort patient with severe fever with thrombocytopenia syndrome, activated partial thromboplastin time prolongation, and transient antiphospholipid antibodies
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400393/
https://www.ncbi.nlm.nih.gov/pubmed/36476549
http://dx.doi.org/10.2169/internalmedicine.0782-22
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