Resolution of Laryngeal Ulceration with Prednisolone Therapy in a Patient with Crohn's Disease

A 23-year-old man diagnosed with Crohn's disease (CD) was treated with infliximab. He developed new-onset sore throat and dysphagia during admission, and nasopharyngoscopy revealed epiglottic ulceration. Laryngeal ulceration was considered as an extraintestinal manifestation of CD owing to trea...

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Detalles Bibliográficos
Autores principales: Ko, Yi-Ling, Matsuoka, Hiroki, Nomaru, Ryohei, Imakiire, So, Sakisaka, Hideto, Matsuoka, Satoshi, Kuno, Nobuaki, Abe, Koichi, Funakoshi, Sadahiro, Ishida, Yusuke, Ishibashi, Hideki, Miyagi, Shinpei, Sakata, Toshifumi, Hirai, Fumihito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400401/
https://www.ncbi.nlm.nih.gov/pubmed/36450464
http://dx.doi.org/10.2169/internalmedicine.0422-22
Descripción
Sumario:A 23-year-old man diagnosed with Crohn's disease (CD) was treated with infliximab. He developed new-onset sore throat and dysphagia during admission, and nasopharyngoscopy revealed epiglottic ulceration. Laryngeal ulceration was considered as an extraintestinal manifestation of CD owing to treatment failure with antibiotics and hydrocortisone. This strongly suggested that laryngeal ulceration was a complication of CD because of the rapid improvement in the symptoms and lesions after prednisolone administration. Furthermore, this treatment process demonstrated the superior anti-inflammatory effect of prednisolone over that of hydrocortisone and supported the assumption of inflammation related to CD.

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